| General information | | DisProt: | DP00608 | | Name: | SNW domain-containing protein 1 | | Synonym(s): | SNW1_HUMAN
Nuclear protein SkiP
Ski-interacting protein
Nuclear receptor coactivator NCoA-62
SKIP
| | First appeared in release: | Release 5.1 (05/28/2010) | | UniProt: | Q13573 | | UniGene: | Hs.445498 | | SwissProt: | SNW1_HUMAN | | TrEMBL: | | | NCBI (GI): | 2500813 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 536 | | Percent disordered: | 13% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MALTSFLPAP TQLSQDQLEA EEKARSQRSR QTSLVSSRRE PPPYGYRKGW IPRLLEDFGD - 60
GGAFPEIHVA QYPLDMGRKK KMSNALAIQV DSEGKIKYDA IARQGQSKDK VIYSKYTDLV - 120
PKEVMNADDP DLQRPDEEAI KEITEKTRVA LEKSVSQKVA AAMPVRAADK LAPAQYIRYT - 180
PSQQGVAFNS GAKQRVIRMV EMQKDPMEPP RFKINKKIPR GPPSPPAPVM HSPSRKMTVK - 240
EQQEWKIPPC ISNWKNAKGY TIPLDKRLAA DGRGLQTVHI NENFAKLAEA LYIADRKARE - 300
AVEMRAQVER KMAQKEKEKH EEKLREMAQK ARERRAGIKT HVEKEDGEAR ERDEIRHDRR - 360
KERQHDRNLS RAAPDKRSKL QRNENRDISE VIALGVPNPR TSNEVQYDQR LFNQSKGMDS - 420
GFAGGEDEIY NVYDQAWRGG KDMAQSIYRP SKNLDKDMYG DDLEARIKTN RFVPDKEFSG - 480
SDRRQRGREG PVQFEEDPFG LDKFLEEAKQ HGGSKRPSDS SRPKEHEHEG KKRRKE
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| Functional narrative |
Involved in vitamin D-mediated transcription. Can function as a splicing factor in pre-mRNA splicing
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | SKIPN | | Location: | 59 - 129 | | Length: | 71 | | Region sequence: |
GDGGAFPEIHVAQYPLDMGRKKKMSNALAIQVDSEGKIKYDAIARQGQSKDKVIYSKYTD
LVPKEVMNADD | | Modification type: | Monomeric
| | PDB: | | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Molecular recognition effectors
| | Functional subclasses: | Phosphorylation
| Detection methods:
| References:
- Wang X, Zhang S, Zhang J, Huang X, Xu C, Wang W, Liu Z, Wu J, Shi Y. "A large intrinsically disordered region in SKIP and its disorder-order transition induced by PPIL1 binding revealed by NMR." J Biol Chem. 2009. PubMed: 20007319
| Comments:
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| References |
- Wang X, Zhang S, Zhang J, Huang X, Xu C, Wang W, Liu Z, Wu J, Shi Y. "A large intrinsically disordered region in SKIP and its disorder-order transition induced by PPIL1 binding revealed by NMR." J Biol Chem. 2009. PubMed: 20007319
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