Disprot - Database of Protein Disorder

DP00617: 26S proteasome complex subunit DSS1

General information
DisProt:	DP00617
Name:	26S proteasome complex subunit DSS1
Synonym(s):	DSS1_HUMAN DSS1 Deleted in split hand/split foot protein 1 Split hand/foot malformation type 1 protein Split hand/foot deleted protein 1 Brh2-interacting protein Dss1
First appeared in release:	Release 5.3 (09/21/2010)
UniProt:	P60896
UniGene:
SwissProt:	DSS1_HUMAN
TrEMBL:
NCBI (GI):
Source organism:	Homo Sapiens (Human)
Sequence length:	70
Percent disordered:	100%
Homologues:

Native sequence

10 20 30 40 50 60
| | | | | |
MSEKKQPVDL GLLEEDDEFE EFPAEDWAGL DEDEDAHVWE DNWDDDNVED DFSNQLRAEL - 60
EKHGYKMETS

Functional narrative

Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis. Interacts with the C-terminal of BRCA2.

Map of ordered and disordered regions
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.

Region 1
Type:	Disordered - Extended
Name:	N-terminal domain
Location:	1 - 25
Length:	25
Region sequence:	MSEKKQPVDLGLLEEDDEFEEFPAE
Modification type:	Complex Native
PDB:	1MIU:B, 1IYJ:A, 1MJE:B
Structural/functional type:	Function arises from the disordered state
Functional classes:	Chaperones
Functional subclasses:	Protein-protein binding
Detection methods: X-ray crystallography (277 K; pH: 8; CaCL2; DTT; NaCl; PEG 4000; Tris-HCl)
References: There are no documents referencing this region.
Comments: Region 1 contains a BRCA2 binding site (aa 7-25); these residues are highly conserved (Yang 2002) Main reference: Yang H et al (2002) PMID 12228710. The PDB structures from Yang et al. (2002) show DSS1 in complex with BRCA2 (1IJY and 1MIU), and a complex of DSS1-BRCA2-ssDNA (1MJE).

Region 2
Type:	Disordered - Extended
Name:
Location:	26 - 36
Length:	11
Region sequence:	DWAGLDEDEDA
Modification type:	Complex Native
PDB:	1IYJ:A, 1MIU:B, 1MJE:B
Structural/functional type:	Relationship to function unknown
Functional classes:	Unknown
Functional subclasses:	Unknown
Detection methods: X-ray crystallography (277 K; pH: 8; CaCL2; DTT; NaCl; PEG 4000; Tris-HCl)
References: There are no documents referencing this region.
Comments: Main reference: Yang H et al (2002) PMID 12228710. The PDB structures from Yang et al. (2002) show DSS1 in complex with BRCA2 (1IJY and 1MIU), and a complex of DSS1-BRCA2-ssDNA (1MJE).

Region 3
Type:	Disordered - Extended
Name:	C-terminal domain
Location:	37 - 70
Length:	34
Region sequence:	HVWEDNWDDDNVEDDFSNQLRAELEKHGYKMETS
Modification type:	Complex Native
PDB:	1IYJ:A, 1MIU:B, 1MJE:B
Structural/functional type:	Function arises from the disordered state
Functional classes:	Chaperones
Functional subclasses:	Protein-protein binding
Detection methods: X-ray crystallography (277 K; pH: 8; CaCL2; DTT; NaCl; PEG 4000; Tris-HCl)
References: There are no documents referencing this region.
Comments: Main reference: Yang H et al (2002) PMID 12228710. The PDB structures from Yang et al. (2002) show DSS1 in complex with BRCA2 (1IJY and 1MIU), and a complex of DSS1-BRCA2-ssDNA (1MJE). Region 3 contains a BRCA2 binding site (aa 37-63); these residues are highly conserved (Yang 2002)

Comments
Main reference: Yang H et al (2002) PMID 12228710. The PDB structures from Yang et al. (2002) show DSS1 in complex with BRCA2 (1IJY and 1MIU), and a complex of DSS1-BRCA2-ssDNA (1MJE). Sent for AV 9-15-2010 (PMID 12228710)