DP00620: Selenocysteine lyaseFASTA viewXML view

General information
DisProt:DP00620
Name:Selenocysteine lyase
Synonym(s):SCLY_RAT
First appeared in release:Release 5.1 (05/28/2010)
UniProt:Q68FT9
UniGene:Rn.23954
SwissProt: SCLY_RAT
TrEMBL:  
NCBI (GI): 56090261
Source organism:Rattus norvegicus (Rat)
Sequence length:432
Percent disordered:4%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MDVARNGARG SVESPPNRKV YMDYNATTPL EPEVIQAVTE AMKEAWGNPS SSYVAGRKAK - 60
DIINTARASL AKMIGGKPQD IIFTSGGTES NNLVIHSTVR CFHEQQTLQG RTVDQISPEE - 120
GTRPHFITCT VEHDSIRLPL EHLVEDQVAE VTFVPVSKVN GQVEVEDILA AVRPTTCLVT - 180
IMLANNETGV IMPISEISRR IKALNQIRAA SGLPRVLVHT DAAQALGKRR VDVEDLGVDF - 240
LTIVGHKFYG PRIGALYVRG VGKLTPLYPM LFGGGQERNF RPGTENTPMI AGLGKAADLV - 300
SENCETYEAH MRDIRDYLEE RLEAEFGKRI HLNSRFPGVE RLPNTCNFSI QGSQLRGYMV - 360
LAQCQTLLAS VGASCHSDHE DRPSPVLLSC GIPVDVARNA VRLSVGRSTT RAEVDLIVQD - 420
LKQAVNQLEG PV



Functional narrative    

Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

Region 1: 374-392

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name:extended lobe
Location:374 - 392
Length:19
Region sequence:

SCHSDHEDRPSPVLLSCGI

Modification type: Native
PDB: 2HDY:A, 2HDY:B, 3GZC:A, 3GZC:B
Structural/functional type: Function arises via a disorder to order transition
Functional classes:  
Functional subclasses: Substrate/ligand binding
Detection methods:
  1. X-ray crystallography (100 K; pH: 8; resolution 2 A; wavelength 1 A)

References:
  1. Omi R, Kurokawa S, Mihara H, Hayashi H, Goto M, Miyahara I, Kurihara T, Hirotsu K, Esaki N. "Reaction mechanism and molecular basis for selenium/sulfur discrimination of selenocysteine lyase." J Biol Chem. 2010; 285(16): 12133-12139. PubMed: 20164179

Comments:
PDB ID 3GZC is the current version in PDB. The previous version, 2HDY is noted in the reference paper linked to this disordered region.



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