General information | DisProt: | DP00620 | Name: | Selenocysteine lyase | Synonym(s): | SCLY_RAT
| First appeared in release: | Release 5.1 (05/28/2010) | UniProt: | Q68FT9 | UniGene: | Rn.23954 | SwissProt: | SCLY_RAT | TrEMBL: | | NCBI (GI): | 56090261 | Source organism: | Rattus norvegicus (Rat) | Sequence length: | 432 | Percent disordered: | 4% | Homologues: | |
Native sequence |
10 20 30 40 50 60 | | | | | | MDVARNGARG SVESPPNRKV YMDYNATTPL EPEVIQAVTE AMKEAWGNPS SSYVAGRKAK - 60 DIINTARASL AKMIGGKPQD IIFTSGGTES NNLVIHSTVR CFHEQQTLQG RTVDQISPEE - 120 GTRPHFITCT VEHDSIRLPL EHLVEDQVAE VTFVPVSKVN GQVEVEDILA AVRPTTCLVT - 180 IMLANNETGV IMPISEISRR IKALNQIRAA SGLPRVLVHT DAAQALGKRR VDVEDLGVDF - 240 LTIVGHKFYG PRIGALYVRG VGKLTPLYPM LFGGGQERNF RPGTENTPMI AGLGKAADLV - 300 SENCETYEAH MRDIRDYLEE RLEAEFGKRI HLNSRFPGVE RLPNTCNFSI QGSQLRGYMV - 360 LAQCQTLLAS VGASCHSDHE DRPSPVLLSC GIPVDVARNA VRLSVGRSTT RAEVDLIVQD - 420 LKQAVNQLEG PV
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Functional narrative |
Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium.
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
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Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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Region 1 | Type: | Disordered | Name: | extended lobe | Location: | 374 - 392 | Length: | 19 | Region sequence: |
SCHSDHEDRPSPVLLSCGI | Modification type: | Native
| PDB: | 2HDY:A, 2HDY:B, 3GZC:A, 3GZC:B | Structural/functional type: | Function arises via a disorder to order transition | Functional classes: | | Functional subclasses: | Substrate/ligand binding
| Detection methods:
- X-ray crystallography (100 K; pH: 8; resolution 2 A; wavelength 1 A)
| References:
- Omi R, Kurokawa S, Mihara H, Hayashi H, Goto M, Miyahara I, Kurihara T, Hirotsu K, Esaki N. "Reaction mechanism and molecular basis for selenium/sulfur discrimination of selenocysteine lyase." J Biol Chem. 2010; 285(16): 12133-12139. PubMed: 20164179
| Comments:PDB ID 3GZC is the current version in PDB. The previous version, 2HDY is noted in the reference paper linked to this disordered region.
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