| General information | | DisProt: | DP00627 | | Name: | Minor nucleoprotein VP30 | | Synonym(s): | VP30_EBOZM
Transcription activator VP30
| | First appeared in release: | Release 5.2 (08/07/2010) | | UniProt: | Q05323 | | UniGene: | | | SwissProt: | VP30_EBOZM | | TrEMBL: | | | NCBI (GI): | 8489008 | | Source organism: | Zaire ebolavirus (strain Mayinga-76)(ZEBOV)(Zaire Ebola virus) | | Sequence length: | 288 | | Percent disordered: | 5% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MEASYERGRP RAARQHSRDG HDHHVRARSS SRENYRGEYR QSRSASQVRV PTVFHKKRVE - 60
PLTVPPAPKD ICPTLKKGFL CDSSFCKKDH QLESLTDREL LLLIARKTCG SVEQQLNITA - 120
PKDSRLANPT ADDFQQEEGP KITLLTLIKT AEHWARQDIR TIEDSKLRAL LTLCAVMTRK - 180
FSKSQLSLLC ETHLRREGLG QDQAEPVLEV YQRLHSDKGG SFEAALWQQW DRQSLIMFIT - 240
AFLNIALQLP CESSAVVVSG LRTLVPQSDN EEASTNPGTC SWSDEGTP
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| Functional narrative |
Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of a RNA stem-loop at the transcription start site of the first gene. Binds to RNA.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 27 - 40 | | Length: | 14 | | Region sequence: |
ARSSSRENYRGEYR | | Modification type: | Fragment
| | PDB: | | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | Transactivation (transcriptional activation)
| Detection methods:
- Immunochemistry
| References:
- John SP, Wang T, Steffen S, Longhi S, Schmaljohn CS, Jonsson CB. "Ebola virus VP30 is an RNA binding protein." J Virol. 2007; 81(17): 8967-76. PubMed: 17567691
| Comments:Increased RNA affinity at low pH.
Binding ability is strongly dependent upon presence of Zn2+.
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| References |
- John SP, Wang T, Steffen S, Longhi S, Schmaljohn CS, Jonsson CB. "Ebola virus VP30 is an RNA binding protein." J Virol. 2007; 81(17): 8967-76. PubMed: 17567691
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| Comments |
AV (7-27-2010) PubMed: 17567691
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