General information | DisProt: | DP00630 | Name: | Gamma-synuclein | Synonym(s): | SYUG_HUMAN
Persyn
Breast cancer-specific gene 1 protein
Synoretin
SR
Synuclein-gamma
SNCG
| First appeared in release: | Release 5.2 (08/07/2010) | UniProt: | O76070 | UniGene: | Hs.349470 | SwissProt: | SYUG_HUMAN | TrEMBL: | | NCBI (GI): | 90110074 | Source organism: | Homo sapiens (Human) | Sequence length: | 127 | Percent disordered: | 100% | Homologues: | |
Native sequence |
10 20 30 40 50 60 | | | | | | MDVFKKGFSI AKEGVVGAVE KTKQGVTEAA EKTKEGVMYV GAKTKENVVQ SVTSVAEKTK - 60 EQANAVSEAV VSSVNTVATK TVEEAENIAV TSGVVRKEDL RPSAPQQEGE ASKEKEEVAE - 120 EAQSGGD
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Functional narrative |
Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway.
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Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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Region 1 | Type: | Disordered | Name: | | Location: | 1 - 127 | Length: | 127 | Region sequence: |
MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKENVVQSVTSVAEKTK EQANAVSEAVVSSVNTVATKTVEEAENIAVTSGVVRKEDLRPSAPQQEGEASKEKEEVAE EAQSGGD | Modification type: | Engineered
| PDB: | | Structural/functional type: | Function arises from the disordered state | Functional classes: | Molecular recognition effectors
| Functional subclasses: | Protein-protein binding
| Detection methods:
- Nuclear magnetic resonance (NMR) (278 K; pH: 7; D2O 7.5 %; SNCG (15N-labelled) 0.35 mM/L; sodium phosphate (buffer) 10 mM/L)
- Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 7; ANK peptide (binding partner); SNCG 0.145 mg/mL; sodium phosphate (buffer) 5 mM/L)
| References:
- Singh VK, Zhou Y, Marsh JA, Uversky VN, Forman-Kay JD, Liu J, Jia Z. "Synuclein-gamma targeting peptide inhibitor that enhances sensitivity of breast cancer cells to antimicrotubule drugs." Cancer Res. 2007; 67(2): 626-33. PubMed: 17234772
| Comments:
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References |
- Singh VK, Zhou Y, Marsh JA, Uversky VN, Forman-Kay JD, Liu J, Jia Z. "Synuclein-gamma targeting peptide inhibitor that enhances sensitivity of breast cancer cells to antimicrotubule drugs." Cancer Res. 2007; 67(2): 626-33. PubMed: 17234772
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Comments |
AV (7-27-2010) PubMed: 17234772
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