DP00630: Gamma-synucleinFASTA viewXML view

General information
DisProt:DP00630
Name:Gamma-synuclein
Synonym(s):SYUG_HUMAN
Persyn
Breast cancer-specific gene 1 protein
Synoretin
SR
Synuclein-gamma
SNCG
First appeared in release:Release 5.2 (08/07/2010)
UniProt:O76070
UniGene:Hs.349470
SwissProt: SYUG_HUMAN
TrEMBL:  
NCBI (GI): 90110074
Source organism:Homo sapiens (Human)
Sequence length:127
Percent disordered:100%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MDVFKKGFSI AKEGVVGAVE KTKQGVTEAA EKTKEGVMYV GAKTKENVVQ SVTSVAEKTK - 60
EQANAVSEAV VSSVNTVATK TVEEAENIAV TSGVVRKEDL RPSAPQQEGE ASKEKEEVAE - 120
EAQSGGD



Functional narrative    

Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway.

Region 1: 1-127

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:1 - 127
Length:127
Region sequence:

MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKENVVQSVTSVAEKTK
EQANAVSEAVVSSVNTVATKTVEEAENIAVTSGVVRKEDLRPSAPQQEGEASKEKEEVAE
EAQSGGD

Modification type: Engineered
PDB:  
Structural/functional type: Function arises from the disordered state
Functional classes: Molecular recognition effectors
Functional subclasses: Protein-protein binding
Detection methods:
  1. Nuclear magnetic resonance (NMR) (278 K; pH: 7; D2O 7.5 %; SNCG (15N-labelled) 0.35 mM/L; sodium phosphate (buffer) 10 mM/L)

  2. Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 7; ANK peptide (binding partner); SNCG 0.145 mg/mL; sodium phosphate (buffer) 5 mM/L)

References:
  1. Singh VK, Zhou Y, Marsh JA, Uversky VN, Forman-Kay JD, Liu J, Jia Z. "Synuclein-gamma targeting peptide inhibitor that enhances sensitivity of breast cancer cells to antimicrotubule drugs." Cancer Res. 2007; 67(2): 626-33. PubMed: 17234772

Comments:
 



References

  1. Singh VK, Zhou Y, Marsh JA, Uversky VN, Forman-Kay JD, Liu J, Jia Z. "Synuclein-gamma targeting peptide inhibitor that enhances sensitivity of breast cancer cells to antimicrotubule drugs." Cancer Res. 2007; 67(2): 626-33. PubMed: 17234772



Comments


AV (7-27-2010) PubMed: 17234772


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