| General information | | DisProt: | DP00635 | | Name: | Class E vacuolar protein-sorting machinery protein HSE1 | | Synonym(s): | HSE1_YEAST
| | First appeared in release: | Release 5.4 (10/14/2010) | | UniProt: | P38753 | | UniGene: | | | SwissProt: | HSE1_YEAST | | TrEMBL: | | | NCBI (GI): | 731589 | | Source organism: | Saccharomyces cerevisiae (Baker's yeast) | | Sequence length: | 452 | | Percent disordered: | 13% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MSSSAIKIRN ALLKATDPKL RSDNWQYILD VCDLVKEDPE DNGQEVMSLI EKRLEQQDAN - 60
VILRTLSLTV SLAENCGSRL RQEISSKNFT SLLYALIESH SVHITLKKAV TDVVKQLSDS - 120
FKDDPSLRAM GDLYDKIKRK APYLVQPNVP EKHNMSTQAD NSDDEELQKA LKMSLFEYEK - 180
QKKLQEQEKE SAEVLPQQQQ QHQQQNQAPA HKIPAQTVVR RVRALYDLTT NEPDELSFRK - 240
GDVITVLEQV YRDWWKGALR GNMGIFPLNY VTPIVEPSKE EIEKEKNKEA IVFSQKTTID - 300
QLHNSLNAAS KTGNSNEVLQ DPHIGDMYGS VTPLRPQVTR MLGKYAKEKE DMLSLRQVLA - 360
NAERSYNQLM DRAANAHISP PVPGPALYAG MTHANNTPVM PPQRQSYQSN EYSPYPSNLP - 420
IQHPTNSANN TPQYGYDLGY SVVSQPPPGY EQ
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| Functional narrative |
Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane. (UniProt).
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | SH3 domain | | Location: | 217 - 276 | | Length: | 60 | | Region sequence: |
TVVRRVRALYDLTTNEPDELSFRKGDVITVLEQVYRDWWKGALRGNMGIFPLNYVTPIVE
| | Modification type: | Complex
Fragment
| | PDB: | 2PJW:A | | Structural/functional type: | Relationship to function unknown
| | Functional classes: | Molecular recognition effectors
| | Functional subclasses: | Protein-protein binding
| Detection methods:
- X-ray crystallography (Vps27/Hse1 core complex)
| References:
- Beltrao P, Serrano L. "Comparative genomics and disorder prediction identify biologically relevant SH3 protein interactions." PLoS Comput. Biol.. 2005; 1(3): e26. PubMed: 16110343
- Prag G, Watson H, Kim YC, Beach BM, Ghirlando R, Hummer G, Bonifacino JS, Hurley JH. "The Vps27/Hse1 complex is a GAT domain-based scaffold for ubiquitin-dependent sorting." Dev. Cell. 2007; 12(6): 973-86. PubMed: 17543868
| Comments:Crystal structure (PDB 2PJW) is from Prag et al. (2007).
Protein disorder discussion is from Beltrao and Serrano (2005).
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| References |
- Prag G, Watson H, Kim YC, Beach BM, Ghirlando R, Hummer G, Bonifacino JS, Hurley JH. "The Vps27/Hse1 complex is a GAT domain-based scaffold for ubiquitin-dependent sorting." Dev. Cell. 2007; 12(6): 973-86. PubMed: 17543868
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