| General information | | DisProt: | DP00637 | | Name: | Parathyroid hormone | | Synonym(s): | PTHY_HUMAN
PTH
Parathyrin
Parathormone
| | First appeared in release: | Release 5.2 (08/07/2010) | | UniProt: | P01270 | | UniGene: | Hs.37045 | | SwissProt: | PTHY_HUMAN | | TrEMBL: | | | NCBI (GI): | 131547 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 115 | | Percent disordered: | 30% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MIPAKDMAKV MIVMLAICFL TKSDGKSVKK RSVSEIQLMH NLGKHLNSME RVEWLRKKLQ - 60
DVHNFVALGA PLAPRDAGSQ RPRKKEDNVL VESHEKSLGE ADKADVNVLT KAKSQ
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| Functional narrative |
PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | hPTH-(1-34) | | Location: | 32 - 65 | | Length: | 34 | | Region sequence: |
SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNF | | Modification type: | Fragment
Native
| | PDB: | 1ET1:A | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | | | Functional subclasses: | Intraprotein interaction
Substrate/ligand binding
Protein-protein binding
| Detection methods:
- X-ray crystallography (293 K; pH: 4.5; ammonium sulfate 2.5 M; isopropanol 5 %; sodium acetate buffer 0.1 M)
| References:
- Jin L, Briggs SL, Chandrasekhar S, Chirgadze NY, Clawson DK, Schevitz RW, Smiley DL, Tashjian AH, Zhang F. "Crystal structure of human parathyroid hormone 1-34 at 0.9-A resolution." J. Biol. Chem.. 2000; 275(35): 27238-44. PubMed: 10837469
- Shimizu N, Guo J, Gardella TJ. "Parathyroid hormone (PTH)-(1-14) and -(1-11) analogs conformationally constrained by alpha-aminoisobutyric acid mediate full agonist responses via the juxtamembrane region of the PTH-1 receptor." J Biol Chem. 2001; 276(52): 49003-12. PubMed: 11604398
| Comments:Jin, et al. (2000), found that the dimer formed during crystallization is unlikely to form under physiological conditions.
Shimizu et al. (2001) discuss conformational constraint of PHT upon interaction with the activation domain of PHT-1 receptor.
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| References |
- Jin L, Briggs SL, Chandrasekhar S, Chirgadze NY, Clawson DK, Schevitz RW, Smiley DL, Tashjian AH, Zhang F. "Crystal structure of human parathyroid hormone 1-34 at 0.9-A resolution." J. Biol. Chem.. 2000; 275(35): 27238-44. PubMed: 10837469
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| Comments |
AV (8-2-2010) PubMed: 10837469
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