| General information | | DisProt: | DP00641 | | Name: | Eotaxin | | Synonym(s): | CCL11_HUMAN
C-C motif chemokine 11
Small-inducible cytokine A11
Eosinophil chemotactic protein
| | First appeared in release: | Release 5.2 (08/07/2010) | | UniProt: | P51671 | | UniGene: | Hs.54460 | | SwissProt: | CCL11_HUMAN | | TrEMBL: | | | NCBI (GI): | 1706661 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 97 | | Percent disordered: | 8% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MKVSAALLWL LLIAAAFSPQ GLAGPASVPT TCCFNLANRK IPLQRLESYR RITSGKCPQK - 60
AVIFKTKLAK DICADPKKKW VQDSMKYLDQ KSPTPKP
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| Functional narrative |
In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | N-terminal | | Location: | 1 - 8 | | Length: | 8 | | Region sequence: |
MKVSAALL | | Modification type: | Monomeric
Native
| | PDB: | 1EOT:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | Substrate/ligand binding
| Detection methods:
- Nuclear magnetic resonance (NMR) (283 K; pH: 5; protein (sample) 2 mM; sodium 2,2-dimethyl-2-silapentane sulfonate 1 mM; sodium acetate 20 mM; sodium azide 1 mM; Varian Inova (spectrometer) 500 MHz; Varian Unity (spectrometer) 600 MHz)
- Analytical ultracentrifugation (298 K; pH: 5; Beckman Spinco model E (analytical ultracentrifuge); NaCl 100 mM; protein (sample) 1 mg/mL; rotor speed 26000 rpm; sodium phosphate 50 mM)
| References:
- Crump MP, Rajarathnam K, Kim KS, Clark-Lewis I, Sykes BD. "Solution structure of eotaxin, a chemokine that selectively recruits eosinophils in allergic inflammation." J Biol Chem. 1998; 273(35): 22471-22479. PubMed: 9712872
| Comments:
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