| General information | | DisProt: | DP00643 | | Name: | Bcl-2-like protein 11 | | Synonym(s): | B2L11_HUMAN
Bcl2-L-11
Bcl2-interacting mediator of cell death
| | First appeared in release: | Release 5.1 (05/28/2010) | | UniProt: | O43521 | | UniGene: | Hs.469658 | | SwissProt: | B2L11_HUMAN | | TrEMBL: | | | NCBI (GI): | 18202042 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 198 | | Percent disordered: | -1% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP - 60
QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP - 120
CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPR - 180
MVILRLLRYI VRLVWRMH
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| Functional narrative |
Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than the isoforms BimEL, BimL and BimS. Isoform Bim-gamma induces apoptosis.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| References |
- Hinds MG, Smits C, Fredericks-Short R, Risk JM, Bailey M, Huang DC, Day CL. "Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets." Cell Death Differ. 2006. PubMed: 16645638
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| Comments |
This protein is the parent protein of DP00643_A002, Isoform BimEL.
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