| General information | | DisProt: | DP00647 | | Name: | Lipocalin-1 | | Synonym(s): | LCN1_HUMAN
Von Ebner gland protein
VEG protein
Tear prealbumin
TP
Tear lipocalin
Tlc
| | First appeared in release: | Release 5.1 (05/28/2010) | | UniProt: | P31025 | | UniGene: | Hs.530311 | | SwissProt: | LCN1_HUMAN | | TrEMBL: | | | NCBI (GI): | 401346 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 176 | | Percent disordered: | 4% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MKPLLLAVSL GLIAALQAHH LLASDEEIQD VSGTWYLKAM TVDREFPEMN LESVTPMTLT - 60
TLEGGNLEAK VTMLISGRCQ EVKAVLEKTD EPGKYTADGG KHVAYIIRSH VKDHYIFYCE - 120
GELHGKPVRG VKLVGRDPKN NLEALEDFEK AAGARGLSTE SILIPRQSET CSPGSD
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| Functional narrative |
Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 5 - 11 | | Length: | 7 | | Region sequence: |
LLAVSLG | | Modification type: | Native
| | PDB: | 1XKI:A, 3EYC:A | | Structural/functional type: | | | Functional classes: | Molecular recognition effectors
| | Functional subclasses: | Substrate/ligand binding
| Detection methods:
- Size exclusion/gel filtration chromatography (293 K; pH: 8; )
| References:
- Breusted DA, Chatwell L, Skerra A. "A new crystal form of human tear lipocalin reveals high flexibility in the loop region and induced fit in the ligand cavity." Acta Crystallogr D Biol Crystallogr. 2009; 65(Pt 10): 1118-25. PubMed: 19770509
- Breustedt DA, Korndörfer IP, Redl B, Skerra A. "The 1.8-A crystal structure of human tear lipocalin reveals an extended branched cavity with capacity for multiple ligands." J Biol Chem. 2005; 280(1): 484-93. PubMed: 15489503
| Comments:
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