General information | DisProt: | DP00655 | Name: | Fermitin family homolog 1 | Synonym(s): | FERM1_MOUSE
Unc-112-related protein 1
Kindlin-1
| First appeared in release: | Release 5.1 (05/28/2010) | UniProt: | P59113 | UniGene: | Mm.209784 | SwissProt: | FERM1_MOUSE | TrEMBL: | | NCBI (GI): | 122066624 | Source organism: | Mus musculus (Mouse) | Sequence length: | 677 | Percent disordered: | 16% | Homologues: | |
Native sequence |
10 20 30 40 50 60 | | | | | | MLSSGDLTSA SWELVVRVDH ANGEQQTEIT LRVSGDLHIG GVMLKLVEQM NIAQDWSDYA - 60 LWWEQKRCWL LKTHWTLDKC GVQADANLLF TPQHKMLRLR LPNAKTVRLR VSFSAVVFKA - 120 VADICKVLNI RRPEELSLLK PSSDYCKKKK KKEKNSKEPV IEDILNLESS STSSGSPVSP - 180 GLYSKTMTPT YDPINGTPAL STMTWFGDSP LTEQNCSVLA FSQPPPSPDV LADMFQPRSL - 240 VDKAKMNAGW LDSSRSLMEQ SIQEDEQLQL RFKYYTFFDL NPKYDAVRIN QLYEQARWAV - 300 LLEEIDCTEE EMLIFAALQY HISKLSQCAE IQDFATKSEV DEVEAALSSL EVTLEGGKAD - 360 NTLEDITDIP KLADYLKLFR PKKLMLKACK QYWFVFKDTS IAYFKNKELE QGEPIEKLNL - 420 RGCEIVPDVN VSGRKFGIKL LIPVADGMNE VYLRCDHEDQ YARWMAACIL ASKGKTMADS - 480 SYQPEVISIL SFLKMKNRNS SPLVASSLEN MDMNPECLVS PRCAKKHKSK QLAARILEAH - 540 HNVAQMPLVE AKLQFIQAWQ SLPEFGLTYY LVRFKGSKKD DILGVSYNRL IRIDAVTGIP - 600 VTTWRFANMK QWNVNWEIRQ VAIEFDQNVS IAFTCLSADC KIVHEYIGGY IFLSTRSKDQ - 660 NETLDEDLFH KLTGGQD
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Functional narrative |
Involved in cell adhesion, possibly via its interaction with integrins.
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Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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Region 1 | Type: | Disordered | Name: | F1 Loop | Location: | 141 - 250 | Length: | 110 | Region sequence: |
PSSDYCKKKKKKEKNSKEPVIEDILNLESSSTSSGSPVSPGLYSKTMTPTYDPINGTPAL STMTWFGDSPLTEQNCSVLAFSQPPPSPDVLADMFQPRSLVDKAKMNAGW | Modification type: | Native
| PDB: | 2KMC:A | Structural/functional type: | | Functional classes: | | Functional subclasses: | | Detection methods:
- Nuclear magnetic resonance (NMR) (298 K; pH: 6.5; 2H2O (v/v) 10 %; DTT 2 mM; NaCl (buffer) 50 mM; protein (sample) 0.5 mM; sodium phosphate (buffer) 20 mM)
| References:
- Goult BT, Bouaouina M, Harburger DS, Bate N, Patel B, Anthis NJ, Campbell ID, Calderwood DA, Barsukov IL, Roberts GC, Critchley DR. "The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation." J Mol Biol. 2009; 394(5): 944-56. PubMed: 19804783
| Comments:
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References |
- Goult BT, Bouaouina M, Harburger DS, Bate N, Patel B, Anthis NJ, Campbell ID, Calderwood DA, Barsukov IL, Roberts GC, Critchley DR. "The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation." J Mol Biol. 2009; 394(5): 944-56. PubMed: 19804783
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