| General information | | DisProt: | DP00668 | | Name: | Thermostable direct hemolysin 2 | | Synonym(s): | HLY2_VIBPA
TDH
Kanagawa phenomenon-associated hemolysin
| | First appeared in release: | Release 5.3 (09/21/2010) | | UniProt: | P19250 | | UniGene: | | | SwissProt: | HLY2_VIBPA | | TrEMBL: | | | NCBI (GI): | | | Source organism: | Vibrio parahaemolyticus | | Sequence length: | 189 | | Percent disordered: | 6% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MKYRYFAKKS FLFISMLAAF KTFAFELPSV PFPAPGSDEI LFVVRDTTFN TNAPVNVEVS - 60
DFWTNRNVKR KPYKDVYGQS VFTTSGTKWL TSYMTVNIND KDYTMAAVSG YKHGHSAVFV - 120
KSDQVQLQHS YDSVANFVGE DEDSIPSKMY LDETPEYFVN VEAYESGSGN ILVMCISNKE - 180
SFFECKHQQ
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| Functional narrative |
Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined. Belongs to the TDH hemolysin family.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | N-terminal region | | Location: | 1 - 11 | | Length: | 11 | | Region sequence: |
MKYRYFAKKSF | | Modification type: | Native
| | PDB: | 3A57:A | | Structural/functional type: | Relationship to function unknown
| | Functional classes: | Unknown
| | Functional subclasses: | Unknown
| Detection methods:
- X-ray crystallography (293 K; pH: 10.6; CAPS 100 mM; Lithium sulfate 1 M)
| References:
- Yanagihara I, Nakahira K, Yamane T, Kaieda S, Mayanagi K, Hamada D, Fukui T, Ohnishi K, Kajiyama S, Shimizu T, Sato M, Ikegami T, Ikeguchi M, Honda T, Hashimoto H. "Structure and functional characterization of Vibrio parahaemolyticus thermostable direct hemolysin." J. Biol. Chem.. 2010; 285(21): 16267-74. PubMed: 20335168
| Comments:
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| References |
- Yanagihara I, Nakahira K, Yamane T, Kaieda S, Mayanagi K, Hamada D, Fukui T, Ohnishi K, Kajiyama S, Shimizu T, Sato M, Ikegami T, Ikeguchi M, Honda T, Hashimoto H. "Structure and functional characterization of Vibrio parahaemolyticus thermostable direct hemolysin." J. Biol. Chem.. 2010; 285(21): 16267-74. PubMed: 20335168
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| Comments |
Sent for AV 9-21-2010 (PubMed: 20335168)
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