| General information | | DisProt: | DP00670 | | Name: | MHC class I polypeptide-related sequence A | | Synonym(s): | MICA_HUMAN
MIC-A
| | First appeared in release: | Release 5.2 (08/07/2010) | | UniProt: | Q29983 | | UniGene: | Hs.130838 | | SwissProt: | MICA_HUMAN | | TrEMBL: | | | NCBI (GI): | 74740024 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 383 | | Percent disordered: | 3% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MGLGPVFLLL AGIFPFAPPG AAAEPHSLRY NLTVLSWDGS VQSGFLTEVH LDGQPFLRCD - 60
RQKCRAKPQG QWAEDVLGNK TWDRETRDLT GNGKDLRMTL AHIKDQKEGL HSLQEIRVCE - 120
IHEDNSTRSS QHFYYDGELF LSQNLETKEW TMPQSSRAQT LAMNVRNFLK EDAMKTKTHY - 180
HAMHADCLQE LRRYLKSGVV LRRTVPPMVN VTRSEASEGN ITVTCRASGF YPWNITLSWR - 240
QDGVSLSHDT QQWGDVLPDG NGTYQTWVAT RICQGEEQRF TCYMEHSGNH STHPVPSGKV - 300
LVLQSHWQTF HVSAVAAAAI FVIIIFYVRC CKKKTSAAEG PELVSLQVLD QHPVGTSDHR - 360
DATQLGFQPL MSDLGSTGST EGA
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| Functional narrative |
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 152 - 161 | | Length: | 10 | | Region sequence: |
MPQSSRAQTL | | Modification type: | Native
| | PDB: | 1B3J:A | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | | | Functional subclasses: | Substrate/ligand binding
| Detection methods:
- X-ray crystallography (103 K; Rigaku R-AXIS II or R-AXIS IV (area detector))
| References:
- Li P, Willie ST, Bauer S, Morris DL, Spies T, Strong RK. "Crystal structure of the MHC class I homolog MIC-A, a gammadelta T cell ligand." Immunity. 1999; 10(5): 577-584. PubMed: 10367903
| Comments:
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| References |
- Huang Y, Liu Z. "Kinetic advantage of intrinsically disordered proteins in coupled folding-binding process: a critical assessment of the "fly-casting" mechanism." J Mol Biol. 2009; 393(5): 1143-1159. PubMed: 19747922
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| Comments |
AV (8-3-2010) PubMed: 19747922
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