DP00671: Nuclear factor erythroid 2-related factor 1FASTA viewXML view

General information
DisProt:DP00671
Name:Nuclear factor erythroid 2-related factor 1
Synonym(s):NF2L1_MOUSE
NF-E2-related factor 1
NFE2-related factor 1
Nuclear factor, erythroid derived 2, like 1
First appeared in release:Release 5.2 (08/07/2010)
UniProt:Q61985
UniGene:Mm.6743
SwissProt: NF2L1_MOUSE
TrEMBL:  
NCBI (GI): 3183180
Source organism:Mus musculus (Mouse)
Sequence length:741
Percent disordered:13%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MLSLKKYLTE GLLQFTILLS LIGVRVDVDT YLTSQLPPLR EIILGPSSAY TQTQFHNLRN - 60
TLDGYGIHPK SIDLDNYFTA RRLLSQVRAL DRFQVPTTEV NAWLVHRDPE GSVSGSQPNS - 120
GLALESSSGL QDVTGPDNGV RESETEQGFG EDLEDLGAVA PPVSGDLTKE DIDLIDILWR - 180
QDIDLGAGRE VFDYSHRQKE QDVDKELQDG REREDTWSGE GAEALARDLL VDGETGESFP - 240
AQFPADVSSI PEAVPSESES PALQNSLLSP LLTGTESPFD LEQQWQDLMS IMEMQAMEVN - 300
TSASEILYNA PPGDPLSSNY SLAPNTPINQ NVSLHQASLG GCSQDFSLFS PEVESLPVAS - 360
SSTLLPLVPS NSTSLNSTFG STNLAGPFFP SQLNGTANDT SGPELPDPLG GLLDEAMLDE - 420
ISLMDLAIEE GFNPVQASQL EEEFDSDSGL SLDSSHSPSS LSSSEGSSSS SSSSSSSSAS - 480
SSASSSFSEE GAVGYSSDSE TLDLEEAEGA VGYQPEYSKF CRMSYQDPSQ LSCLPYLEHV - 540
GHNHTYNMAP SALDSADLPP PSTLKKGSKE KQADFLDKQM SRDEHRARAM KIPFTNDKII - 600
NLPVEEFNEL LSKYQLSEAQ LSLIRDIRRR GKNKMAAQNC RKRKLDTILN LERDVEDLQR - 660
DKARLLREKV EFLRSLRQMK QKVQSLYQEV FGRLRDEHGR PYSPSQYALQ YAGDGSVLLI - 720
PRTMADQQAR RQERKPKDRR K



Functional narrative    

The short isoform interacts with the extended kappa 3 site of the TNF alpha promoter after Fc gamma RIII stimulation and participates in the induction of this cytokine. The long isoform is either inactive or represses the transcriptional activation.Phosphorylation by CKII could regulate DNA-binding activity. Belongs to the bZIP family. CNC subfamily. Contains 1 bZIP domain.

Region 1: 1-98

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name:Neh2 domain
Location:1 - 98
Length:98
Region sequence:

MLSLKKYLTEGLLQFTILLSLIGVRVDVDTYLTSQLPPLREIILGPSSAYTQTQFHNLRN
TLDGYGIHPKSIDLDNYFTARRLLSQVRALDRFQVPTT

Modification type: Native
PDB:  
Structural/functional type:  
Functional classes: Molecular recognition effectors
Functional subclasses: Protein-protein binding
Detection methods:
  1. Analytical ultracentrifugation (298 K; Beckman Optima XL-I (analytical ultracentrifuge); protein (concentration) 155 uM; rotor speed 60000 rpm)

  2. Nuclear magnetic resonance (NMR) (298 K; Varian UNITY INOVA 500 or a Bruker AVANCE DRX 800 (spectrometer))

References:
  1. Tong KI, Katoh Y, Kusunoki H, Itoh K, Tanaka T, Yamamoto M. "Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model." Mol Cell Biol. 2006; 26(8): 2887-900. PubMed: 16581765

Comments:
 



References

  1. Tong KI, Katoh Y, Kusunoki H, Itoh K, Tanaka T, Yamamoto M. "Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model." Mol Cell Biol. 2006; 26(8): 2887-900. PubMed: 16581765



Comments


AV (8-3-2010) PubMed: 16581765


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