DP00673_C001: Protein CFASTA viewXML view

General information
DisProt:DP00673_C001
Name:Protein C
Synonym(s):POLG_WNV
Core protein
Capsid protein
cleavage product 1 of Genome polyprotein
First appeared in release:Release 5.1 (05/28/2010)
UniProt:P06935
UniGene: 
SwissProt: POLG_WNV
TrEMBL:  
NCBI (GI): 37999909
Source organism:West Nile virus (WNV)
Sequence length:105
Percent disordered:48%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MSKKPGGPGK NRAVNMLKRG MPRGLSLIGL KRAMLSLIDG KGPIRFVLAL LAFFRFTAIA - 60
PTRAVLDRWR GVNKQTAMKH LLSFKKELGT LTSAINRRST KQKKR



Functional narrative    

The virion of this virus is a nucleocapsid covered by a lipoprotein envelope. The envelope contains two proteins: the protein M and glycoprotein E. The nucleocapsid is a complex of protein C and mRNA. In immature particles, there are 60 icosaedrally organized trimeric spikes on the surface. Each spike consists of three heterodimers of envelope protein M precursor (prM) and envelope protein E. Protein C is cleavage product 1 of Genome polyprotein, comprising aa 2-123 of the polyprotein.

Region 1: 1-24 Region 2: 80-105

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:1 - 24
Length:24
Region sequence:

MSKKPGGPGKNRAVNMLKRGMPRG

Modification type: Native
PDB:  
Structural/functional type: Relationship to function unknown
Functional classes: Chaperones
Functional subclasses: Unknown
Detection methods:
  1. Circular dichroism (CD) spectroscopy, far-UV (293 K; pH: 7.4; 2-mercaptoethanol 5 mM; path-length (quartz cuvette (Hellma)) 0.02 cm; protein (sample) 20 uM; sodium phosphate (buffer) 20 mM)

References:
  1. Ivanyi-Nagy R, Lavergne JP, Gabus C, Ficheux D, Darlix JL. "RNA chaperoning and intrinsic disorder in the core proteins of Flaviviridae." Nucleic Acids Res. 2008; 36(3): 712-725. PubMed: 18033802

Comments:
 



Region 2
Type:Disordered
Name: 
Location:80 - 105
Length:26
Region sequence:

HLLSFKKELGTLTSAINRRSTKQKKR

Modification type: Native
PDB:  
Structural/functional type: Relationship to function unknown
Functional classes: Chaperones
Functional subclasses: Unknown
Detection methods:
  1. Circular dichroism (CD) spectroscopy, far-UV (293 K; pH: 7.4; 2-mercaptoethanol 5 mM; path-length (quartz cuvette (Hellma)) 0.02 cm; protein (sample) 20 uM; sodium phosphate (buffer) 20 mM)

References:
  1. Ivanyi-Nagy R, Lavergne JP, Gabus C, Ficheux D, Darlix JL. "RNA chaperoning and intrinsic disorder in the core proteins of Flaviviridae." Nucleic Acids Res. 2008; 36(3): 712-725. PubMed: 18033802

Comments:
 


If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us.


Disprot-footer
Contact us