DP00674: Genome polyproteinFASTA viewXML view

General information
DisProt:DP00674
Name:Genome polyprotein
Synonym(s):POLG_GBVB
Core protein [cleavage product 1]
Envelope glycoprotein E1 [cleavage product 2]
Envelope glycoprotein E2 [cleavage product 3]
NS1
p13 [cleavage product 4]
p6 [cleavage product 5]
p7 [cleavage product 6]
Protease NS2-3 [cleavage product 7]
Serine protease/NTPase/helicase NS3 [cleavage product 8]
EC=3.4.21.98
EC=3.6.1.15
Hepacivirin
NS3P
Non-structural protein 4A [cleavage product 9]
NS4A
Non-structural protein 4B [cleavage product 10]
NS4B
Non-structural protein 5A [cleavage product 11]
NS5A
RNA-directed RNA polymerase [cleavage product 12]
EC=2.7.7.48
NS5B
First appeared in release:Release 5.1 (05/28/2010)
UniProt:Q69422
UniGene: 
SwissProt: POLG_GBVB
TrEMBL:  
NCBI (GI): 68565638
Source organism:Hepatitis GB virus B (GBV-B) (GB virus B)
Sequence length:2864
Percent disordered:-1%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MPVISTQTSP VPAPRTRKNK QTQASYPVSI KTSVERGQRA KRKVQRDARP RNYKIAGIHD - 60
GLQTLAQAAL PAHGWGRQDP RHKSRNLGIL LDYPLGWIGD VTTHTPLVGP LVAGAVVRPV - 120
CQIVRLLEDG VNWATGWFGV HLFVVCLLSL ACPCSGARVT DPDTNTTILT NCCQRNQVIY - 180
CSPSTCLHEP GCVICADECW VPANPYISHP SNWTGTDSFL ADHIDFVMGA LVTCDALDIG - 240
ELCGACVLVG DWLVRHWLIH IDLNETGTCY LEVPTGIDPG FLGFIGWMAG KVEAVIFLTK - 300
LASQVPYAIA TMFSSVHYLA VGALIYYASR GKWYQLLLAL MLYIEATSGN PIRVPTGCSI - 360
AEFCSPLMIP CPCHSYLSEN VSEVICYSPK WTRPVTLEYN NSISWYPYTI PGARGCMVKF - 420
KNNTWGCCRI RNVPSYCTMG TDAVWNDTRN TYEACGVTPW LTTAWHNGSA LKLAILQYPG - 480
SKEMFKPHNW MSGHLYFEGS DTPIVYFYDP VNSTLLPPER WARLPGTPPV VRGSWLQVPQ - 540
GFYSDVKDLA TGLITKDKAW KNYQVLYSAT GALSLTGVTT KAVVLILLGL CGSKYLILAY - 600
LCYLSLCFGR ASGYPLRPVL PSQSYLQAGW DVLSKAQVAP FALIFFICCY LRCRLRYAAL - 660
LGFVPMAAGL PLTFFVAAAA AQPDYDWWVR LLVAGLVLWA GRDRGPRIAL LVGPWPLVAL - 720
LTLLHLATPA SAFDTEIIGG LTIPPVVALV VMSRFGFFAH LLPRCALVNS YLWQRWENWF - 780
WNVTLRPERF LLVLVCFPGA TYDTLVTFCV CHVALLCLTS SAASFFGTDS RVRAHRMLVR - 840
LGKCHAWYSH YVLKFFLLVF GENGVFFYKH LHGDVLPNDF ASKLPLQEPF FPFEGKARVY - 900
RNEGRRLACG DTVDGLPVVA RLGDLVFAGL AMPPDGWAIT APFTLQCLSE RGTLSAMAVV - 960
MTGIDPRTWT GTIFRLGSLA TSYMGFVCDN VLYTAHHGSK GRRLAHPTGS IHPITVDAAN - 1020
DQDIYQPPCG AGSLTRCSCG ETKGYLVTRL GSLVEVNKSD DPYWCVCGAL PMAVAKGSSG - 1080
APILCSSGHV IGMFTAARNS GGSVSQIRVR PLVCAGYHPQ YTAHATLDTK PTVPNEYSVQ - 1140
ILIAPTGSGK STKLPLSYMQ EKYEVLVLNP SVATTASMPK YMHATYGVNP NCYFNGKCTN - 1200
TGASLTYSTY GMYLTGACSR NYDVIICDEC HATDATTVLG IGKVLTEAPS KNVRLVVLAT - 1260
ATPPGVIPTP HANITEIQLT DEGTIPFHGK KIKEENLKKG RHLIFEATKK HCDELANELA - 1320
RKGITAVSYY RGCDISKIPE GDCVVVATDA LCTGYTGDFD SVYDCSLMVE GTCHVDLDPT - 1380
FTMGVRVCGV SAIVKGQRRG RTGRGRAGIY YYVDGSCTPS GMVPECNIVE AFDAAKAWYG - 1440
LSSTEAQTIL DTYRTQPGLP AIGANLDEWA DLFSMVNPEP SFVNTAKRTA DNYVLLTAAQ - 1500
LQLCHQYGYA APNDAPRWQG ARLGKKPCGV LWRLDGADAC PGPEPSEVTR YQMCFTEVNT - 1560
SGTAALAVGV GVAMAYLAID TFGATCVRRC WSITSVPTGA TVAPVVDEEE IVEECASFIP - 1620
LEAMVAAIDK LKSTITTTSP FTLETALEKL NTFLGPHAAT ILAIIEYCCG LVTLPDNPFA - 1680
SCVFAFIAGI TTPLPHKIKM FLSLFGGAIA SKLTDARGAL AFMMAGAAGT ALGTWTSVGF - 1740
VFDMLGGYAA ASSTACLTFK CLMGEWPTMD QLAGLVYSAF NPAAGVVGVL SACAMFALTT - 1800
AGPDHWPNRL LTMLARSNTV CNEYFIATRD IRRKILGILE ASTPWSVISA CIRWLHTPTE - 1860
DDCGLIAWGL EIWQYVCNFF VICFNVLKAG VQSMVNIPGC PFYSCQKGYK GPWIGSGMLQ - 1920
ARCPCGAELI FSVENGFAKL YKGPRTCSNY WRGAVPVNAR LCGSARPDPT DWTSLVVNYG - 1980
VRDYCKYEKL GDHIFVTAVS SPNVCFTQVP PTLRAAVAVD GVQVQCYLGE PKTPWTTSAC - 2040
CYGPDGKGKT VKLPFRVDGH TPGVRMQLNL RDALETNDCN SINNTPSDEA AVSALVFKQE - 2100
LRRTNQLLEA ISAGVDTTKL PAPSIEEVVV RKRQFRARTG SLTLPPPPRS VPGVSCPESL - 2160
QRSDPLEGPS NLPSSPPVLQ LAMPMPLLGA GECNPFTAIG CAMTETGGGP DDLPSYPPKK - 2220
EVSEWSDGSW STTTTASSYV TGPPYPKIRG KDSTQSAPAK RPTKKKLGKS EFSCSMSYTW - 2280
TDVISFKTAS KVLSATRAIT SGFLKQRSLV YVTEPRDAEL RKQKVTINRQ PLFPPSYHKQ - 2340
VRLAKEKASK VVGVMWDYDE VAAHTPSKSA KSHITGLRGT DVRSGAARKA VLDLQKCVEA - 2400
GEIPSHYRQT VIVPKEEVFV KTPQKPTKKP PRLISYPHLE MRCVEKMYYG QVAPDVVKAV - 2460
MGDAYGFVDP RTRVKRLLSM WSPDAVGATC DTVCFDSTIT PEDIMVETDI YSAAKLSDQH - 2520
RAGIHTIARQ LYAGGPMIAY DGREIGYRRC RSSGVYTTSS SNSLTCWLKV NAAAEQAGMK - 2580
NPRFLICGDD CTVIWKSAGA DADKQAMRVF ASWMKVMGAP QDCVPQPKYS LEELTSCSSN - 2640
VTSGITKSGK PYYFLTRDPR IPLGRCSAEG LGYNPSAAWI GYLIHHYPCL WVSRVLAVHF - 2700
MEQMLFEDKL PETVTFDWYG KNYTVPVEDL PSIIAGVHGI EAFSVVRYTN AEILRVSQSL - 2760
TDMTMPPLRA WRKKARAVLA SAKRRGGAHA KLARFLLWHA TSRPLPDLDK TSVARYTTFN - 2820
YCDVYSPEGD VFVTPQRRLQ KFLVKYLAVI VFALGLIAVG LAIS



Functional narrative    

Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Probably also regulates many host cellular functions such as antiviral state inhibition, cell transformation and apoptosis. Envelope glycoproteins E1 and E2 are involved in virus attachment to the host cell as well as in virus endocytosis and fusion with host membrane. P13 may function as a multimeric ion channel protein (viroporin). Protease NS2-3 is a cysteine protease responsible for the autocatalytic cleavage of NS2-NS3. NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B By similarity. NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction and likely RNA stable secondary structure in the template strand. Cleaves and inhibits the human antiviral protein MAVS. NS5A is a component of the replication complex involved in RNA-binding. NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication.



Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.

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