General information | DisProt: | DP00674 | Name: | Genome polyprotein | Synonym(s): | POLG_GBVB
Core protein [cleavage product 1]
Envelope glycoprotein E1 [cleavage product 2]
Envelope glycoprotein E2 [cleavage product 3]
NS1
p13 [cleavage product 4]
p6 [cleavage product 5]
p7 [cleavage product 6]
Protease NS2-3 [cleavage product 7]
Serine protease/NTPase/helicase NS3 [cleavage product 8]
EC=3.4.21.98
EC=3.6.1.15
Hepacivirin
NS3P
Non-structural protein 4A [cleavage product 9]
NS4A
Non-structural protein 4B [cleavage product 10]
NS4B
Non-structural protein 5A [cleavage product 11]
NS5A
RNA-directed RNA polymerase [cleavage product 12]
EC=2.7.7.48
NS5B
| First appeared in release: | Release 5.1 (05/28/2010) | UniProt: | Q69422 | UniGene: | | SwissProt: | POLG_GBVB | TrEMBL: | | NCBI (GI): | 68565638 | Source organism: | Hepatitis GB virus B (GBV-B) (GB virus B) | Sequence length: | 2864 | Percent disordered: | -1% | Homologues: | |
Native sequence |
10 20 30 40 50 60 | | | | | | MPVISTQTSP VPAPRTRKNK QTQASYPVSI KTSVERGQRA KRKVQRDARP RNYKIAGIHD - 60 GLQTLAQAAL PAHGWGRQDP RHKSRNLGIL LDYPLGWIGD VTTHTPLVGP LVAGAVVRPV - 120 CQIVRLLEDG VNWATGWFGV HLFVVCLLSL ACPCSGARVT DPDTNTTILT NCCQRNQVIY - 180 CSPSTCLHEP GCVICADECW VPANPYISHP SNWTGTDSFL ADHIDFVMGA LVTCDALDIG - 240 ELCGACVLVG DWLVRHWLIH IDLNETGTCY LEVPTGIDPG FLGFIGWMAG KVEAVIFLTK - 300 LASQVPYAIA TMFSSVHYLA VGALIYYASR GKWYQLLLAL MLYIEATSGN PIRVPTGCSI - 360 AEFCSPLMIP CPCHSYLSEN VSEVICYSPK WTRPVTLEYN NSISWYPYTI PGARGCMVKF - 420 KNNTWGCCRI RNVPSYCTMG TDAVWNDTRN TYEACGVTPW LTTAWHNGSA LKLAILQYPG - 480 SKEMFKPHNW MSGHLYFEGS DTPIVYFYDP VNSTLLPPER WARLPGTPPV VRGSWLQVPQ - 540 GFYSDVKDLA TGLITKDKAW KNYQVLYSAT GALSLTGVTT KAVVLILLGL CGSKYLILAY - 600 LCYLSLCFGR ASGYPLRPVL PSQSYLQAGW DVLSKAQVAP FALIFFICCY LRCRLRYAAL - 660 LGFVPMAAGL PLTFFVAAAA AQPDYDWWVR LLVAGLVLWA GRDRGPRIAL LVGPWPLVAL - 720 LTLLHLATPA SAFDTEIIGG LTIPPVVALV VMSRFGFFAH LLPRCALVNS YLWQRWENWF - 780 WNVTLRPERF LLVLVCFPGA TYDTLVTFCV CHVALLCLTS SAASFFGTDS RVRAHRMLVR - 840 LGKCHAWYSH YVLKFFLLVF GENGVFFYKH LHGDVLPNDF ASKLPLQEPF FPFEGKARVY - 900 RNEGRRLACG DTVDGLPVVA RLGDLVFAGL AMPPDGWAIT APFTLQCLSE RGTLSAMAVV - 960 MTGIDPRTWT GTIFRLGSLA TSYMGFVCDN VLYTAHHGSK GRRLAHPTGS IHPITVDAAN - 1020 DQDIYQPPCG AGSLTRCSCG ETKGYLVTRL GSLVEVNKSD DPYWCVCGAL PMAVAKGSSG - 1080 APILCSSGHV IGMFTAARNS GGSVSQIRVR PLVCAGYHPQ YTAHATLDTK PTVPNEYSVQ - 1140 ILIAPTGSGK STKLPLSYMQ EKYEVLVLNP SVATTASMPK YMHATYGVNP NCYFNGKCTN - 1200 TGASLTYSTY GMYLTGACSR NYDVIICDEC HATDATTVLG IGKVLTEAPS KNVRLVVLAT - 1260 ATPPGVIPTP HANITEIQLT DEGTIPFHGK KIKEENLKKG RHLIFEATKK HCDELANELA - 1320 RKGITAVSYY RGCDISKIPE GDCVVVATDA LCTGYTGDFD SVYDCSLMVE GTCHVDLDPT - 1380 FTMGVRVCGV SAIVKGQRRG RTGRGRAGIY YYVDGSCTPS GMVPECNIVE AFDAAKAWYG - 1440 LSSTEAQTIL DTYRTQPGLP AIGANLDEWA DLFSMVNPEP SFVNTAKRTA DNYVLLTAAQ - 1500 LQLCHQYGYA APNDAPRWQG ARLGKKPCGV LWRLDGADAC PGPEPSEVTR YQMCFTEVNT - 1560 SGTAALAVGV GVAMAYLAID TFGATCVRRC WSITSVPTGA TVAPVVDEEE IVEECASFIP - 1620 LEAMVAAIDK LKSTITTTSP FTLETALEKL NTFLGPHAAT ILAIIEYCCG LVTLPDNPFA - 1680 SCVFAFIAGI TTPLPHKIKM FLSLFGGAIA SKLTDARGAL AFMMAGAAGT ALGTWTSVGF - 1740 VFDMLGGYAA ASSTACLTFK CLMGEWPTMD QLAGLVYSAF NPAAGVVGVL SACAMFALTT - 1800 AGPDHWPNRL LTMLARSNTV CNEYFIATRD IRRKILGILE ASTPWSVISA CIRWLHTPTE - 1860 DDCGLIAWGL EIWQYVCNFF VICFNVLKAG VQSMVNIPGC PFYSCQKGYK GPWIGSGMLQ - 1920 ARCPCGAELI FSVENGFAKL YKGPRTCSNY WRGAVPVNAR LCGSARPDPT DWTSLVVNYG - 1980 VRDYCKYEKL GDHIFVTAVS SPNVCFTQVP PTLRAAVAVD GVQVQCYLGE PKTPWTTSAC - 2040 CYGPDGKGKT VKLPFRVDGH TPGVRMQLNL RDALETNDCN SINNTPSDEA AVSALVFKQE - 2100 LRRTNQLLEA ISAGVDTTKL PAPSIEEVVV RKRQFRARTG SLTLPPPPRS VPGVSCPESL - 2160 QRSDPLEGPS NLPSSPPVLQ LAMPMPLLGA GECNPFTAIG CAMTETGGGP DDLPSYPPKK - 2220 EVSEWSDGSW STTTTASSYV TGPPYPKIRG KDSTQSAPAK RPTKKKLGKS EFSCSMSYTW - 2280 TDVISFKTAS KVLSATRAIT SGFLKQRSLV YVTEPRDAEL RKQKVTINRQ PLFPPSYHKQ - 2340 VRLAKEKASK VVGVMWDYDE VAAHTPSKSA KSHITGLRGT DVRSGAARKA VLDLQKCVEA - 2400 GEIPSHYRQT VIVPKEEVFV KTPQKPTKKP PRLISYPHLE MRCVEKMYYG QVAPDVVKAV - 2460 MGDAYGFVDP RTRVKRLLSM WSPDAVGATC DTVCFDSTIT PEDIMVETDI YSAAKLSDQH - 2520 RAGIHTIARQ LYAGGPMIAY DGREIGYRRC RSSGVYTTSS SNSLTCWLKV NAAAEQAGMK - 2580 NPRFLICGDD CTVIWKSAGA DADKQAMRVF ASWMKVMGAP QDCVPQPKYS LEELTSCSSN - 2640 VTSGITKSGK PYYFLTRDPR IPLGRCSAEG LGYNPSAAWI GYLIHHYPCL WVSRVLAVHF - 2700 MEQMLFEDKL PETVTFDWYG KNYTVPVEDL PSIIAGVHGI EAFSVVRYTN AEILRVSQSL - 2760 TDMTMPPLRA WRKKARAVLA SAKRRGGAHA KLARFLLWHA TSRPLPDLDK TSVARYTTFN - 2820 YCDVYSPEGD VFVTPQRRLQ KFLVKYLAVI VFALGLIAVG LAIS
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Functional narrative |
Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Probably also regulates many host cellular functions such as antiviral state inhibition, cell transformation and apoptosis. Envelope glycoproteins E1 and E2 are involved in virus attachment to the host cell as well as in virus endocytosis and fusion with host membrane. P13 may function as a multimeric ion channel protein (viroporin). Protease NS2-3 is a cysteine protease responsible for the autocatalytic cleavage of NS2-NS3. NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B By similarity. NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction and likely RNA stable secondary structure in the template strand. Cleaves and inhibits the human antiviral protein MAVS. NS5A is a component of the replication complex involved in RNA-binding. NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication.
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Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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