| General information | | DisProt: | DP00674_C001 | | Name: | Core protein | | Synonym(s): | POLG_GBVB
cleavage product 1 of Genome polyprotein
| | First appeared in release: | Release 5.1 (05/28/2010) | | UniProt: | Q69422 | | UniGene: | | | SwissProt: | POLG_GBVB | | TrEMBL: | | | NCBI (GI): | 68565638 | | Source organism: | Hepatitis GB virus B (GBV-B) (GB virus B) | | Sequence length: | 156 | | Percent disordered: | 99% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MPVISTQTSP VPAPRTRKNK QTQASYPVSI KTSVERGQRA KRKVQRDARP RNYKIAGIHD - 60
GLQTLAQAAL PAHGWGRQDP RHKSRNLGIL LDYPLGWIGD VTTHTPLVGP LVAGAVVRPV - 120
CQIVRLLEDG VNWATGWFGV HLFVVCLLSL ACPCSG
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| Functional narrative |
Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Probably also regulates many host cellular functions such as antiviral state inhibition, cell transformation and apoptosis. Core protein is cleavage product 1 of Genome polyprotein, comprising aa residues 1-156 of the polyprotein.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 2 - 156 | | Length: | 155 | | Region sequence: |
PVISTQTSPVPAPRTRKNKQTQASYPVSIKTSVERGQRAKRKVQRDARPRNYKIAGIHDG
LQTLAQAALPAHGWGRQDPRHKSRNLGILLDYPLGWIGDVTTHTPLVGPLVAGAVVRPVC
QIVRLLEDGVNWATGWFGVHLFVVCLLSLACPCSG | | Modification type: | Native
| | PDB: | | | Structural/functional type: | | | Functional classes: | Chaperones
| | Functional subclasses: | | Detection methods:
- Circular dichroism (CD) spectroscopy, far-UV (293 K; pH: 7.4; 2-mercaptoethanol 5 mM; path-length (quartz cuvette (Hellma)) 0.02 cm; protein (sample) 20 uM; sodium phosphate (buffer) 20 mM)
| References:
- Ivanyi-Nagy R, Lavergne JP, Gabus C, Ficheux D, Darlix JL. "RNA chaperoning and intrinsic disorder in the core proteins of Flaviviridae." Nucleic Acids Res. 2008; 36(3): 712-725. PubMed: 18033802
| Comments:
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