10         20         30         40         50         60
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SDTKEEGATK KKTQKPDRLE RGKMKIVPKE SEKDSKTKPP DATIVVEGVK YQVRKKGKTK - 60
SKNTQDGLYH NKNKPQESRK KLEKALLAWA IIAIVLFQVT MG

The viral RNA of pestiviruses is expressed as a single polyprotein which undergoes post-translational proteolytic processing resulting in the production of at least eleven individual proteins. The N-terminal protease cleaves itself from the nascent polyprotein autocatalytically and thereby generates the N-terminus of the adjacent viral capsid protein C. BVDV is divided in two types: cytopathic and non-cytopathic. Both types of viruses can be found in animals suffering from mucosal disease, as a cytopathic BVDV can develop from a non-cytopathic virus within the infected animal by deletions, mutations or insertions. Both types express uncleaved NS2-3, but cytopathic strains also express NS3. The cytopathic NADL strain contains an insertion (Jiv 90) that potentiate the partial cleavage of NS2-3. Removal of this insertion in the NADL Jiv 90- strain results in a non-cytopathic strain in which NS2-3 remains uncleaved. (UniProt) Capsid protein C is cleavage product 2 of Genome polyprotein, comprising aa 169-270 of the polyprotein.