| General information | | DisProt: | DP00685 | | Name: | Viral macrophage inflammatory protein 2 | | Synonym(s): | VMI2_HHV8
Viral macrophage inflammatory protein II
vMIP-II
vMIP-1B
| | First appeared in release: | Release 5.5 (11/17/2010) | | UniProt: | Q98157 | | UniGene: | | | SwissProt: | VMI2_HHV8 | | TrEMBL: | | | NCBI (GI): | 8928443 | | Source organism: | Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus) | | Sequence length: | 94 | | Percent disordered: | 31% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MDTKGILLVA VLTALLCLQS GDTLGASWHR PDKCCLGYQK RPLPQVLLSS WYPTSQLCSK - 60
PGVIFLTKRG RQVCADKSKD WVKKLMQQLP VTAR
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| Functional narrative |
Blocks infection by several different human immunodeficiency virus type 1 (HIV-1) strains. This occurs because vMIP-II binds to a wide range of chemokine receptors. May form part of the response to host defenses contributing to virus-induced neoplasia and may have relevance to KSHV and HIV-I interactions. (UniProt).
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered - Extended | | Name: | N-terminal domain | | Location: | 21 - 44 | | Length: | 24 | | Region sequence: |
GDTLGASWHRPDKCCLGYQKRPLP | | Modification type: | Monomeric
Native
| | PDB: | 1VMP:A | | Structural/functional type: | Function arises from the disordered state
| | Functional classes: | Molecular recognition effectors
| | Functional subclasses: | Protein-protein binding
| Detection methods:
- Nuclear magnetic resonance (NMR) (298 K; pH: 5.4; )
| References:
- Liwang AC, Wang ZX, Sun Y, Peiper SC, Liwang PJ. "The solution structure of the anti-HIV chemokine vMIP-II." 1999; 8(11): 2270-80. PubMed: 10595530
| Comments:
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| Region 2 | | Type: | Disordered - Extended | | Name: | C-terminal region | | Location: | 90 - 94 | | Length: | 5 | | Region sequence: |
PVTAR | | Modification type: | Monomeric
Native
| | PDB: | 1VMP:A | | Structural/functional type: | Function arises from the disordered state
| | Functional classes: | Molecular recognition effectors
| | Functional subclasses: | Intraprotein interaction
| Detection methods:
- Nuclear magnetic resonance (NMR) (298 K; pH: 5.4; )
| References:
- Liwang AC, Wang ZX, Sun Y, Peiper SC, Liwang PJ. "The solution structure of the anti-HIV chemokine vMIP-II." 1999; 8(11): 2270-80. PubMed: 10595530
| Comments:
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| References |
- Liwang AC, Wang ZX, Sun Y, Peiper SC, Liwang PJ. "The solution structure of the anti-HIV chemokine vMIP-II." 1999; 8(11): 2270-80. PubMed: 10595530
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| Comments |
AV 02/16/2011 (PubMed: 10595530)
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