| General information | | DisProt: | DP00686 | | Name: | Glycoprotein G | | Synonym(s): | GLYCP_NIPAV
NiV glycoprotein
NiV-G
| | First appeared in release: | Release 5.1 (05/28/2010) | | UniProt: | Q9IH62 | | UniGene: | | | SwissProt: | GLYCP_NIPAV | | TrEMBL: | | | NCBI (GI): | 82036174 | | Source organism: | Nipah virus | | Sequence length: | 602 | | Percent disordered: | 4% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
| | | | | |
MPAENKKVRF ENTTSDKGKI PSKVIKSYYG TMDIKKINEG LLDSKILSAF NTVIALLGSI - 60
VIIVMNIMII QNYTRSTDNQ AVIKDALQGI QQQIKGLADK IGTEIGPKVS LIDTSSTITI - 120
PANIGLLGSK ISQSTASINE NVNEKCKFTL PPLKIHECNI SCPNPLPFRE YRPQTEGVSN - 180
LVGLPNNICL QKTSNQILKP KLISYTLPVV GQSGTCITDP LLAMDEGYFA YSHLERIGSC - 240
SRGVSKQRII GVGEVLDRGD EVPSLFMTNV WTPPNPNTVY HCSAVYNNEF YYVLCAVSTV - 300
GDPILNSTYW SGSLMMTRLA VKPKSNGGGY NQHQLALRSI EKGRYDKVMP YGPSGIKQGD - 360
TLYFPAVGFL VRTEFKYNDS NCPITKCQYS KPENCRLSMG IRPNSHYILR SGLLKYNLSD - 420
GENPKVVFIE ISDQRLSIGS PSKIYDSLGQ PVFYQASFSW DTMIKFGDVL TVNPLVVNWR - 480
NNTVISRPGQ SQCPRFNTCP EICWEGVYND AFLIDRINWI SAGVFLDSNQ TAENPVFTVF - 540
KDNEILYRAQ LASEDTNAQK TITNCFLLKN KIWCISLVEI YDTGDNVIRP KLFAVKIPEQ - 600
CT
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| Functional narrative |
Oligomeric type II transmembrane glycoprotein that interacts with host cell surface glycoproteins ephrinB2/EFNB2 and/or ephrin B3/EFNB3 to provide virion attachment to a target cell.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 236 - 245 | | Length: | 10 | | Region sequence: |
RIGSCSRGVS | | Modification type: | Fragment
Monomeric
Native
| | PDB: | 2VWD:A, 2VWD:B | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Unknown
| | Functional subclasses: | Unknown
| Detection methods:
- X-ray crystallography (277 K; gamma-butylactone (18%); Lithium chloride (0.1 M); MES (0.1 M, pH 6.0); PEG 6000 (20%))
- High relative B-factor
| References:
- Bowden TA, Crispin M, Harvey DJ, Aricescu AR, Grimes JM, Jones EY, Stuart DI. "Crystal structure and carbohydrate analysis of Nipah virus attachment glycoprotein: a template for antiviral and vaccine design." J Virol. 2008; 82(23): 11628-36. PubMed: 18815311
| Comments:NiV-G residues 183 - 602 were used in this study.
|
| Region 2 | | Type: | Disordered | | Name: | | | Location: | 579 - 590 | | Length: | 12 | | Region sequence: |
EIYDTGDNVIRP | | Modification type: | Fragment
Monomeric
Native
| | PDB: | 2VWD:A, 2VWD:B | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Molecular assembly
| | Functional subclasses: | Protein-protein binding
| Detection methods:
- X-ray crystallography (277 K; Gamma-butylactone (18%); Lithium chloride (0.1 M); MES (0.1 M, pH 6.0); PEG 6000 (20%))
- High relative B-factor
| References:
- Bowden TA, Crispin M, Harvey DJ, Aricescu AR, Grimes JM, Jones EY, Stuart DI. "Crystal structure and carbohydrate analysis of Nipah virus attachment glycoprotein: a template for antiviral and vaccine design." J Virol. 2008; 82(23): 11628-36. PubMed: 18815311
| Comments:NiV-G residues 183 - 602 were used in this study.
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