General information | DisProt: | DP00688 | Name: | 2MDa_1 protein | Synonym(s): | Q8ISF7_CAEEL
TTN-1
Ce titin
W05H8.8c (WormBase)
| First appeared in release: | Release 5.1 (05/28/2010) | UniProt: | Q8ISF7 | UniGene: | | SwissProt: | Q8ISF7_CAEEL | TrEMBL: | | NCBI (GI): | | Source organism: | Caenorhabditis elegans | Sequence length: | 18534 | Percent disordered: | 22% | Homologues: | |
Native sequence |
10 20 30 40 50 60 | | | | | | MEGNEKKGGG LPPTQQRHLN IDTTVGGSIS QPVSPSMSYS TDRETVMRSA SGHATVAETH - 60 LIRSIGSQSQ SYTEEHWSSE ITSFVALAPP KFIQVIKAYR VHSTDTISLV VEVASDPPAI - 120 FEWFYNEKSV LQDRDRFQVG HGINISRLKV SRPEQGVYKC VTRNPAGVST SYGYITVNAD - 180 REHLSSSKED MRLQRQHSVT YHQAPRFLTQ VPNLFVTAGS NVIIDVEVDA NPPARFSWFV - 240 NGKEYRDSIH GVEMFSPDVN RSVVRFSIPV AGEYKVVASN VHGSAMSCGH VDIQKVIELE - 300 ESTLTTSTTA FDPMTTSMRA LGNNGRNSRQ AVNMFELNYT QRSSSVPRGV RHLESHIEVS - 360 NMTGEEKKTQ QQTRTDAASI VESRFHPQPP KPPRAGTSRR FLPEPPKFVT TLPSVITVNA - 420 EEKLVLSVDV QAIPAAEFAW HVNGFEVKKS QSVVLLDEHN KSTLVLHPPV KQGKYKVTAR - 480 NDVGSDSVTT QVTRIGEVKD GAGSEPPDIV ESAVTVTCSH EEDVGSHSSL QTVRRIQEMQ - 540 EEDEVDPIKP FIEATSPKVK ESVEHPFANI LNPKKREERL SPSGKGKHLL FAPRITAHPS - 600 ESVFKILDGS PLKLRVMASS LPPATFLWML NNFELRSNQN VTIRNDEENS SEIEFQKAPN - 660 GNVTVSAKNH LGEDRWTGKV ILQYESPPPG QKITTIEKVT ESWTLEEAVI TQVVPTAADP - 720 GDRIVIIVRF DENKTSNCQF NWTINGVNIE KLEENLVAVE STEFESSLIV EKLEEQLCGE - 780 VVCVVKNQHG EVFSSSAHLR IRDDDSSFEI VPPNLPEECA PKIVEPLHSA SFLDGQAMSL - 840 RCKITANPSA AVVWSKDDVN VEDWVLNKDV TTTVLDGGVC ELLNPECFAE DAGLYKCTAT - 900 NPHGTAETAA FINVEGAEYI KDHEEAEISE SVLTDDVHII LPPKFIETLT AETDNFQQLG - 960 YVRMVATVRS VAPITVSWQK DGMDIYENEK YEVMQFADGA QILTIRAPTN LDSGVYTCTA - 1020 ESEHGVSNSS CQVELTISAE SSPESFEKVE ITPPEEVKET GIDDDIEVIL KEEVSGTAQI - 1080 EKREEEFKLL VKVADQVAST LVANVFLEAV HEAVKKIVET EDEEEDNQIE ATQEPRFETS - 1140 TDEYHVKENG TIKMAATISG HPTPFLEWYF GEEKLQVSQN VSMYYEAGTS AIILKNVQKR - 1200 QGGNYFLRAH NCHGESILPM KLTVDPIEAV THVLETSIPK VVVEQDAKEE EVRRAAEIIS - 1260 EQFAQLWVQD AQTEAVSAQA HQTPVVAEQA SEEPTLPEVV AALQEQKPSV EKAPQPQFEV - 1320 LETEDQDVVE QMQKQLPPVQ KSMSVQEEKA SSQRTPSPMN YEDKVKTIQS NLLRVNSHEA - 1380 MEPIEATNLL LNTALQLKNE HVCDETTTVI VTQQPQKYDQ LVTVVESNIE YHALRLSTSS - 1440 SSPLKFIDLE TIIQKPSTSC ESIDRMFVEK SKRTANAQHR IVVLQGMSNT FHNAITWSLK - 1500 KVKKLVGDAE AKAYADVEVV KQDETNEQVM TIIDNDTIVP QLLQVAAAAN KLKLENVSVA - 1560 LIKEGDRAHQ ELVIEYESSI DEPMFEPVHN TSHLTFHQQQ PTGPDQHVWS RRSKFEEDEA - 1620 HVVAVFVEVD ANCPDQSVEI VATVNAAYEG DNRQGIEDEP FTEVSQSLAT ESSAAPQAPK - 1680 FLRKLVNCFG RIGEPVQLKC LIAGMPQPEI EWTVDGDPIV PNDEYSIVYE DGVCILRIES - 1740 TLIEDEGEYC CTASNVAGTT FSKCYLKLSE ADDDAVDLLR QLSEIKIIDP TLSTGYPMSM - 1800 ISDEENTSHQ LLSNVLLTDK EVPITATYNE DLSRAESFRR FFESAETTVK VTELYQGESV - 1860 EAQFQQPEKR EQVSTSNTDV MFVNQKVDVM ESTVSTVGNA VRQSVSSSTN SWDYMFNDPF - 1920 PESQEINVIE NELYEPRVPL LPQKLSYKGQ EIFANTNTVE RNSKAGAKAK GEVENLKKCV - 1980 ETLLLFDAEM DMKDIKESSP KKEIISKKDQ QSLDDQIKVT QQILKDVERD LNKMERTSPG - 2040 KSLSPNKRTF APKDVEDIEA AIFSISDQLA DRQSSEEALR EALQEMILSN SSPMKELSRN - 2100 NETSKPEVLK SEIQKIPEVE TKISEVYPIV KLKQAISAIE NSLLEDTEVT EIMKRKGSDK - 2160 DKRKATRIKR VPSAHSARIT PITSNLRDRL NQLHQLTVSE DSGSLKQNEE AKEIQELFVK - 2220 IEKEINTIAE LCKEKMTKKG ADTVTHVLNS VLQHVASIIN VILVAQDHQP IEVHAETTKT - 2280 AEVSVWYSFD VHPESEDIIG IVDEEPTNRR PSSTPRGSTR SSNLTTSQDS QATTKMTVSS - 2340 EDTIEAPIAP PRKGRSLSRD AERLLEIQPR APPRRSRQSG DTLSPEPTPV LTLVKSDETP - 2400 APVRPPRSRS RHSGDELAET SPEAQPIRPP RSHSRHSGDE LEEVQPVRPP RSKSKTADAN - 2460 CLQIESMDES QYSLSCIHIQ KTNFAFTNST HETSNASVVV DLRNMAQLEC TVQSLDDLAS - 2520 IQMLCEESDY PSDTDRSLLL AGTVRYFNRA SPSLHEVSPS LNMESVSMDL KPETEPEEIV - 2580 QDVYVNVELH SVPSLSSLVE VNPNTLMQTL ASEKSSLKAA EEDEKEGEEE GEEEVTADVS - 2640 FIGRSVLSTE TLDVVLEEKD MSQMNSTLPL DYERAFSSNT IRETDILSDE SITVDSSYHK - 2700 SPEPTVDFAR SQVKSEEVTE NFSLIHKPAR RRVTGIVVNS LIYTIAANIA EDNTFDVDVV - 2760 QEPQRYNISI KVIEDIVDFT SLTIMSDCED DPPADVLVLK QDTSKLQALS YDDISVATTR - 2820 TGITVSIVAR SLNDGIYASL EEIAWGEVEM TVPDIMQMST EEKSSLQFNV TVSESNLEEA - 2880 KSLKSQVSFR SSQNSVSEMD NTISSTATIS IPSYVVKLES TATITCELNN YLPKNCTIDW - 2940 YCGKTKIIID HEQFDRISHD LLEVLIIRSV EAINGNLYSL KINEDLFPVA YLIVENTNLT - 3000 TSANILTRPE TQFVMEGQPT VITVELDDPN VIVNWLKDRR PLHENERIRL ETDGQGNHRV - 3060 IIPNTCVGDQ GTYLALTSSE SVAITLVVEE RIEEKEVMVI ASGTESEEDD VQEYLVPPGS - 3120 TATIACELEE CELKRSIRWL RDGKDIRFEQ GKTEHVQNGL KHYLVVHDAT SLDSGLYKTE - 3180 RSEEQCEETI IPRGVVATIQ CQTSEPQESI QWSKDGNIIP SDISRFEFRS LDNNQSHEMV - 3240 ISNISWSDAG VYSVLINGKS SFVSKIVVVE SELITQSVEE EPEAEPEIDV SLHIVESEQI - 3300 IELNVPQSPK LGASHETLVP IGQDDIEVID KQEAAPVVES IEETSSIGSE EFEIIEKFTE - 3360 EEVPKVAEPS EPTQADVPKI AAPLEQSQIQ QEVPTVAAPS EPTQADVPKE AAPSEPSQAD - 3420 VPKVAAPLEQ TQIQQEVPMV AAPLEPTQAD VPKVAAPLEQ SQIQQEVPTV AAPSEPTQAD - 3480 VPKEAAPSEP SQADVPKVAA PLEQTQIQQE VPMVAAPLEP IQEEVPKEAA PSEPTQEDVP - 3540 KGAAPLEPTQ EDVPKEAAPS GPTQEDVPKE EAPSEPTQED VPKEAAPSEP TQENVPKEAA - 3600 PSEPTKDVPK EAAPSEPIQE EVPKEATLSE PTQEQSEVSK RSEPVEPTQI QQAASEEETP - 3660 LEETNETVVQ TNEDVKEAEV PENAEAQKVV DSSDLQVAAS EIAHLAIDEA VLETSNQPSQ - 3720 FDSLQEQKPS VVHENEHVRS VCVDLTFSRD SEQIVSDVIV AEVGYDEDEC STIADTITSL - 3780 SSSPLYTAPV FTERLPSSAC FANSKLTLEV MFSGVPQPTI SWLIDDHELV SDGERISIKC - 3840 ENGVSAIRFF NVDRNAGGFL KCRATNCAGQ VETSCEIVAA DEISVISDSS ITSSTRPHFV - 3900 VPLPERVTHT VNDHITIKCK FSGQPLPAAM WEKDGVLLDL QKYQVTTEDG TSILKIESAS - 3960 LDDKAVYTCT IANEAGCEST SCTIDVVDDH LGLQQTGLHV MCERDQNDVE LDILVQSPNH - 4020 LGVTFNFPPV NRTLARQPPY FLLPLSDKVV IDEKCTLKCV VMGIPLVIVK WIVDGVVVTE - 4080 DDNHEIHFED GIALLRMKNI KKDKSVVQCE AINCKGKVTT SCVLTKCGVE ESEAGDLQKP - 4140 SFVLSLKDTC TTTDHATLKC IVVGTPLPDV SCSFNGVTDN SKIRSEDGIV LIQVNDVTEE - 4200 GIVVECTISN ETGSSTSNCV VKIIKQEEKN YQRPIIVFNQ AGSVNNEREL SVKVGVIASP - 4260 EPTLFWKHNG KSIEEGGDYY LIFEDGIGIL KVFNIQDGSH EFTCIAKNEY GQTTVEIPVE - 4320 IGLKTENKLT LVKTLNDIAV VDDIVQLKIV AEGDLPIEFK WFEDGQILED DSSHKITVDK - 4380 CISTLQLKLE ETGTRIITCE VSNSSSKVNA SCNVERVHNT VSDFVMTNDN STRFLAVGRK - 4440 CTRERNNTIL KAVVVARENI GDICEIDGEK IPDAYIEGNS LSIKVDTLSK KLSNVSFKVS - 4500 ASEGKVFETR KIEIAQEDTD EENFEINYSL RIDEQSGNTT YTFENSELYQ GNQSRELDNT - 4560 ERNFTVNKEK DESKKPSEVQ PAEIVEQKDV PVQETSAPTV EKLAPVESKE TPEVQAAEIV - 4620 EQKDVPVPET RAPTVEPTVE KHTPVDSKET SEVEPAEIVE QKDVPVPETS APTVEPTVEK - 4680 HTPVESKEKS EVQPAEIVEQ KDVTCEEEIK ELLTEVEVEL FFSQAEVFSG LELDLLMECS - 4740 EYVTTSIQKG STAAPAQEPT VEKLAPVESK ETSEVEPAEI VEQKDVPVPE TSAPSVEPTV - 4800 EKLAPVESKE TSEVQQAEIV EQKDVPVPET SAPSVEPTVE KLAPAESKET SEVQPAEIVE - 4860 QKDVTCEEEI KELLTEVEVE LFFSQAEVFS GLELDLLMEC SEYVTTSIQK GSTAAPAQEP - 4920 TVEKLAPVES KETSEVQQAE IIEQKDVPVP ETSAPTVEPT VEKLKPVESK ETSEVQQVEI - 4980 IEQKDVPVPE TSAPTVEPTV EKLAPVESKE TSEVQQAEII EQKDVPVPET SAPTVEPTVE - 5040 KLKPVESKET SEVQQVEIIE QKDVPVPETS APTVEPTVEK LAPVESKETS EVQQAEIIEQ - 5100 KDVPVPETSA PTVEPTVEKL KPVESKETSE VQQVEIIEQK DVPVPETSAP TVEPTVEKHA - 5160 PVESKETSEV QPAEIVEQKV VPVPETSAPT VEPTVEKLAP VESKETPEVQ PAEILEQKDV - 5220 TCEEEIKELL TEVEVELFFS KAEVFSGLEL DLLMECSEYV TTSIQKGSTA APAQEPTVEK - 5280 LAPVESKETS EVEPAEIVEQ KDVPVPETSA PTVEPTVEKL KSVESKETSE VQQAEIIEQK - 5340 DVPVPETSAP TVEPTVEKLA PVDSKETSEV EPAEIVEQKD VTCEEEIKEL LTEVEVELLF - 5400 SQAEVFSGLE LDLLMECSEY VTTSIQKGST AAPAQEPTVE KLAPVESKET SEVEPAEIVE - 5460 QKDVPVPETS APTVEPTVEK LKSVESKETS EVQQAEIIEQ KDVPVPETSA PTVEPTVEKH - 5520 APVESKETSE VQPAEIVEQK VVPVPETSAP TVEPTVEKLA PVESKETSEV EPAEIVEQKD - 5580 VPVPETSAPT VEPTVEKLAP VESKETSEVE PAEIVEQKDV PVPETSAPTV EPTIEKLAPV - 5640 ESKETSEVEP AEIVEQKDVS VPETSAPTVE PTIEKLAPVE SKETSEVEPA EIVEQKDVSV - 5700 PETSAPTVEP TVEKLAPVES KETSEVEPAE IVEQKDVPVP ETSAPTVEPT VEKLAPVESK - 5760 ETSEVQPAEI VEHKDVQVPE TSSPTVEPTV EKLAPVESKE TSEVEPAEIV EQKDVPVPET - 5820 SAPTVEPTVE KLAPVESKET SEVEPAEIVE QKDVPVPETS APTVEPTVEK LAPVESKETS - 5880 EVQPAEIVEQ KDVSVPETSA PTVEPTVEKL APVESKETSE VQPAEIVEQK DVPVPETSAP - 5940 TVEPTVEKLA PVESKETSEV QPAEIVEHKD VQVPETSSPT VEPTVEKLAP VESKETSEVE - 6000 PAEIVEQKDV PVPETSAPTV EPTVEKLAPV ESKETSEVQP AEIVEHKDVQ VPETSAPTVE - 6060 PTIEKLAPVE SKETSEVEPA EIVEQKDVSV PETSAPTVEP TIEKLAPVES KETSEVQPAE - 6120 IVEHKDVQVP ETSSPTVEPT VEKLAPVESK ETSEVQPAEI VEQKDVTCEE EIKELLTEVE - 6180 VELFFSQAEV FSGLELDLLM ECSEYVTTSI QKGSTAAPAH EPTVEKLAPV ESKETSEVEP - 6240 AEIVEQKDVP VPETSAPTVE PTVEKLAPVE SKETSEVEPA EIVEQKDLPV PETSAPTVEP - 6300 TVEKLAPVES KKTSEVEPAE IVEQKDVPVP ETSAPTVEPT VEKLAPVESK ETSEVEPAEI - 6360 VEQKDVPVPE TSAPTVEPTV EKLAPVESKE TSEVEPAEIV EQKDVPVPET SAPTVEPTIE - 6420 KLAPVESKET SEVEPAEIVE QKDVSVPETS APTVEPTIEK LAPVESKETS EVEPAEIVEQ - 6480 KDVSVPETSA PTVEPTVEKL APVESKETSE VEPAEIVEQK DVPVPETSAP TVEPTVEKLA - 6540 PVESKETSEV QPAEIVEHKD VQVPETSSPT VEPTVEKLAP VESKETSEVE PAEIVEQKDV - 6600 PVPETSAPTV EPTVEKLAPV ESKETSEVEP AEIVEQKDVP VPETSAPTVE PTVEKLAPVE - 6660 SKETSEVQPA EIVEHKDVQV PETTATTFEP TKEKLAPVDS KETSEVQTAE IVEQKDVPVP - 6720 ETSATTVEPT KEKLAPGESK ETSEVQQAAI VEQKDVAVPE TSATTVEPTK EKLAPVESKE - 6780 TSEIQTAEIV EQKDVPVPET STSYVEPTKE KLAPGESKET SEVQQAAIVE QKDVPVPETS - 6840 ATTVEPTKEK LAPVESKETS EIQQAAVVEQ KDVPVPETSA TTVEPTKEKL APVESKETSE - 6900 VQQAAIVEQK DVPVPEANAP TFEPTVEKLA PVESKETSEV QQAAIVEQKD VPVPEANAPT - 6960 VEPTVEKLAP VESKETSVES KETQADAKLK KEKDDKHKQE ADAKLQKEND DKLKQEADAK - 7020 LKKENDDKLK QEADAKLKKE NDDKLKQEAD AKLKKENDDK LKQEAAAKLK KENDDKLKQE - 7080 ADAKLKKEND DKLKQEADAK LQKENDDKLK QEADAKLQKE NDDKLKQEAD AKLQKENDDK - 7140 LKQEADAKLQ KENDDKLKQE ADAKLQKEND DKLKQEADAK LKKENDDKLK QEADAKLKKE - 7200 KHDKLKQEAD AKLQKENDDK LKQEADAKLQ KENDDKLKQE ADAKLQKEKD DKLKQEADAK - 7260 LKKEKDDKLK QDADAKLQKE KDDKLKQEAD AKLKKEKDDK LKHEADAKLQ KEKDDKLKQE - 7320 ADAKLKKEKD DRLKKDADAK LQKEKDDKLK QEADAKLKKE KDDKLKHEAD AKLQKEKDDK - 7380 LKQEADAKLK KEKDDKLKQE ADAKLQKEKD DKLKQEADAK LKKEKDDKLK QEADAKLQKE - 7440 KDDKLKQEAD AKLKKEKDDK LKQEADAKLQ KEKDDKLKQE ADAKLKKEKD DKLKQEADAK - 7500 LKKEKDDKLK QDADAKLQKE KDDKLKQEAD AKLKKEKDDK LKHEADAKLK KEKDDKLKQE - 7560 ADAKLKKEKD DKLKQDADAK LKKEKDDKLK HEADAKLQKE KDDNFKQEAN AKLQKEKDDK - 7620 LKQEKDDNFK QEANAKLQKE KDDKLKQEKD DKLKQEADAK LKKEKDDKLK QEADAKLKKE - 7680 KDDKLKQEAD AKLKKDKDDK LKQEADAKLK KEKDDKLKQE ADAKLKKDKD DKLKQEADAK - 7740 LKKDKDDKLK QEADAKLKKE KDDKLKQEKN DKLKQEADAK LKKEKDDKLK QEADAKLKKE - 7800 KDDKLKQETD AKLKKDKDDK LKQEADAKLK KDKDDKLKQE ADAKLKKDKD DKLKQEADGK - 7860 LKKEKDNKLK QEADGKLKKE KDNKLKQEAD AKLKKEKDDK LKQEADAKLK KEKDDKLKQE - 7920 ADAKLKKDKD DKLKQEADAK LKKEKDDKLK QEADAKLKKD KDDKLKQEAN AKLQKEKDDK - 7980 LKQEADAKLQ KEKDDKLKQE ADAKLKKEKD DKLKQEADAK LQKEKDDKLK QEADAKLKKE - 8040 KDDKLKQEAD AKLQKEKDDN FKQEANAKLQ KEKDDKLKQE KDDKLKQEAD AKLKKEKDDK - 8100 LKQEADAKLK KDKDDKLKQE ADAKLKKEKD DKLKQEADAK LKKEKDDKLK QEADAKLKKD - 8160 KDDKLKQEAD AKLKKDKDDK LKQEADAKLK KEKDDKLKQE TDAKLKKDKD DKLKQEADAK - 8220 LKKEKDDKLK QEADAKLKKE KDDKLKQEAD AKLKKEKDDK LKQEADAKLK KDKDDKLKQE - 8280 ADAKLKKDKD DKLKQEADGK LKKEKDNKLK QEADGKLKKE KDNKLKQEAD AKLKKEKDDK - 8340 LKQEADAKLK KDKDDKLKQE ADAKLKKEKD DKLKQEADAK LKKEKDDKLK QEADAKLKKD - 8400 KDDKLKQEAD AKLKKDKDDK LKQEADAKLK KEKDDKLKQE ADAKLKKDKD DKLKQEADAK - 8460 LKKDKDDKLK QEADAKLKKE KGDKLKLEDQ TNQSRIFEET SIEVTSLLKC KQQAIIVSKS - 8520 FALCERVVLN AEEPFTLEVF CNAVFVKQRT DKIGIGIIFE RSGASKKDES RPDRLDDNCV - 8580 LTDVTDGLSI LSPPPKAKKH LKKKKKHHKK EKIAVKETEQ DEKTVSHLKP EISGMERKRS - 8640 NSGSSDIFVD VDIEAGEESI HTDALVDLNF YDYDQMELSI FEDYDSDDDS ASIDCDVSLS - 8700 NVAADDGIDV FPSDGDTQEV EQKVTLPKKH QSDEDVISKE EENLETSVSY GSIEETVSFT - 8760 IGTGQSIIEH PKSHAVGQMN SEVIIKCKTS QPISDAKWFC NGMVLLPDEQ VNMTVTGCEA - 8820 VLRLVKFLPQ NKGNYHVLID GSIGSQPAIL SGPVPPVILN KLTKPITHQA GKSFTYKFNF - 8880 MGAPAPRLRV LSNGEPVSFD VKYEIYDNIA SLYIPKMSKR DGGEYTVVLE NKYGKDESDL - 8940 HITMVDTPLK PRKAQLVALT DTSATFKWLP PHTGESDILH YIVMRRSTES RRWRNIGHVQ - 9000 EKTFTAIELV PNEFYAFRIV AVNGFGEGAP SEIIEVNTLD YDQEESFDFA GEEELKLDDV - 9060 QVNNEVVTEI TIEESEVTIE EHRKLKKKSK KSKKTTDEPE LDSEIALEVS SDITSSLEIT - 9120 TESTIPDTAP ESQETLNVEI AVTETTVQKI TNPSDESAKK DVNEDTAVSS IVKKDDKDVN - 9180 KKSLPESGLT TKKEIQGKPE KKIMKKKTEK ADSSISETSE TLTKDLTQTK QSEPEPAKRT - 9240 TETSVQDEVK RKTETTSKSK QTTEEHPQPG GKSDSSISST SDASEVKQVQ QSESEAQKVT - 9300 EKPETAKLES KSKMTEDTTK ESDNKETVDE KPKKKVLKKK TEKSDSTISE TSETSAVESA - 9360 GPSESETQNV AAVDKEKKQK ETDEKQKLEA EIAGKKSTEQ KSKLEAEAKL KRAAEEDAAK - 9420 KQKEKTEAAS KKAAAEKLEL EKQAQINKAA EADAVKKQNE LDEQNKLEAT KKLAAEKLKL - 9480 EEQSAAKSKQ AAEEQAKLDA QTKAKAAEKQ TGLEKDEKSN KDSGSNETVE EKPKKKVLKK - 9540 KTEKSDSSIS QKSDTSKTVA ESAGSSESET QKVADATSKQ KETDKKQKLE AEITAKKSAD - 9600 EKSKLETESK LIKAAEDAAK KQKEKEDKLK LEADVASKKA AAEKLELEKQ AQIKKAAEAD - 9660 AVKKQKELAE KQKLESEAAT KKAAAEKLKL EEQAQINKAA EADAVKKQKE LDEKNKLEAN - 9720 KKSAAEKLKL EEESAAKSKQ TVEEQAKLDA QTKEKTAEKQ TGLEKDDKST KDSESKETVD - 9780 EKPKKKVLKK KTEKSDSSIS QKSVTSKTVV ESGGPSESET QKVADAARKQ KETDEKQKLE - 9840 AEITAKKSAD EKSKLEAESK LKKAAEVEAA KKQKEKDEQL KLDTEAASKK AAAEKLELEK - 9900 QAQIKKAAEA DAVKKEKELA EKQKLESEAA TKKAAAEKLK LEEQKKKDAE TASIEKQKEQ - 9960 EKLAQEQSKL EVDAKKSAEK QKLESETKSK KTEEAPKESV DEKPKKKVLK KKTEKSDSSI - 10020 SQKSDTAKTV AESAGQSDSE TQKVSEADKA HKQKESDEKQ KLESEIAAKK SAEQKSKLET - 10080 EAKTKKVIED ESAKKQKEQE DKKKGDDSAK KQKDQKEKQK LESEATSKKP TSEKQKDEKT - 10140 PQEKAKSENE TVMTTEPQQL EVKSEPKKSD KTETVEKEVA SSTEKSDDSK TKEPKEKKKI - 10200 IKKKKDTTKP QEASKELSSD ESRIDLESDI SLSLDTVTES DDLSTASTIK LQKESDESGI - 10260 DSRMGQTSEA EDSPFISQPV SATVTEMAGE AKFTVKFSRK PIYVKWMRDD REIRVAYGKA - 10320 SVETTDDSSV LVIKNIDGKD VGNIYAVFDS EYRSAMARLD LRVPCKITLE SSSNAPEIVA - 10380 GKNLDLSFKI SGYPLPTNIE LLHNNENLRT RSDVTDFDDS ISIRMKRLKL EDSGEIKIIG - 10440 KNDSSEDQLR IPINVIEVTS KPTSLQVTST ERETVTLTWS LPTELNGSNV NEYLVERKTV - 10500 DGGRWRHACT VTDSRAVVDG LFSGTEYVFR VVAVNGAGQS APSDTIEATT QAEEEIDETV - 10560 PTSPVEKVKE PVSKKPENTK ESEGHKKRDR KESEDHDENN LGKSGKDEFA TSGESGTSNQ - 10620 NEESAQLNTS FTSTEQHGQT EKQVRKGTRK SLTRSLNIRE SDIDADVVEV EYDEQGDDIP - 10680 SDPTTSGTYA FDKIEEEPAR TSGEMAMAEK DSDAMEVRGL NKKLSKKGGK EGTSTEKSSS - 10740 KTKKQEKSAL SVQEMNKSLK KKGEKGEAET AASDFIENAD QTGMSIQDLN KSMKKKVESG - 10800 EATGQINDAS NNKDADELSI QDSQQSLKKK SENESVTGEQ LDKSQEVEDD KMTIQSLKKS - 10860 IKKKPESREV SGGKSEKSKE KESDEMSIQQ LNKSVKKKPE NEAVTQGKSG KSQEQESDKM - 10920 SIQALNKSMK KKDGVDGVEG NINIGRSDGD QLSVNDIDAE LSTSEQVENA SQNLGATADS - 10980 DGDSLSLQTL KKRISKKGIH GEAESKLGEK QSGSDSFTLQ DLYEELKAKE DAVEAGAETS - 11040 NADQSAEKTS LEVRDMKKKM KKKQVSGTAE NLIGESNRDE TSMEIRDLNT QHSNQTGEDE - 11100 SSTFNFGQKD QEQYSMVMKD VSKKLARQNA EEIQSGKLIP TTNEEKTGLA LTGKNKNLKK - 11160 GEENEKTKFE AKHLGSSSAS DSLAESTLRS KKTKKGEVEK SELSIDMKNQ DKTTLATTLL - 11220 EDDLAKTTSA EESEAEHLVA LQNKEKTSLA MRRKRVSFDS STKSESIEDV IPDKNRDSDK - 11280 MSITGIKKKM SQKSESAEAQ KNESPEVKEI SSFEEKTLKS KKKSKADRNQ GTEANLGDKT - 11340 IDKDYLSVTD KNQSLEKSEA SGQAEKSIKA PNKSKVTTSF ADESLTSELD RLMADEEMAE - 11400 MMFAEEEKAA DLLNVMNKNK GLNKSEQEES QEISLKSQSK VKDSDSLSST DKKIGLKKSD - 11460 KDQKLGTSKI FGSKDQESVG YEEKTSNFSK QRRGVSDLGS DAMTDQKNVQ ESQYAEISAD - 11520 DHMSKTGADG EISATRTIVD GSDAAQGSEY AEISKKRKFK RAEQIGEAET SLCDSRENTH - 11580 DSLSISDVNP ELRRSNVEIS AFGQIDLTAE EVTSLTDINK DAQLTKKQDE NDAKKSVSKN - 11640 LKAGAKKDSD TLSITSKKDK FGKRQDSREA SATVEQQGEE KVTKNLKGSR GKKEKLGDAG - 11700 IDVNFENQEE FASTTGDIES IVSEKGHDTY SEKTVKSSKK KSPQTAGAEY GGSESLNASS - 11760 ALSTTDVDAQ LKNQEKDGVA ESSIGKSNQK DSYSEQELNV NKKKKQAVGA AMNQGSGSTK - 11820 ESDNLAVASV ESNLAKDSAN QEASLHGLVD NDATSLSQLD SEHRLKKRDD ELSAHTKLGK - 11880 HTQSENIALT ETDDSLVKGD SEESAELNIK QQGETAEDKY VESRKKTTLK KKPEQKQVTD - 11940 TLSAVDGRHD TTSLSVADSG ISFDKSMENE LAGSGDGTAS ASVSAKVRGA DGNAKTNLIS - 12000 SFEKPGQESK TSKTLSGKQK KQEKSSFAEK NAGFDLSMGE GKNDESVESS LQKNRDADSL - 12060 ALQGTDLAFS KPSDSSANAH LDMPQRELTL RICQAETVDW SDDSEVEEGT RTSAPGEVKK - 12120 KKKFIISAIS QDGEFSDAES ITFDENGVRV EKRRRKKRDP KEYMGAGELA MRIPAFAKKM - 12180 QYIGCIEGDV VVFTIKVVSD DVPLIRMYRN DFPVANFDKM AFEGFTKGSE HSFNVTINDI - 12240 RKLDGGKLVF EAKNDYGVDK CTILLDVRDS GSFIEDYSEI HRSAEIQNSV GDVQVKEGET - 12300 AKLTGRVDGF PLPELIWIKN GKEIDMMVPS TKYQLDYHSD GEFEARIANC TFEDDDDYSL - 12360 LVENLAGVDS CNFQVFVDCN EYPDDEHFNR RRRLQRGRRV MEASSDSELD DAKKRKKRRI - 12420 KRVVERRNPN APRLTQLIPP RFDKILSDHD AIEGENVVMM VETLGEPEPQ VRFYRDGKLI - 12480 DDGSGDRMEV RHEDEMRKHW LILKDICKDE EAEYACQAIN VAGEAWCFSD VVVHMSEESR - 12540 DDDKSVDEVD DSTVLEEKKD DGDDKSKPKT KKKIIKKKET PESEQVTAAE PEQQKISEVD - 12600 VQSVAETEVG AKKKPDAEKP TDLSKAKKDS KSKKSDEPEA STEEKSTTEK PTNDKTSKKS - 12660 AEKKTVKPKK EVTGKPLEAK KPVEDKKDAS QPSSSKESSP PTDGKKKKQI PKALFIPDEI - 12720 SSRFGDPSTM HSETNITTTI RGREGSADAK TPLVEPLSAS VSMKVESAKE KAEFSFKRRS - 12780 ETPDDKSRKK EGLPPAKKSE KKDEVTAEKQ STEALIESKK KEVDESKISE QQPSDKNKSE - 12840 VVGVPEKAAG PETKKDVSEI EEVPKKKTIK KKTEKSDSSI SQKSNVLKPA DDDKSKSDDV - 12900 TDKSKKTTED QTKVATDSKL EKAADTTKQI ETETVVDDKS KKKVLKKKTE KSDSFISQKS - 12960 ETPPVVEPTK PAESEAQKIA EVNKAKKQKE VDDNLKREAE VAAKKIADEK LKIEAEANIK - 13020 KTAEVEAAKK QKEKDEQLKL ETEVVSKKSA AEKLELEKQA QIKKAAEADA VKKQKELNEK - 13080 NKLEAAKKSA ADKLKLEEES AAKSKKVSEE SVKFGEEKKT KAGEKTVQVE SEPTSKKTID - 13140 TKDVGATEPA DETPKKKIIK KKTEKSDSSI SQKSATDSEK VSKQKEQDEP TKPAVSETQM - 13200 VTEADKSKKQ KETDEKLKLD AEIAAKTKQE ADEKSKLDAQ EKIKKVSEDD AARKEKELND - 13260 KLKLESEIAT KKASADKLKL EEQAQAKKAA EVEAAKKQKE KDEQLKLDTE AASKKAAAEK - 13320 LELEKQAQIK KAAGADAVKK QKELDEKNKL EANKKSAAGK LKIEEESAAK SKQTVEEQAK - 13380 LDAQTKAKTA EKQTKLEKDE KSTKESESKE TVDEKPKKKV LKKKTEKSDS SISQKSETSK - 13440 TVVESAGPSE SETQKVADAA RKQKETDEKQ KLEAEITAKK SADEKSKLEA ESKLKKAAEV - 13500 EAAKKQKEKD EQLKLDTEAA SKKAAAEKLE LEKQSHIKKA AEVDAVKKQK ELEEKQRLES - 13560 EAATKKADAE KLKLEEQKKK AAEIALIEIQ KEQEKLAQEQ SRLEDEAKKS AEKQKLESET - 13620 KSKQTEEAPK ESVDEKPKKK VLKKKTEKSD SSISQKSKSA KSTVDAAETL ESDFNLVEKK - 13680 TVQKVEQSPD ESTSATIKRD PAQKTEEISK QDDGDEKKTT TDGKPPKPED SEATPKKRVV - 13740 KKKTQKSDSV ASDASLADVS KLSDDVEEKP KKKVLKKKTE KSDSVISETS SVDTIKPESV - 13800 EIPTEKAEQM ILHNRFSTDS AVESEPKNAH KDDTEKTTDD MMTRRKSSAI FSDDEQSISS - 13860 KTSSEGRRRR RRTGFASKFA SDTLALRGDN VEIEAELLAE DDTVTWKVNG KDADLNSRCH - 13920 EMSHTFFRTL IIDEVEPTDS GMEITATCGT ESHTTILKVE ELPVDFVKYL PRKTSGKEGQ - 13980 EVTISVTLNH PIDISKVVWL KDGKPLEINK DYSIDTVGCS VSLTLRRAKY EDSGKYKVVC - 14040 DGVDCSTHLS IQGKPVLKNV SETKPVITVD KDDQFSLLVA YDSNPEASFS MTVDGKDLEF - 14100 DGRSRIDVVD DGLKLTKRGV SKTDAGEYEV KLKNEFGEVA QKFDVKVNDT PSAPGDVSVV - 14160 KAESDCLHIE WTAPTEDNGA EVTSYVIEKK ESGRRKFHKV ATVNGKKTSY VVDDLEIETP - 14220 YIVRIAAVNK FGTGEFIETK PVQTGSPFQV PTVEFPPTID NVTSTSCSLS WPKPIEDGGS - 14280 PVYGYDVYKR ENEGEWQKMN GEELVFTESF NVRALSSGKE YEFKIEACNE AGLRSNSNVV - 14340 SKKLTVEGLV PEIILDMPMV KVLDNDKVEV TWKSDGEKEF VVQYKSDGSS IWASVDIGGP - 14400 RSESAATSKC IIDGLREGIP YVFRVAARNQ HGTGEFSEPT IPVVVLADDA PRVLKAIKPV - 14460 KIPKKGELRL ECHAAGHPAP EYIWYKDGKE IIPTDENTEI VNEGSMSALI IHELAGEDVG - 14520 LYKVLVENIH GTAESEAEVG ISDVRAHFNS SFSELTEIEE GHDIELTCEV SDEEAVVNWY - 14580 KDGKKLVASD RVQFYAMARK RTLRIKGSTD ADSGVYKCET TDGRSRTEGE VIVNEQEPHI - 14640 LVGPQDAIVK DFGETMVLFC ETSKPVRKVK WFKNGVEIWP QMNKAIMEND GKRATLEIKN - 14700 FDKHDIGAYT ASVSEKETSA PAKLVFEVAP NLIIPTEIRD GVTVHAGNEF DFAVEFSGFP - 14760 IPTIHLTNNG TPLKAIAVVT EYDDSVSVRM KDVTLDNSGT VRVIAESPLG QCIKEIPLKI - 14820 IDKPSAPCDL QFKEVTEDSV FLSWQPPLET NGAPLTGYVI ERKAVDNNRW RPCGQVKPTK - 14880 LTFVAEDLFC NQVYGFRILA VNEVGESEPC DTVDVLTLES SEPVSESSEL FVPKIAILRT - 14940 PQVTVAVDET KVTLRWEECP ETSLYKVERK KVGDSDWLEI ANTDRNKFKD RSLTESGEYV - 15000 YQVTATGIHA VSSPSEETNP VKILVPGSEM PASKTEKKTD AAKSESEQKS AEEIVAEKQV - 15060 DQSQASESTT EAVEEKKTKK VVKKKVAENK GEETLQEVKE KLKKGKAVEK VQDESRRGSL - 15120 QASSDNESVT TTSEKRSEAE LEKNSEKSAE KKSTSADLEA ADKAETEKSE TGKETTEKKK - 15180 KVVKKVAKKG LVKADKSKIE LTAGKEGEIS AQVAETGVSV EWKKDGKALD ASYTVTSTGG - 15240 VSTVKIPIVD VNTSGVFTCK VKSSEGDEEE VSIAVTVKLP EVPKVEAEQS IVEVKVGDVA - 15300 KLSAKISEPA SSVNWTKDDK PIKEDGNVKA QLSPDGTAQL TISKTDSAHS GIYKLNVEND - 15360 AGKGKVEIAL RIKGAAKGAP GIPTGPIVFD DVTESSAEFS WKAPENNGGC EITGYNVERK - 15420 ESKNKGWKQC GKTKELKFKA DGLEEGTDYD VKVSAVNTMG TGSALEGKIT TLKKKEETGK - 15480 QKSEKSESDE KKSESDKVSE LKQIGKPEYV SSTATSIALK WTSDNDEVTY TVQMKEANSK - 15540 RPWAVVAKEI SECSATIAQL KEGTSYLFRV IAQNKTGQTV TSEQSESIEC KDTTESKKPA - 15600 FTNAPTDLTA VKNGKTKITA EFTGHPAPEI HWFKNKKEIF SGKRQWIENI AGATSLTIGE - 15660 MREDDEGEYK IVVKNTAGSV EHSCKLTMDQ LPEINRVDRY ASTLVFDKGE TVKLRLSFSG - 15720 RPQPEVIWID NNGKVIEESR KMKIEKTVLN TVLTINSIDS QDQGEFALKI KNRCGEDKYA - 15780 IGIQVTDRPA APGKPAVEDQ NVDSVRLRWA APTNDGGSPV RNYTVEMCTE KGKTWTKAEV - 15840 TKQAFITLFN LVPGESYRFR VRADNTFGQS EPSDESELVV VKNVSRVVEE PKKKEVKVKE - 15900 QESVDYERVA KDSEPSEYKT IDIHRLPNDL QAKYIIHEEL GKGAYGTVYR ATEKATGKTW - 15960 AAKMVQVRPG VKKENVIHEI SMMNQLHHEK LLNLHEAFDM GNEMWLIEEF VSGGELFEKI - 16020 LEDDSLMSEE EVRDYMHQIL LGVSHMHKNQ IVHLDLKPEN ILLKAKNSNE LKIIDFGLAR - 16080 KLDPKKSVKL LFGTPEFCAP EVVNYQPVGL STDMWTVGVI SYVLLSGLSP FLGDSDEDTL - 16140 ANVSASDWDF DDPSWDDVSD LAKDFICRLM IKDKRKRMSV QDALRHPWIT GPLLSAFNDL - 16200 SEYVKKMQPK LDKSGVPARQ KRNFLSLKRW SDDLLPIGRL AKRGAIFRRL TMDGVFERNI - 16260 AFDTDAAPSV KKQLEDIVAN VGDLIATLSC DVDGVPSPKV QWYKDDKELT VPSMKYDSFY - 16320 NEGLAELTVK NIVESDAGKY TCRATNDLGS IMTHAKLSVK ADEKKKKKSK TSPAVIEKKK - 16380 DRKTSKVVVI EEMIDMPPNF HHLLQDDEAK IGEPKILVVT NTTLPEPTVD WYHNGEHISI - 16440 NDSNYLRKHD KGRYELHILS VDSTDEGKWK AVGKNAFGEC ESEAKLTVVI PDGQYAPSFG - 16500 KQLSDVKCSE SDILKLEVNI QANPAPEINW FRNESEIEHS QHHRLQFDDG SGNYSLTIID - 16560 AYAEDSGEYK CVAKNKIGKA HTVCCVRIEE LLSKRSKKID GSKAPRFRMQ LPTPREVPQG - 16620 ADLTLVCSVS GTPHPNIKWT KDDKPIDMSN KQVRHENGVC TLHIIGARDD DQGRYVCEAE - 16680 NIHGVAQSFS VVEIKEAVDK DHVRPKFLEP LVNCSTCEGN EMVLECCVTG KPIPTITWYK - 16740 DGLKLIIENR MLQYTDRKGV SRLNIMNVVM NDDGEYTCEA VNSLGKDFTH CTVKVVDMGL - 16800 SKTRLTPVRS RSRSRSRSPS VVGGEIQRPP VVTRPLADAT VTEGNRELLE VEVDGFPTPT - 16860 IEWYHDGKLV AESRTLRTYF DGRVAFLKIY EAHEEHNGQY VCKVSNKLGA VETRAIVVVE - 16920 APDAAEHVTQ MPTFVKKLQD VVLKTAGETA TFTCQSYANP AAQVVWLHNG KALQQTKSNY - 16980 KTRLFDDNTA TLVIENVTDE LCGTYTAVAN NQFGDVHTSA QLTISGSEAK KIAASLPYFI - 17040 IELKPKINVV EGATLSIQAD LNGSPIPEVV WLKDNSELVE SDRIQMKCDG VNYQLLVRDV - 17100 GLEDEGTYTI TAENEKGKIR QNTEVSVTKS KEVKEKKEKK KVEKKDEGKK KPGRPGLPRP - 17160 SGASKTEQVT MAFDAPSEGP ADSYEVERRC PDQREWVSCG STKSLELEIK GLTPNTEYIF - 17220 RVAGKNKQGL GEWSEMTSTL KTASVGQAPQ FTISPQSKII ANRDDEFEIA VEFSGTPTPS - 17280 VKWYKENLQI VPDEKIDVAT TSTSSILNLK SQEENGTFNC LIENELGQAS ASCQVTIFNK - 17340 PASLQSTPDH SLERNLVPTL QKALNNESAQ AGQQIMLTCR ISSRSESTVA WFKDDERIES - 17400 AGRYELSSDK KSNHKLVCHA VQSQDTGKYR CVVTNKYGYA ESECNVAVED VTKFIAPSFS - 17460 ATLSDSTAIL GHNITLECKV EGSPAPEVSW TKDGERISTT RRIRQTQDEN GNCKLSISKA - 17520 ESDDMGVYVC SATSVAGVDS TSSMVMIAKT TGTDSHLVIA QTADEKHEKP RFTRAPPSLI - 17580 EVNESGQFTL IAKAVGEPKP TVTWLKDGRE ILRTNRIYHH FVTGDGESHL IAECVVSKTS - 17640 GIFSCKAENP NGTVIAETQV IVQRMKPANQ LANVAPKFTI PLTDMGIVNG HPTTLSCNVT - 17700 GSPEPTLEWI YIDDSGHKIN LTSSTTDWTE CRFGKVAELK SERVLREQRG TYQCIATNSS - 17760 GQATTQCYLL VGELSDEPAG PPRFVKCLQD TWTPLKESIE FSVELAGFPT PDLTWYHNEK - 17820 KINEGKDVKI TFPSDTTSVL SIKNVSLASL GMYFVEASNI HGVLRTAGRL NVSDERRKAE - 17880 PPQFKHVLEP VLAVQPKVAF SEEHPRASSS AATARVKKGA APMFLQGLED MDLKAGASAA - 17940 VAGKLGRKLR PHRSTTNDAD KLAKALAQSL RLDEPRASID SRPESAANAA LDEVRAAINS - 18000 RNKRVCRPKF MVKPKPRKVL EEYKSLRLKT AISGNPMPQV HWDKEGIILE TGNKYSIYND - 18060 GDFYYLEVHH VSTFDKGFYN CTAANNEGII TCTSEIDVLP NKEDSAAQVA KRKSRKEAKA - 18120 PNFIEVLPGR SQANLNESLC VECSVSAYPC ASIIWTRNSV RLLPQADRYT MSYDGECASL - 18180 KFISVTPGDE GTYACEAVNE LGSAVTNMNL QVSGVDPNAA EGIPPLFRFE KIKSVRKVVD - 18240 GSRVELAAEL VQASEPLQIR WLRNKVTIVD SPSFSYSRSE NMVFLTIADV FPEDGGEYTV - 18300 EAKNQSGIAR CTMQLDVRNN ERSVADEAPR VFDFEPTTRS DPGVSVELRA KVIGHPDPVI - 18360 SWTKAGQKLN NEEKYMMRNE GDKFILRIAN VTRADAGKYE LTAINPSGQA NAELELTVVQ - 18420 STKTVGAKPK FNESPISVQT CEKNRAELRA SFSGTPAPAC RWFYNGNELI DGLDGYTITS - 18480 SDTNSSLLIN SVDKKHFGEY LCTIRNQNGE ELANAMILSE GSSAALPQRR TIRR
|
Functional narrative |
SIMILARITY: Belongs to the protein kinase superfamily. -----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
Molecular function: ATP binding (Inferred from electronic annotation. Source: UniProtKB-KW), Rho guanyl-nucleotide exchange factor activity (Inferred from electronic annotation. Source: InterPro), protein serine/threonine kinase activity (Inferred from electronic annotation. Source: UniProtKB-KW)
|
Map of ordered and disordered regions |


Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
|
Region 1 | Type: | Disordered - Molten Globule | Name: | AAPLE | Location: | 3546 - 3795 | Length: | 250 | Region sequence: |
LEPTQEDVPKEAAPSGPTQEDVPKEEAPSEPTQEDVPKEAAPSEPTQENVPKEAAPSEPT KDVPKEAAPSEPIQEEVPKEATLSEPTQEQSEVSKRSEPVEPTQIQQAASEEETPLEETN ETVVQTNEDVKEAEVPENAEAQKVVDSSDLQVAASEIAHLAIDEAVLETSNQPSQFDSLQ EQKPSVVHENEHVRSVCVDLTFSRDSEQIVSDVIVAEVGYDEDECSTIADTITSLSSSPL YTAPVFTERL | Modification type: | Engineered
Fragment
| PDB: | | Structural/functional type: | Function arises via a molten globule to order transition | Functional classes: | Unknown
| Functional subclasses: | Unknown
| Detection methods:
- Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 7; TFE (0%, 20%, 40%, 80% v/v); K-phosphate 10 mM; KCl 150 mM)
- Circular dichroism (CD) spectroscopy, far-UV (275 K; pH: 7; KCl 150 mM; K-phosphate 10 mM; Temp range (275, 298, 323, 348K))
- Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 7; KCl 150 mM; K-phosphate 10 mM; Urea (0, 2, 5 M))
- Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 7; KCl 150 mM; K-phosphate 10 mM; NaCl 4 M)
| References:
- Forbes JG, Flaherty DB, Ma K, Qadota H, Benian GM, Wang K. "Extensive and modular intrinsically disordered segments in C. elegans TTN-1 and implications in filament binding, elasticity and oblique striation." J Mol Biol. . PubMed: 20346955
| Comments:Forbes, et al., speculate function may include acting as a structural-mechanical "force sensor."
Experiments were performed on synthesized fragment AAPLE42: (Ac-LEPTQEDVPKEAAPSGPTQEDVPKEEAPSEPTQEDVPKEAAP-NH2) 42-mer
|
Region 2 | Type: | Disordered - Molten Globule | Name: | PEVT | Location: | 4627 - 7026 | Length: | 2400 | Region sequence: |
VPETRAPTVEPTVEKHTPVDSKETSEVEPAEIVEQKDVPVPETSAPTVEPTVEKHTPVES KEKSEVQPAEIVEQKDVTCEEEIKELLTEVEVELFFSQAEVFSGLELDLLMECSEYVTTS IQKGSTAAPAQEPTVEKLAPVESKETSEVEPAEIVEQKDVPVPETSAPSVEPTVEKLAPV ESKETSEVQQAEIVEQKDVPVPETSAPSVEPTVEKLAPAESKETSEVQPAEIVEQKDVTC EEEIKELLTEVEVELFFSQAEVFSGLELDLLMECSEYVTTSIQKGSTAAPAQEPTVEKLA PVESKETSEVQQAEIIEQKDVPVPETSAPTVEPTVEKLKPVESKETSEVQQVEIIEQKDV PVPETSAPTVEPTVEKLAPVESKETSEVQQAEIIEQKDVPVPETSAPTVEPTVEKLKPVE SKETSEVQQVEIIEQKDVPVPETSAPTVEPTVEKLAPVESKETSEVQQAEIIEQKDVPVP ETSAPTVEPTVEKLKPVESKETSEVQQVEIIEQKDVPVPETSAPTVEPTVEKHAPVESKE TSEVQPAEIVEQKVVPVPETSAPTVEPTVEKLAPVESKETPEVQPAEILEQKDVTCEEEI KELLTEVEVELFFSKAEVFSGLELDLLMECSEYVTTSIQKGSTAAPAQEPTVEKLAPVES KETSEVEPAEIVEQKDVPVPETSAPTVEPTVEKLKSVESKETSEVQQAEIIEQKDVPVPE TSAPTVEPTVEKLAPVDSKETSEVEPAEIVEQKDVTCEEEIKELLTEVEVELLFSQAEVF SGLELDLLMECSEYVTTSIQKGSTAAPAQEPTVEKLAPVESKETSEVEPAEIVEQKDVPV PETSAPTVEPTVEKLKSVESKETSEVQQAEIIEQKDVPVPETSAPTVEPTVEKHAPVESK ETSEVQPAEIVEQKVVPVPETSAPTVEPTVEKLAPVESKETSEVEPAEIVEQKDVPVPET SAPTVEPTVEKLAPVESKETSEVEPAEIVEQKDVPVPETSAPTVEPTIEKLAPVESKETS EVEPAEIVEQKDVSVPETSAPTVEPTIEKLAPVESKETSEVEPAEIVEQKDVSVPETSAP TVEPTVEKLAPVESKETSEVEPAEIVEQKDVPVPETSAPTVEPTVEKLAPVESKETSEVQ PAEIVEHKDVQVPETSSPTVEPTVEKLAPVESKETSEVEPAEIVEQKDVPVPETSAPTVE PTVEKLAPVESKETSEVEPAEIVEQKDVPVPETSAPTVEPTVEKLAPVESKETSEVQPAE IVEQKDVSVPETSAPTVEPTVEKLAPVESKETSEVQPAEIVEQKDVPVPETSAPTVEPTV EKLAPVESKETSEVQPAEIVEHKDVQVPETSSPTVEPTVEKLAPVESKETSEVEPAEIVE QKDVPVPETSAPTVEPTVEKLAPVESKETSEVQPAEIVEHKDVQVPETSAPTVEPTIEKL APVESKETSEVEPAEIVEQKDVSVPETSAPTVEPTIEKLAPVESKETSEVQPAEIVEHKD VQVPETSSPTVEPTVEKLAPVESKETSEVQPAEIVEQKDVTCEEEIKELLTEVEVELFFS QAEVFSGLELDLLMECSEYVTTSIQKGSTAAPAHEPTVEKLAPVESKETSEVEPAEIVEQ KDVPVPETSAPTVEPTVEKLAPVESKETSEVEPAEIVEQKDLPVPETSAPTVEPTVEKLA PVESKKTSEVEPAEIVEQKDVPVPETSAPTVEPTVEKLAPVESKETSEVEPAEIVEQKDV PVPETSAPTVEPTVEKLAPVESKETSEVEPAEIVEQKDVPVPETSAPTVEPTIEKLAPVE SKETSEVEPAEIVEQKDVSVPETSAPTVEPTIEKLAPVESKETSEVEPAEIVEQKDVSVP ETSAPTVEPTVEKLAPVESKETSEVEPAEIVEQKDVPVPETSAPTVEPTVEKLAPVESKE TSEVQPAEIVEHKDVQVPETSSPTVEPTVEKLAPVESKETSEVEPAEIVEQKDVPVPETS APTVEPTVEKLAPVESKETSEVEPAEIVEQKDVPVPETSAPTVEPTVEKLAPVESKETSE VQPAEIVEHKDVQVPETTATTFEPTKEKLAPVDSKETSEVQTAEIVEQKDVPVPETSATT VEPTKEKLAPGESKETSEVQQAAIVEQKDVAVPETSATTVEPTKEKLAPVESKETSEIQT AEIVEQKDVPVPETSTSYVEPTKEKLAPGESKETSEVQQAAIVEQKDVPVPETSATTVEP TKEKLAPVESKETSEIQQAAVVEQKDVPVPETSATTVEPTKEKLAPVESKETSEVQQAAI VEQKDVPVPEANAPTFEPTVEKLAPVESKETSEVQQAAIVEQKDVPVPEANAPTVEPTVE KLAPVESKETSVESKETQADAKLKKEKDDKHKQEADAKLQKENDDKLKQEADAKLKKEND
| Modification type: | Engineered
Fragment
| PDB: | | Structural/functional type: | Function arises via a molten globule to order transition | Functional classes: | Unknown
| Functional subclasses: | Unknown
| Detection methods:
- Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 7; KCl 150 mM; K-phosphate 10 mM; TFE (0%, 20%, 40%, 80% v/v))
- Circular dichroism (CD) spectroscopy, far-UV (275 K; pH: 7; KCl 150 mM; K-phosphate 10 mM; Temp range (275, 298, 323, 348K))
- Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 7; KCl 150 mM; K-phosphate 10 mM; Urea (0, 2, 5 M))
- Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 7; KCl (with or without) 150 mM; K-phosphate 10 mM; NaCl 4 M)
| References:
- Forbes JG, Flaherty DB, Ma K, Qadota H, Benian GM, Wang K. "Extensive and modular intrinsically disordered segments in C. elegans TTN-1 and implications in filament binding, elasticity and oblique striation." J Mol Biol. . PubMed: 20346955
| Comments:Forbes, et al., speculate function may include acting as a structural-mechanical "force sensor."
Experiments performed on synthesized fragment PEVT39: (Ac-VPETSAPSVEPTVEKLAPVESKETSEVQQAEIVEQKDVP-NH2) 39-mer and synthesized fragment CEEEI (Ac-CEEEIKELLTEVEVELFFSQAEVFSGLELDLLMECSEYVTTSIQKGSTAAP-NH2) 51-mer. The native CEEEI inserts are contained within the PEVT peptide.
|
Region 3 | Type: | Disordered - Molten Globule | Name: | BLUE | Location: | 7013 - 8512 | Length: | 1500 | Region sequence: |
LKQEADAKLKKENDDKLKQEADAKLKKENDDKLKQEADAKLKKENDDKLKQEAAAKLKKE NDDKLKQEADAKLKKENDDKLKQEADAKLQKENDDKLKQEADAKLQKENDDKLKQEADAK LQKENDDKLKQEADAKLQKENDDKLKQEADAKLQKENDDKLKQEADAKLKKENDDKLKQE ADAKLKKEKHDKLKQEADAKLQKENDDKLKQEADAKLQKENDDKLKQEADAKLQKEKDDK LKQEADAKLKKEKDDKLKQDADAKLQKEKDDKLKQEADAKLKKEKDDKLKHEADAKLQKE KDDKLKQEADAKLKKEKDDRLKKDADAKLQKEKDDKLKQEADAKLKKEKDDKLKHEADAK LQKEKDDKLKQEADAKLKKEKDDKLKQEADAKLQKEKDDKLKQEADAKLKKEKDDKLKQE ADAKLQKEKDDKLKQEADAKLKKEKDDKLKQEADAKLQKEKDDKLKQEADAKLKKEKDDK LKQEADAKLKKEKDDKLKQDADAKLQKEKDDKLKQEADAKLKKEKDDKLKHEADAKLKKE KDDKLKQEADAKLKKEKDDKLKQDADAKLKKEKDDKLKHEADAKLQKEKDDNFKQEANAK LQKEKDDKLKQEKDDNFKQEANAKLQKEKDDKLKQEKDDKLKQEADAKLKKEKDDKLKQE ADAKLKKEKDDKLKQEADAKLKKDKDDKLKQEADAKLKKEKDDKLKQEADAKLKKDKDDK LKQEADAKLKKDKDDKLKQEADAKLKKEKDDKLKQEKNDKLKQEADAKLKKEKDDKLKQE ADAKLKKEKDDKLKQETDAKLKKDKDDKLKQEADAKLKKDKDDKLKQEADAKLKKDKDDK LKQEADGKLKKEKDNKLKQEADGKLKKEKDNKLKQEADAKLKKEKDDKLKQEADAKLKKE KDDKLKQEADAKLKKDKDDKLKQEADAKLKKEKDDKLKQEADAKLKKDKDDKLKQEANAK LQKEKDDKLKQEADAKLQKEKDDKLKQEADAKLKKEKDDKLKQEADAKLQKEKDDKLKQE ADAKLKKEKDDKLKQEADAKLQKEKDDNFKQEANAKLQKEKDDKLKQEKDDKLKQEADAK LKKEKDDKLKQEADAKLKKDKDDKLKQEADAKLKKEKDDKLKQEADAKLKKEKDDKLKQE ADAKLKKDKDDKLKQEADAKLKKDKDDKLKQEADAKLKKEKDDKLKQETDAKLKKDKDDK LKQEADAKLKKEKDDKLKQEADAKLKKEKDDKLKQEADAKLKKEKDDKLKQEADAKLKKD KDDKLKQEADAKLKKDKDDKLKQEADGKLKKEKDNKLKQEADGKLKKEKDNKLKQEADAK LKKEKDDKLKQEADAKLKKDKDDKLKQEADAKLKKEKDDKLKQEADAKLKKEKDDKLKQE ADAKLKKDKDDKLKQEADAKLKKDKDDKLKQEADAKLKKEKDDKLKQEADAKLKKDKDDK LKQEADAKLKKDKDDKLKQEADAKLKKEKGDKLKLEDQTNQSRIFEETSIEVTSLLKCKQ
| Modification type: | Engineered
Fragment
| PDB: | | Structural/functional type: | Function arises via a molten globule to order transition | Functional classes: | Unknown
| Functional subclasses: | Unknown
| Detection methods:
- Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 7; KCl 150 mM; K-phosphate 10 mM; TFE (0%, 20%, 40%, 80% v/v))
- Circular dichroism (CD) spectroscopy, far-UV (275 K; pH: 7; KCl 150 mM; K-phosphate 10 mM; Temp range (275, 298, 323, 348K))
- Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 7; KCl 150 mM; K-phosphate 10 mM; Urea (0, 2, 5 M))
- Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 7; KCl 150 mM; K-phosphate 10 mM; NaCl 4 M)
| References:
- Forbes JG, Flaherty DB, Ma K, Qadota H, Benian GM, Wang K. "Extensive and modular intrinsically disordered segments in C. elegans TTN-1 and implications in filament binding, elasticity and oblique striation." J Mol Biol. . PubMed: 20346955
| Comments:Forbes, et al., speculate function may include acting as both a structural-mechanical "force sensor" and, due to its high temperature sensitivity, as a "thermal sensor." Side-to-side oligomerization may stabilise the A-band during the process of growth.
Experiments were performed on synthesized fragment BLUE32: (Ac-LKQEADAKLKKENDDKLKQEADAKLKKENDDK-NH2) 32-mer
|
Region 4 | Type: | Disordered - Molten Globule | Name: | DispRep | Location: | 9326 - 9355 | Length: | 30 | Region sequence: |
ETVDEKPKKKVLKKKTEKSDSTISETSETS | Modification type: | Engineered
Fragment
| PDB: | | Structural/functional type: | Function arises via a molten globule to order transition | Functional classes: | Unknown
| Functional subclasses: | Unknown
| Detection methods: | References:
- Forbes JG, Flaherty DB, Ma K, Qadota H, Benian GM, Wang K. "Extensive and modular intrinsically disordered segments in C. elegans TTN-1 and implications in filament binding, elasticity and oblique striation." J Mol Biol. . PubMed: 20346955
| Comments:Forbes, et al., speculate function may include acting as a structural-mechanical "force sensor."
Experiments were performed on synthesized fragment DispRep: (Ac-ETVDEKPKKKVLKKKTEKSDSSISQKSETS-NH2) 30-mer. TNN-1 contains several regions of the 'dispersed repetitions' peptide DispRep beginning at a.a. 9326, 9777 and 12096.
|
If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us. |
Disprot-footer
|