DP00688: 2MDa_1 proteinFASTA viewXML view

General information
DisProt:DP00688
Name:2MDa_1 protein
Synonym(s):Q8ISF7_CAEEL
TTN-1
Ce titin
W05H8.8c (WormBase)
First appeared in release:Release 5.1 (05/28/2010)
UniProt:Q8ISF7
UniGene: 
SwissProt: Q8ISF7_CAEEL
TrEMBL:  
NCBI (GI):  
Source organism:Caenorhabditis elegans
Sequence length:18534
Percent disordered:22%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MEGNEKKGGG LPPTQQRHLN IDTTVGGSIS QPVSPSMSYS TDRETVMRSA SGHATVAETH - 60
LIRSIGSQSQ SYTEEHWSSE ITSFVALAPP KFIQVIKAYR VHSTDTISLV VEVASDPPAI - 120
FEWFYNEKSV LQDRDRFQVG HGINISRLKV SRPEQGVYKC VTRNPAGVST SYGYITVNAD - 180
REHLSSSKED MRLQRQHSVT YHQAPRFLTQ VPNLFVTAGS NVIIDVEVDA NPPARFSWFV - 240
NGKEYRDSIH GVEMFSPDVN RSVVRFSIPV AGEYKVVASN VHGSAMSCGH VDIQKVIELE - 300
ESTLTTSTTA FDPMTTSMRA LGNNGRNSRQ AVNMFELNYT QRSSSVPRGV RHLESHIEVS - 360
NMTGEEKKTQ QQTRTDAASI VESRFHPQPP KPPRAGTSRR FLPEPPKFVT TLPSVITVNA - 420
EEKLVLSVDV QAIPAAEFAW HVNGFEVKKS QSVVLLDEHN KSTLVLHPPV KQGKYKVTAR - 480
NDVGSDSVTT QVTRIGEVKD GAGSEPPDIV ESAVTVTCSH EEDVGSHSSL QTVRRIQEMQ - 540
EEDEVDPIKP FIEATSPKVK ESVEHPFANI LNPKKREERL SPSGKGKHLL FAPRITAHPS - 600
ESVFKILDGS PLKLRVMASS LPPATFLWML NNFELRSNQN VTIRNDEENS SEIEFQKAPN - 660
GNVTVSAKNH LGEDRWTGKV ILQYESPPPG QKITTIEKVT ESWTLEEAVI TQVVPTAADP - 720
GDRIVIIVRF DENKTSNCQF NWTINGVNIE KLEENLVAVE STEFESSLIV EKLEEQLCGE - 780
VVCVVKNQHG EVFSSSAHLR IRDDDSSFEI VPPNLPEECA PKIVEPLHSA SFLDGQAMSL - 840
RCKITANPSA AVVWSKDDVN VEDWVLNKDV TTTVLDGGVC ELLNPECFAE DAGLYKCTAT - 900
NPHGTAETAA FINVEGAEYI KDHEEAEISE SVLTDDVHII LPPKFIETLT AETDNFQQLG - 960
YVRMVATVRS VAPITVSWQK DGMDIYENEK YEVMQFADGA QILTIRAPTN LDSGVYTCTA - 1020
ESEHGVSNSS CQVELTISAE SSPESFEKVE ITPPEEVKET GIDDDIEVIL KEEVSGTAQI - 1080
EKREEEFKLL VKVADQVAST LVANVFLEAV HEAVKKIVET EDEEEDNQIE ATQEPRFETS - 1140
TDEYHVKENG TIKMAATISG HPTPFLEWYF GEEKLQVSQN VSMYYEAGTS AIILKNVQKR - 1200
QGGNYFLRAH NCHGESILPM KLTVDPIEAV THVLETSIPK VVVEQDAKEE EVRRAAEIIS - 1260
EQFAQLWVQD AQTEAVSAQA HQTPVVAEQA SEEPTLPEVV AALQEQKPSV EKAPQPQFEV - 1320
LETEDQDVVE QMQKQLPPVQ KSMSVQEEKA SSQRTPSPMN YEDKVKTIQS NLLRVNSHEA - 1380
MEPIEATNLL LNTALQLKNE HVCDETTTVI VTQQPQKYDQ LVTVVESNIE YHALRLSTSS - 1440
SSPLKFIDLE TIIQKPSTSC ESIDRMFVEK SKRTANAQHR IVVLQGMSNT FHNAITWSLK - 1500
KVKKLVGDAE AKAYADVEVV KQDETNEQVM TIIDNDTIVP QLLQVAAAAN KLKLENVSVA - 1560
LIKEGDRAHQ ELVIEYESSI DEPMFEPVHN TSHLTFHQQQ PTGPDQHVWS RRSKFEEDEA - 1620
HVVAVFVEVD ANCPDQSVEI VATVNAAYEG DNRQGIEDEP FTEVSQSLAT ESSAAPQAPK - 1680
FLRKLVNCFG RIGEPVQLKC LIAGMPQPEI EWTVDGDPIV PNDEYSIVYE DGVCILRIES - 1740
TLIEDEGEYC CTASNVAGTT FSKCYLKLSE ADDDAVDLLR QLSEIKIIDP TLSTGYPMSM - 1800
ISDEENTSHQ LLSNVLLTDK EVPITATYNE DLSRAESFRR FFESAETTVK VTELYQGESV - 1860
EAQFQQPEKR EQVSTSNTDV MFVNQKVDVM ESTVSTVGNA VRQSVSSSTN SWDYMFNDPF - 1920
PESQEINVIE NELYEPRVPL LPQKLSYKGQ EIFANTNTVE RNSKAGAKAK GEVENLKKCV - 1980
ETLLLFDAEM DMKDIKESSP KKEIISKKDQ QSLDDQIKVT QQILKDVERD LNKMERTSPG - 2040
KSLSPNKRTF APKDVEDIEA AIFSISDQLA DRQSSEEALR EALQEMILSN SSPMKELSRN - 2100
NETSKPEVLK SEIQKIPEVE TKISEVYPIV KLKQAISAIE NSLLEDTEVT EIMKRKGSDK - 2160
DKRKATRIKR VPSAHSARIT PITSNLRDRL NQLHQLTVSE DSGSLKQNEE AKEIQELFVK - 2220
IEKEINTIAE LCKEKMTKKG ADTVTHVLNS VLQHVASIIN VILVAQDHQP IEVHAETTKT - 2280
AEVSVWYSFD VHPESEDIIG IVDEEPTNRR PSSTPRGSTR SSNLTTSQDS QATTKMTVSS - 2340
EDTIEAPIAP PRKGRSLSRD AERLLEIQPR APPRRSRQSG DTLSPEPTPV LTLVKSDETP - 2400
APVRPPRSRS RHSGDELAET SPEAQPIRPP RSHSRHSGDE LEEVQPVRPP RSKSKTADAN - 2460
CLQIESMDES QYSLSCIHIQ KTNFAFTNST HETSNASVVV DLRNMAQLEC TVQSLDDLAS - 2520
IQMLCEESDY PSDTDRSLLL AGTVRYFNRA SPSLHEVSPS LNMESVSMDL KPETEPEEIV - 2580
QDVYVNVELH SVPSLSSLVE VNPNTLMQTL ASEKSSLKAA EEDEKEGEEE GEEEVTADVS - 2640
FIGRSVLSTE TLDVVLEEKD MSQMNSTLPL DYERAFSSNT IRETDILSDE SITVDSSYHK - 2700
SPEPTVDFAR SQVKSEEVTE NFSLIHKPAR RRVTGIVVNS LIYTIAANIA EDNTFDVDVV - 2760
QEPQRYNISI KVIEDIVDFT SLTIMSDCED DPPADVLVLK QDTSKLQALS YDDISVATTR - 2820
TGITVSIVAR SLNDGIYASL EEIAWGEVEM TVPDIMQMST EEKSSLQFNV TVSESNLEEA - 2880
KSLKSQVSFR SSQNSVSEMD NTISSTATIS IPSYVVKLES TATITCELNN YLPKNCTIDW - 2940
YCGKTKIIID HEQFDRISHD LLEVLIIRSV EAINGNLYSL KINEDLFPVA YLIVENTNLT - 3000
TSANILTRPE TQFVMEGQPT VITVELDDPN VIVNWLKDRR PLHENERIRL ETDGQGNHRV - 3060
IIPNTCVGDQ GTYLALTSSE SVAITLVVEE RIEEKEVMVI ASGTESEEDD VQEYLVPPGS - 3120
TATIACELEE CELKRSIRWL RDGKDIRFEQ GKTEHVQNGL KHYLVVHDAT SLDSGLYKTE - 3180
RSEEQCEETI IPRGVVATIQ CQTSEPQESI QWSKDGNIIP SDISRFEFRS LDNNQSHEMV - 3240
ISNISWSDAG VYSVLINGKS SFVSKIVVVE SELITQSVEE EPEAEPEIDV SLHIVESEQI - 3300
IELNVPQSPK LGASHETLVP IGQDDIEVID KQEAAPVVES IEETSSIGSE EFEIIEKFTE - 3360
EEVPKVAEPS EPTQADVPKI AAPLEQSQIQ QEVPTVAAPS EPTQADVPKE AAPSEPSQAD - 3420
VPKVAAPLEQ TQIQQEVPMV AAPLEPTQAD VPKVAAPLEQ SQIQQEVPTV AAPSEPTQAD - 3480
VPKEAAPSEP SQADVPKVAA PLEQTQIQQE VPMVAAPLEP IQEEVPKEAA PSEPTQEDVP - 3540
KGAAPLEPTQ EDVPKEAAPS GPTQEDVPKE EAPSEPTQED VPKEAAPSEP TQENVPKEAA - 3600
PSEPTKDVPK EAAPSEPIQE EVPKEATLSE PTQEQSEVSK RSEPVEPTQI QQAASEEETP - 3660
LEETNETVVQ TNEDVKEAEV PENAEAQKVV DSSDLQVAAS EIAHLAIDEA VLETSNQPSQ - 3720
FDSLQEQKPS VVHENEHVRS VCVDLTFSRD SEQIVSDVIV AEVGYDEDEC STIADTITSL - 3780
SSSPLYTAPV FTERLPSSAC FANSKLTLEV MFSGVPQPTI SWLIDDHELV SDGERISIKC - 3840
ENGVSAIRFF NVDRNAGGFL KCRATNCAGQ VETSCEIVAA DEISVISDSS ITSSTRPHFV - 3900
VPLPERVTHT VNDHITIKCK FSGQPLPAAM WEKDGVLLDL QKYQVTTEDG TSILKIESAS - 3960
LDDKAVYTCT IANEAGCEST SCTIDVVDDH LGLQQTGLHV MCERDQNDVE LDILVQSPNH - 4020
LGVTFNFPPV NRTLARQPPY FLLPLSDKVV IDEKCTLKCV VMGIPLVIVK WIVDGVVVTE - 4080
DDNHEIHFED GIALLRMKNI KKDKSVVQCE AINCKGKVTT SCVLTKCGVE ESEAGDLQKP - 4140
SFVLSLKDTC TTTDHATLKC IVVGTPLPDV SCSFNGVTDN SKIRSEDGIV LIQVNDVTEE - 4200
GIVVECTISN ETGSSTSNCV VKIIKQEEKN YQRPIIVFNQ AGSVNNEREL SVKVGVIASP - 4260
EPTLFWKHNG KSIEEGGDYY LIFEDGIGIL KVFNIQDGSH EFTCIAKNEY GQTTVEIPVE - 4320
IGLKTENKLT LVKTLNDIAV VDDIVQLKIV AEGDLPIEFK WFEDGQILED DSSHKITVDK - 4380
CISTLQLKLE ETGTRIITCE VSNSSSKVNA SCNVERVHNT VSDFVMTNDN STRFLAVGRK - 4440
CTRERNNTIL KAVVVARENI GDICEIDGEK IPDAYIEGNS LSIKVDTLSK KLSNVSFKVS - 4500
ASEGKVFETR KIEIAQEDTD EENFEINYSL RIDEQSGNTT YTFENSELYQ GNQSRELDNT - 4560
ERNFTVNKEK DESKKPSEVQ PAEIVEQKDV PVQETSAPTV EKLAPVESKE TPEVQAAEIV - 4620
EQKDVPVPET RAPTVEPTVE KHTPVDSKET SEVEPAEIVE QKDVPVPETS APTVEPTVEK - 4680
HTPVESKEKS EVQPAEIVEQ KDVTCEEEIK ELLTEVEVEL FFSQAEVFSG LELDLLMECS - 4740
EYVTTSIQKG STAAPAQEPT VEKLAPVESK ETSEVEPAEI VEQKDVPVPE TSAPSVEPTV - 4800
EKLAPVESKE TSEVQQAEIV EQKDVPVPET SAPSVEPTVE KLAPAESKET SEVQPAEIVE - 4860
QKDVTCEEEI KELLTEVEVE LFFSQAEVFS GLELDLLMEC SEYVTTSIQK GSTAAPAQEP - 4920
TVEKLAPVES KETSEVQQAE IIEQKDVPVP ETSAPTVEPT VEKLKPVESK ETSEVQQVEI - 4980
IEQKDVPVPE TSAPTVEPTV EKLAPVESKE TSEVQQAEII EQKDVPVPET SAPTVEPTVE - 5040
KLKPVESKET SEVQQVEIIE QKDVPVPETS APTVEPTVEK LAPVESKETS EVQQAEIIEQ - 5100
KDVPVPETSA PTVEPTVEKL KPVESKETSE VQQVEIIEQK DVPVPETSAP TVEPTVEKHA - 5160
PVESKETSEV QPAEIVEQKV VPVPETSAPT VEPTVEKLAP VESKETPEVQ PAEILEQKDV - 5220
TCEEEIKELL TEVEVELFFS KAEVFSGLEL DLLMECSEYV TTSIQKGSTA APAQEPTVEK - 5280
LAPVESKETS EVEPAEIVEQ KDVPVPETSA PTVEPTVEKL KSVESKETSE VQQAEIIEQK - 5340
DVPVPETSAP TVEPTVEKLA PVDSKETSEV EPAEIVEQKD VTCEEEIKEL LTEVEVELLF - 5400
SQAEVFSGLE LDLLMECSEY VTTSIQKGST AAPAQEPTVE KLAPVESKET SEVEPAEIVE - 5460
QKDVPVPETS APTVEPTVEK LKSVESKETS EVQQAEIIEQ KDVPVPETSA PTVEPTVEKH - 5520
APVESKETSE VQPAEIVEQK VVPVPETSAP TVEPTVEKLA PVESKETSEV EPAEIVEQKD - 5580
VPVPETSAPT VEPTVEKLAP VESKETSEVE PAEIVEQKDV PVPETSAPTV EPTIEKLAPV - 5640
ESKETSEVEP AEIVEQKDVS VPETSAPTVE PTIEKLAPVE SKETSEVEPA EIVEQKDVSV - 5700
PETSAPTVEP TVEKLAPVES KETSEVEPAE IVEQKDVPVP ETSAPTVEPT VEKLAPVESK - 5760
ETSEVQPAEI VEHKDVQVPE TSSPTVEPTV EKLAPVESKE TSEVEPAEIV EQKDVPVPET - 5820
SAPTVEPTVE KLAPVESKET SEVEPAEIVE QKDVPVPETS APTVEPTVEK LAPVESKETS - 5880
EVQPAEIVEQ KDVSVPETSA PTVEPTVEKL APVESKETSE VQPAEIVEQK DVPVPETSAP - 5940
TVEPTVEKLA PVESKETSEV QPAEIVEHKD VQVPETSSPT VEPTVEKLAP VESKETSEVE - 6000
PAEIVEQKDV PVPETSAPTV EPTVEKLAPV ESKETSEVQP AEIVEHKDVQ VPETSAPTVE - 6060
PTIEKLAPVE SKETSEVEPA EIVEQKDVSV PETSAPTVEP TIEKLAPVES KETSEVQPAE - 6120
IVEHKDVQVP ETSSPTVEPT VEKLAPVESK ETSEVQPAEI VEQKDVTCEE EIKELLTEVE - 6180
VELFFSQAEV FSGLELDLLM ECSEYVTTSI QKGSTAAPAH EPTVEKLAPV ESKETSEVEP - 6240
AEIVEQKDVP VPETSAPTVE PTVEKLAPVE SKETSEVEPA EIVEQKDLPV PETSAPTVEP - 6300
TVEKLAPVES KKTSEVEPAE IVEQKDVPVP ETSAPTVEPT VEKLAPVESK ETSEVEPAEI - 6360
VEQKDVPVPE TSAPTVEPTV EKLAPVESKE TSEVEPAEIV EQKDVPVPET SAPTVEPTIE - 6420
KLAPVESKET SEVEPAEIVE QKDVSVPETS APTVEPTIEK LAPVESKETS EVEPAEIVEQ - 6480
KDVSVPETSA PTVEPTVEKL APVESKETSE VEPAEIVEQK DVPVPETSAP TVEPTVEKLA - 6540
PVESKETSEV QPAEIVEHKD VQVPETSSPT VEPTVEKLAP VESKETSEVE PAEIVEQKDV - 6600
PVPETSAPTV EPTVEKLAPV ESKETSEVEP AEIVEQKDVP VPETSAPTVE PTVEKLAPVE - 6660
SKETSEVQPA EIVEHKDVQV PETTATTFEP TKEKLAPVDS KETSEVQTAE IVEQKDVPVP - 6720
ETSATTVEPT KEKLAPGESK ETSEVQQAAI VEQKDVAVPE TSATTVEPTK EKLAPVESKE - 6780
TSEIQTAEIV EQKDVPVPET STSYVEPTKE KLAPGESKET SEVQQAAIVE QKDVPVPETS - 6840
ATTVEPTKEK LAPVESKETS EIQQAAVVEQ KDVPVPETSA TTVEPTKEKL APVESKETSE - 6900
VQQAAIVEQK DVPVPEANAP TFEPTVEKLA PVESKETSEV QQAAIVEQKD VPVPEANAPT - 6960
VEPTVEKLAP VESKETSVES KETQADAKLK KEKDDKHKQE ADAKLQKEND DKLKQEADAK - 7020
LKKENDDKLK QEADAKLKKE NDDKLKQEAD AKLKKENDDK LKQEAAAKLK KENDDKLKQE - 7080
ADAKLKKEND DKLKQEADAK LQKENDDKLK QEADAKLQKE NDDKLKQEAD AKLQKENDDK - 7140
LKQEADAKLQ KENDDKLKQE ADAKLQKEND DKLKQEADAK LKKENDDKLK QEADAKLKKE - 7200
KHDKLKQEAD AKLQKENDDK LKQEADAKLQ KENDDKLKQE ADAKLQKEKD DKLKQEADAK - 7260
LKKEKDDKLK QDADAKLQKE KDDKLKQEAD AKLKKEKDDK LKHEADAKLQ KEKDDKLKQE - 7320
ADAKLKKEKD DRLKKDADAK LQKEKDDKLK QEADAKLKKE KDDKLKHEAD AKLQKEKDDK - 7380
LKQEADAKLK KEKDDKLKQE ADAKLQKEKD DKLKQEADAK LKKEKDDKLK QEADAKLQKE - 7440
KDDKLKQEAD AKLKKEKDDK LKQEADAKLQ KEKDDKLKQE ADAKLKKEKD DKLKQEADAK - 7500
LKKEKDDKLK QDADAKLQKE KDDKLKQEAD AKLKKEKDDK LKHEADAKLK KEKDDKLKQE - 7560
ADAKLKKEKD DKLKQDADAK LKKEKDDKLK HEADAKLQKE KDDNFKQEAN AKLQKEKDDK - 7620
LKQEKDDNFK QEANAKLQKE KDDKLKQEKD DKLKQEADAK LKKEKDDKLK QEADAKLKKE - 7680
KDDKLKQEAD AKLKKDKDDK LKQEADAKLK KEKDDKLKQE ADAKLKKDKD DKLKQEADAK - 7740
LKKDKDDKLK QEADAKLKKE KDDKLKQEKN DKLKQEADAK LKKEKDDKLK QEADAKLKKE - 7800
KDDKLKQETD AKLKKDKDDK LKQEADAKLK KDKDDKLKQE ADAKLKKDKD DKLKQEADGK - 7860
LKKEKDNKLK QEADGKLKKE KDNKLKQEAD AKLKKEKDDK LKQEADAKLK KEKDDKLKQE - 7920
ADAKLKKDKD DKLKQEADAK LKKEKDDKLK QEADAKLKKD KDDKLKQEAN AKLQKEKDDK - 7980
LKQEADAKLQ KEKDDKLKQE ADAKLKKEKD DKLKQEADAK LQKEKDDKLK QEADAKLKKE - 8040
KDDKLKQEAD AKLQKEKDDN FKQEANAKLQ KEKDDKLKQE KDDKLKQEAD AKLKKEKDDK - 8100
LKQEADAKLK KDKDDKLKQE ADAKLKKEKD DKLKQEADAK LKKEKDDKLK QEADAKLKKD - 8160
KDDKLKQEAD AKLKKDKDDK LKQEADAKLK KEKDDKLKQE TDAKLKKDKD DKLKQEADAK - 8220
LKKEKDDKLK QEADAKLKKE KDDKLKQEAD AKLKKEKDDK LKQEADAKLK KDKDDKLKQE - 8280
ADAKLKKDKD DKLKQEADGK LKKEKDNKLK QEADGKLKKE KDNKLKQEAD AKLKKEKDDK - 8340
LKQEADAKLK KDKDDKLKQE ADAKLKKEKD DKLKQEADAK LKKEKDDKLK QEADAKLKKD - 8400
KDDKLKQEAD AKLKKDKDDK LKQEADAKLK KEKDDKLKQE ADAKLKKDKD DKLKQEADAK - 8460
LKKDKDDKLK QEADAKLKKE KGDKLKLEDQ TNQSRIFEET SIEVTSLLKC KQQAIIVSKS - 8520
FALCERVVLN AEEPFTLEVF CNAVFVKQRT DKIGIGIIFE RSGASKKDES RPDRLDDNCV - 8580
LTDVTDGLSI LSPPPKAKKH LKKKKKHHKK EKIAVKETEQ DEKTVSHLKP EISGMERKRS - 8640
NSGSSDIFVD VDIEAGEESI HTDALVDLNF YDYDQMELSI FEDYDSDDDS ASIDCDVSLS - 8700
NVAADDGIDV FPSDGDTQEV EQKVTLPKKH QSDEDVISKE EENLETSVSY GSIEETVSFT - 8760
IGTGQSIIEH PKSHAVGQMN SEVIIKCKTS QPISDAKWFC NGMVLLPDEQ VNMTVTGCEA - 8820
VLRLVKFLPQ NKGNYHVLID GSIGSQPAIL SGPVPPVILN KLTKPITHQA GKSFTYKFNF - 8880
MGAPAPRLRV LSNGEPVSFD VKYEIYDNIA SLYIPKMSKR DGGEYTVVLE NKYGKDESDL - 8940
HITMVDTPLK PRKAQLVALT DTSATFKWLP PHTGESDILH YIVMRRSTES RRWRNIGHVQ - 9000
EKTFTAIELV PNEFYAFRIV AVNGFGEGAP SEIIEVNTLD YDQEESFDFA GEEELKLDDV - 9060
QVNNEVVTEI TIEESEVTIE EHRKLKKKSK KSKKTTDEPE LDSEIALEVS SDITSSLEIT - 9120
TESTIPDTAP ESQETLNVEI AVTETTVQKI TNPSDESAKK DVNEDTAVSS IVKKDDKDVN - 9180
KKSLPESGLT TKKEIQGKPE KKIMKKKTEK ADSSISETSE TLTKDLTQTK QSEPEPAKRT - 9240
TETSVQDEVK RKTETTSKSK QTTEEHPQPG GKSDSSISST SDASEVKQVQ QSESEAQKVT - 9300
EKPETAKLES KSKMTEDTTK ESDNKETVDE KPKKKVLKKK TEKSDSTISE TSETSAVESA - 9360
GPSESETQNV AAVDKEKKQK ETDEKQKLEA EIAGKKSTEQ KSKLEAEAKL KRAAEEDAAK - 9420
KQKEKTEAAS KKAAAEKLEL EKQAQINKAA EADAVKKQNE LDEQNKLEAT KKLAAEKLKL - 9480
EEQSAAKSKQ AAEEQAKLDA QTKAKAAEKQ TGLEKDEKSN KDSGSNETVE EKPKKKVLKK - 9540
KTEKSDSSIS QKSDTSKTVA ESAGSSESET QKVADATSKQ KETDKKQKLE AEITAKKSAD - 9600
EKSKLETESK LIKAAEDAAK KQKEKEDKLK LEADVASKKA AAEKLELEKQ AQIKKAAEAD - 9660
AVKKQKELAE KQKLESEAAT KKAAAEKLKL EEQAQINKAA EADAVKKQKE LDEKNKLEAN - 9720
KKSAAEKLKL EEESAAKSKQ TVEEQAKLDA QTKEKTAEKQ TGLEKDDKST KDSESKETVD - 9780
EKPKKKVLKK KTEKSDSSIS QKSVTSKTVV ESGGPSESET QKVADAARKQ KETDEKQKLE - 9840
AEITAKKSAD EKSKLEAESK LKKAAEVEAA KKQKEKDEQL KLDTEAASKK AAAEKLELEK - 9900
QAQIKKAAEA DAVKKEKELA EKQKLESEAA TKKAAAEKLK LEEQKKKDAE TASIEKQKEQ - 9960
EKLAQEQSKL EVDAKKSAEK QKLESETKSK KTEEAPKESV DEKPKKKVLK KKTEKSDSSI - 10020
SQKSDTAKTV AESAGQSDSE TQKVSEADKA HKQKESDEKQ KLESEIAAKK SAEQKSKLET - 10080
EAKTKKVIED ESAKKQKEQE DKKKGDDSAK KQKDQKEKQK LESEATSKKP TSEKQKDEKT - 10140
PQEKAKSENE TVMTTEPQQL EVKSEPKKSD KTETVEKEVA SSTEKSDDSK TKEPKEKKKI - 10200
IKKKKDTTKP QEASKELSSD ESRIDLESDI SLSLDTVTES DDLSTASTIK LQKESDESGI - 10260
DSRMGQTSEA EDSPFISQPV SATVTEMAGE AKFTVKFSRK PIYVKWMRDD REIRVAYGKA - 10320
SVETTDDSSV LVIKNIDGKD VGNIYAVFDS EYRSAMARLD LRVPCKITLE SSSNAPEIVA - 10380
GKNLDLSFKI SGYPLPTNIE LLHNNENLRT RSDVTDFDDS ISIRMKRLKL EDSGEIKIIG - 10440
KNDSSEDQLR IPINVIEVTS KPTSLQVTST ERETVTLTWS LPTELNGSNV NEYLVERKTV - 10500
DGGRWRHACT VTDSRAVVDG LFSGTEYVFR VVAVNGAGQS APSDTIEATT QAEEEIDETV - 10560
PTSPVEKVKE PVSKKPENTK ESEGHKKRDR KESEDHDENN LGKSGKDEFA TSGESGTSNQ - 10620
NEESAQLNTS FTSTEQHGQT EKQVRKGTRK SLTRSLNIRE SDIDADVVEV EYDEQGDDIP - 10680
SDPTTSGTYA FDKIEEEPAR TSGEMAMAEK DSDAMEVRGL NKKLSKKGGK EGTSTEKSSS - 10740
KTKKQEKSAL SVQEMNKSLK KKGEKGEAET AASDFIENAD QTGMSIQDLN KSMKKKVESG - 10800
EATGQINDAS NNKDADELSI QDSQQSLKKK SENESVTGEQ LDKSQEVEDD KMTIQSLKKS - 10860
IKKKPESREV SGGKSEKSKE KESDEMSIQQ LNKSVKKKPE NEAVTQGKSG KSQEQESDKM - 10920
SIQALNKSMK KKDGVDGVEG NINIGRSDGD QLSVNDIDAE LSTSEQVENA SQNLGATADS - 10980
DGDSLSLQTL KKRISKKGIH GEAESKLGEK QSGSDSFTLQ DLYEELKAKE DAVEAGAETS - 11040
NADQSAEKTS LEVRDMKKKM KKKQVSGTAE NLIGESNRDE TSMEIRDLNT QHSNQTGEDE - 11100
SSTFNFGQKD QEQYSMVMKD VSKKLARQNA EEIQSGKLIP TTNEEKTGLA LTGKNKNLKK - 11160
GEENEKTKFE AKHLGSSSAS DSLAESTLRS KKTKKGEVEK SELSIDMKNQ DKTTLATTLL - 11220
EDDLAKTTSA EESEAEHLVA LQNKEKTSLA MRRKRVSFDS STKSESIEDV IPDKNRDSDK - 11280
MSITGIKKKM SQKSESAEAQ KNESPEVKEI SSFEEKTLKS KKKSKADRNQ GTEANLGDKT - 11340
IDKDYLSVTD KNQSLEKSEA SGQAEKSIKA PNKSKVTTSF ADESLTSELD RLMADEEMAE - 11400
MMFAEEEKAA DLLNVMNKNK GLNKSEQEES QEISLKSQSK VKDSDSLSST DKKIGLKKSD - 11460
KDQKLGTSKI FGSKDQESVG YEEKTSNFSK QRRGVSDLGS DAMTDQKNVQ ESQYAEISAD - 11520
DHMSKTGADG EISATRTIVD GSDAAQGSEY AEISKKRKFK RAEQIGEAET SLCDSRENTH - 11580
DSLSISDVNP ELRRSNVEIS AFGQIDLTAE EVTSLTDINK DAQLTKKQDE NDAKKSVSKN - 11640
LKAGAKKDSD TLSITSKKDK FGKRQDSREA SATVEQQGEE KVTKNLKGSR GKKEKLGDAG - 11700
IDVNFENQEE FASTTGDIES IVSEKGHDTY SEKTVKSSKK KSPQTAGAEY GGSESLNASS - 11760
ALSTTDVDAQ LKNQEKDGVA ESSIGKSNQK DSYSEQELNV NKKKKQAVGA AMNQGSGSTK - 11820
ESDNLAVASV ESNLAKDSAN QEASLHGLVD NDATSLSQLD SEHRLKKRDD ELSAHTKLGK - 11880
HTQSENIALT ETDDSLVKGD SEESAELNIK QQGETAEDKY VESRKKTTLK KKPEQKQVTD - 11940
TLSAVDGRHD TTSLSVADSG ISFDKSMENE LAGSGDGTAS ASVSAKVRGA DGNAKTNLIS - 12000
SFEKPGQESK TSKTLSGKQK KQEKSSFAEK NAGFDLSMGE GKNDESVESS LQKNRDADSL - 12060
ALQGTDLAFS KPSDSSANAH LDMPQRELTL RICQAETVDW SDDSEVEEGT RTSAPGEVKK - 12120
KKKFIISAIS QDGEFSDAES ITFDENGVRV EKRRRKKRDP KEYMGAGELA MRIPAFAKKM - 12180
QYIGCIEGDV VVFTIKVVSD DVPLIRMYRN DFPVANFDKM AFEGFTKGSE HSFNVTINDI - 12240
RKLDGGKLVF EAKNDYGVDK CTILLDVRDS GSFIEDYSEI HRSAEIQNSV GDVQVKEGET - 12300
AKLTGRVDGF PLPELIWIKN GKEIDMMVPS TKYQLDYHSD GEFEARIANC TFEDDDDYSL - 12360
LVENLAGVDS CNFQVFVDCN EYPDDEHFNR RRRLQRGRRV MEASSDSELD DAKKRKKRRI - 12420
KRVVERRNPN APRLTQLIPP RFDKILSDHD AIEGENVVMM VETLGEPEPQ VRFYRDGKLI - 12480
DDGSGDRMEV RHEDEMRKHW LILKDICKDE EAEYACQAIN VAGEAWCFSD VVVHMSEESR - 12540
DDDKSVDEVD DSTVLEEKKD DGDDKSKPKT KKKIIKKKET PESEQVTAAE PEQQKISEVD - 12600
VQSVAETEVG AKKKPDAEKP TDLSKAKKDS KSKKSDEPEA STEEKSTTEK PTNDKTSKKS - 12660
AEKKTVKPKK EVTGKPLEAK KPVEDKKDAS QPSSSKESSP PTDGKKKKQI PKALFIPDEI - 12720
SSRFGDPSTM HSETNITTTI RGREGSADAK TPLVEPLSAS VSMKVESAKE KAEFSFKRRS - 12780
ETPDDKSRKK EGLPPAKKSE KKDEVTAEKQ STEALIESKK KEVDESKISE QQPSDKNKSE - 12840
VVGVPEKAAG PETKKDVSEI EEVPKKKTIK KKTEKSDSSI SQKSNVLKPA DDDKSKSDDV - 12900
TDKSKKTTED QTKVATDSKL EKAADTTKQI ETETVVDDKS KKKVLKKKTE KSDSFISQKS - 12960
ETPPVVEPTK PAESEAQKIA EVNKAKKQKE VDDNLKREAE VAAKKIADEK LKIEAEANIK - 13020
KTAEVEAAKK QKEKDEQLKL ETEVVSKKSA AEKLELEKQA QIKKAAEADA VKKQKELNEK - 13080
NKLEAAKKSA ADKLKLEEES AAKSKKVSEE SVKFGEEKKT KAGEKTVQVE SEPTSKKTID - 13140
TKDVGATEPA DETPKKKIIK KKTEKSDSSI SQKSATDSEK VSKQKEQDEP TKPAVSETQM - 13200
VTEADKSKKQ KETDEKLKLD AEIAAKTKQE ADEKSKLDAQ EKIKKVSEDD AARKEKELND - 13260
KLKLESEIAT KKASADKLKL EEQAQAKKAA EVEAAKKQKE KDEQLKLDTE AASKKAAAEK - 13320
LELEKQAQIK KAAGADAVKK QKELDEKNKL EANKKSAAGK LKIEEESAAK SKQTVEEQAK - 13380
LDAQTKAKTA EKQTKLEKDE KSTKESESKE TVDEKPKKKV LKKKTEKSDS SISQKSETSK - 13440
TVVESAGPSE SETQKVADAA RKQKETDEKQ KLEAEITAKK SADEKSKLEA ESKLKKAAEV - 13500
EAAKKQKEKD EQLKLDTEAA SKKAAAEKLE LEKQSHIKKA AEVDAVKKQK ELEEKQRLES - 13560
EAATKKADAE KLKLEEQKKK AAEIALIEIQ KEQEKLAQEQ SRLEDEAKKS AEKQKLESET - 13620
KSKQTEEAPK ESVDEKPKKK VLKKKTEKSD SSISQKSKSA KSTVDAAETL ESDFNLVEKK - 13680
TVQKVEQSPD ESTSATIKRD PAQKTEEISK QDDGDEKKTT TDGKPPKPED SEATPKKRVV - 13740
KKKTQKSDSV ASDASLADVS KLSDDVEEKP KKKVLKKKTE KSDSVISETS SVDTIKPESV - 13800
EIPTEKAEQM ILHNRFSTDS AVESEPKNAH KDDTEKTTDD MMTRRKSSAI FSDDEQSISS - 13860
KTSSEGRRRR RRTGFASKFA SDTLALRGDN VEIEAELLAE DDTVTWKVNG KDADLNSRCH - 13920
EMSHTFFRTL IIDEVEPTDS GMEITATCGT ESHTTILKVE ELPVDFVKYL PRKTSGKEGQ - 13980
EVTISVTLNH PIDISKVVWL KDGKPLEINK DYSIDTVGCS VSLTLRRAKY EDSGKYKVVC - 14040
DGVDCSTHLS IQGKPVLKNV SETKPVITVD KDDQFSLLVA YDSNPEASFS MTVDGKDLEF - 14100
DGRSRIDVVD DGLKLTKRGV SKTDAGEYEV KLKNEFGEVA QKFDVKVNDT PSAPGDVSVV - 14160
KAESDCLHIE WTAPTEDNGA EVTSYVIEKK ESGRRKFHKV ATVNGKKTSY VVDDLEIETP - 14220
YIVRIAAVNK FGTGEFIETK PVQTGSPFQV PTVEFPPTID NVTSTSCSLS WPKPIEDGGS - 14280
PVYGYDVYKR ENEGEWQKMN GEELVFTESF NVRALSSGKE YEFKIEACNE AGLRSNSNVV - 14340
SKKLTVEGLV PEIILDMPMV KVLDNDKVEV TWKSDGEKEF VVQYKSDGSS IWASVDIGGP - 14400
RSESAATSKC IIDGLREGIP YVFRVAARNQ HGTGEFSEPT IPVVVLADDA PRVLKAIKPV - 14460
KIPKKGELRL ECHAAGHPAP EYIWYKDGKE IIPTDENTEI VNEGSMSALI IHELAGEDVG - 14520
LYKVLVENIH GTAESEAEVG ISDVRAHFNS SFSELTEIEE GHDIELTCEV SDEEAVVNWY - 14580
KDGKKLVASD RVQFYAMARK RTLRIKGSTD ADSGVYKCET TDGRSRTEGE VIVNEQEPHI - 14640
LVGPQDAIVK DFGETMVLFC ETSKPVRKVK WFKNGVEIWP QMNKAIMEND GKRATLEIKN - 14700
FDKHDIGAYT ASVSEKETSA PAKLVFEVAP NLIIPTEIRD GVTVHAGNEF DFAVEFSGFP - 14760
IPTIHLTNNG TPLKAIAVVT EYDDSVSVRM KDVTLDNSGT VRVIAESPLG QCIKEIPLKI - 14820
IDKPSAPCDL QFKEVTEDSV FLSWQPPLET NGAPLTGYVI ERKAVDNNRW RPCGQVKPTK - 14880
LTFVAEDLFC NQVYGFRILA VNEVGESEPC DTVDVLTLES SEPVSESSEL FVPKIAILRT - 14940
PQVTVAVDET KVTLRWEECP ETSLYKVERK KVGDSDWLEI ANTDRNKFKD RSLTESGEYV - 15000
YQVTATGIHA VSSPSEETNP VKILVPGSEM PASKTEKKTD AAKSESEQKS AEEIVAEKQV - 15060
DQSQASESTT EAVEEKKTKK VVKKKVAENK GEETLQEVKE KLKKGKAVEK VQDESRRGSL - 15120
QASSDNESVT TTSEKRSEAE LEKNSEKSAE KKSTSADLEA ADKAETEKSE TGKETTEKKK - 15180
KVVKKVAKKG LVKADKSKIE LTAGKEGEIS AQVAETGVSV EWKKDGKALD ASYTVTSTGG - 15240
VSTVKIPIVD VNTSGVFTCK VKSSEGDEEE VSIAVTVKLP EVPKVEAEQS IVEVKVGDVA - 15300
KLSAKISEPA SSVNWTKDDK PIKEDGNVKA QLSPDGTAQL TISKTDSAHS GIYKLNVEND - 15360
AGKGKVEIAL RIKGAAKGAP GIPTGPIVFD DVTESSAEFS WKAPENNGGC EITGYNVERK - 15420
ESKNKGWKQC GKTKELKFKA DGLEEGTDYD VKVSAVNTMG TGSALEGKIT TLKKKEETGK - 15480
QKSEKSESDE KKSESDKVSE LKQIGKPEYV SSTATSIALK WTSDNDEVTY TVQMKEANSK - 15540
RPWAVVAKEI SECSATIAQL KEGTSYLFRV IAQNKTGQTV TSEQSESIEC KDTTESKKPA - 15600
FTNAPTDLTA VKNGKTKITA EFTGHPAPEI HWFKNKKEIF SGKRQWIENI AGATSLTIGE - 15660
MREDDEGEYK IVVKNTAGSV EHSCKLTMDQ LPEINRVDRY ASTLVFDKGE TVKLRLSFSG - 15720
RPQPEVIWID NNGKVIEESR KMKIEKTVLN TVLTINSIDS QDQGEFALKI KNRCGEDKYA - 15780
IGIQVTDRPA APGKPAVEDQ NVDSVRLRWA APTNDGGSPV RNYTVEMCTE KGKTWTKAEV - 15840
TKQAFITLFN LVPGESYRFR VRADNTFGQS EPSDESELVV VKNVSRVVEE PKKKEVKVKE - 15900
QESVDYERVA KDSEPSEYKT IDIHRLPNDL QAKYIIHEEL GKGAYGTVYR ATEKATGKTW - 15960
AAKMVQVRPG VKKENVIHEI SMMNQLHHEK LLNLHEAFDM GNEMWLIEEF VSGGELFEKI - 16020
LEDDSLMSEE EVRDYMHQIL LGVSHMHKNQ IVHLDLKPEN ILLKAKNSNE LKIIDFGLAR - 16080
KLDPKKSVKL LFGTPEFCAP EVVNYQPVGL STDMWTVGVI SYVLLSGLSP FLGDSDEDTL - 16140
ANVSASDWDF DDPSWDDVSD LAKDFICRLM IKDKRKRMSV QDALRHPWIT GPLLSAFNDL - 16200
SEYVKKMQPK LDKSGVPARQ KRNFLSLKRW SDDLLPIGRL AKRGAIFRRL TMDGVFERNI - 16260
AFDTDAAPSV KKQLEDIVAN VGDLIATLSC DVDGVPSPKV QWYKDDKELT VPSMKYDSFY - 16320
NEGLAELTVK NIVESDAGKY TCRATNDLGS IMTHAKLSVK ADEKKKKKSK TSPAVIEKKK - 16380
DRKTSKVVVI EEMIDMPPNF HHLLQDDEAK IGEPKILVVT NTTLPEPTVD WYHNGEHISI - 16440
NDSNYLRKHD KGRYELHILS VDSTDEGKWK AVGKNAFGEC ESEAKLTVVI PDGQYAPSFG - 16500
KQLSDVKCSE SDILKLEVNI QANPAPEINW FRNESEIEHS QHHRLQFDDG SGNYSLTIID - 16560
AYAEDSGEYK CVAKNKIGKA HTVCCVRIEE LLSKRSKKID GSKAPRFRMQ LPTPREVPQG - 16620
ADLTLVCSVS GTPHPNIKWT KDDKPIDMSN KQVRHENGVC TLHIIGARDD DQGRYVCEAE - 16680
NIHGVAQSFS VVEIKEAVDK DHVRPKFLEP LVNCSTCEGN EMVLECCVTG KPIPTITWYK - 16740
DGLKLIIENR MLQYTDRKGV SRLNIMNVVM NDDGEYTCEA VNSLGKDFTH CTVKVVDMGL - 16800
SKTRLTPVRS RSRSRSRSPS VVGGEIQRPP VVTRPLADAT VTEGNRELLE VEVDGFPTPT - 16860
IEWYHDGKLV AESRTLRTYF DGRVAFLKIY EAHEEHNGQY VCKVSNKLGA VETRAIVVVE - 16920
APDAAEHVTQ MPTFVKKLQD VVLKTAGETA TFTCQSYANP AAQVVWLHNG KALQQTKSNY - 16980
KTRLFDDNTA TLVIENVTDE LCGTYTAVAN NQFGDVHTSA QLTISGSEAK KIAASLPYFI - 17040
IELKPKINVV EGATLSIQAD LNGSPIPEVV WLKDNSELVE SDRIQMKCDG VNYQLLVRDV - 17100
GLEDEGTYTI TAENEKGKIR QNTEVSVTKS KEVKEKKEKK KVEKKDEGKK KPGRPGLPRP - 17160
SGASKTEQVT MAFDAPSEGP ADSYEVERRC PDQREWVSCG STKSLELEIK GLTPNTEYIF - 17220
RVAGKNKQGL GEWSEMTSTL KTASVGQAPQ FTISPQSKII ANRDDEFEIA VEFSGTPTPS - 17280
VKWYKENLQI VPDEKIDVAT TSTSSILNLK SQEENGTFNC LIENELGQAS ASCQVTIFNK - 17340
PASLQSTPDH SLERNLVPTL QKALNNESAQ AGQQIMLTCR ISSRSESTVA WFKDDERIES - 17400
AGRYELSSDK KSNHKLVCHA VQSQDTGKYR CVVTNKYGYA ESECNVAVED VTKFIAPSFS - 17460
ATLSDSTAIL GHNITLECKV EGSPAPEVSW TKDGERISTT RRIRQTQDEN GNCKLSISKA - 17520
ESDDMGVYVC SATSVAGVDS TSSMVMIAKT TGTDSHLVIA QTADEKHEKP RFTRAPPSLI - 17580
EVNESGQFTL IAKAVGEPKP TVTWLKDGRE ILRTNRIYHH FVTGDGESHL IAECVVSKTS - 17640
GIFSCKAENP NGTVIAETQV IVQRMKPANQ LANVAPKFTI PLTDMGIVNG HPTTLSCNVT - 17700
GSPEPTLEWI YIDDSGHKIN LTSSTTDWTE CRFGKVAELK SERVLREQRG TYQCIATNSS - 17760
GQATTQCYLL VGELSDEPAG PPRFVKCLQD TWTPLKESIE FSVELAGFPT PDLTWYHNEK - 17820
KINEGKDVKI TFPSDTTSVL SIKNVSLASL GMYFVEASNI HGVLRTAGRL NVSDERRKAE - 17880
PPQFKHVLEP VLAVQPKVAF SEEHPRASSS AATARVKKGA APMFLQGLED MDLKAGASAA - 17940
VAGKLGRKLR PHRSTTNDAD KLAKALAQSL RLDEPRASID SRPESAANAA LDEVRAAINS - 18000
RNKRVCRPKF MVKPKPRKVL EEYKSLRLKT AISGNPMPQV HWDKEGIILE TGNKYSIYND - 18060
GDFYYLEVHH VSTFDKGFYN CTAANNEGII TCTSEIDVLP NKEDSAAQVA KRKSRKEAKA - 18120
PNFIEVLPGR SQANLNESLC VECSVSAYPC ASIIWTRNSV RLLPQADRYT MSYDGECASL - 18180
KFISVTPGDE GTYACEAVNE LGSAVTNMNL QVSGVDPNAA EGIPPLFRFE KIKSVRKVVD - 18240
GSRVELAAEL VQASEPLQIR WLRNKVTIVD SPSFSYSRSE NMVFLTIADV FPEDGGEYTV - 18300
EAKNQSGIAR CTMQLDVRNN ERSVADEAPR VFDFEPTTRS DPGVSVELRA KVIGHPDPVI - 18360
SWTKAGQKLN NEEKYMMRNE GDKFILRIAN VTRADAGKYE LTAINPSGQA NAELELTVVQ - 18420
STKTVGAKPK FNESPISVQT CEKNRAELRA SFSGTPAPAC RWFYNGNELI DGLDGYTITS - 18480
SDTNSSLLIN SVDKKHFGEY LCTIRNQNGE ELANAMILSE GSSAALPQRR TIRR



Functional narrative    

SIMILARITY: Belongs to the protein kinase superfamily.
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Molecular function: ATP binding (Inferred from electronic annotation. Source: UniProtKB-KW), Rho guanyl-nucleotide exchange factor activity (Inferred from electronic annotation. Source: InterPro), protein serine/threonine kinase activity (Inferred from electronic annotation. Source: UniProtKB-KW)

Region 1: 3546-3795 Region 2: 4627-7026 Region 3: 7013-8512 Region 4: 9326-9355

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered - Molten Globule
Name:AAPLE
Location:3546 - 3795
Length:250
Region sequence:

LEPTQEDVPKEAAPSGPTQEDVPKEEAPSEPTQEDVPKEAAPSEPTQENVPKEAAPSEPT
KDVPKEAAPSEPIQEEVPKEATLSEPTQEQSEVSKRSEPVEPTQIQQAASEEETPLEETN
ETVVQTNEDVKEAEVPENAEAQKVVDSSDLQVAASEIAHLAIDEAVLETSNQPSQFDSLQ
EQKPSVVHENEHVRSVCVDLTFSRDSEQIVSDVIVAEVGYDEDECSTIADTITSLSSSPL
YTAPVFTERL

Modification type: Engineered
Fragment
PDB:  
Structural/functional type: Function arises via a molten globule to order transition
Functional classes: Unknown
Functional subclasses: Unknown
Detection methods:
  1. Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 7; TFE (0%, 20%, 40%, 80% v/v); K-phosphate 10 mM; KCl 150 mM)

  2. Circular dichroism (CD) spectroscopy, far-UV (275 K; pH: 7; KCl 150 mM; K-phosphate 10 mM; Temp range (275, 298, 323, 348K))

  3. Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 7; KCl 150 mM; K-phosphate 10 mM; Urea (0, 2, 5 M))

  4. Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 7; KCl 150 mM; K-phosphate 10 mM; NaCl 4 M)

References:
  1. Forbes JG, Flaherty DB, Ma K, Qadota H, Benian GM, Wang K. "Extensive and modular intrinsically disordered segments in C. elegans TTN-1 and implications in filament binding, elasticity and oblique striation." J Mol Biol. . PubMed: 20346955

Comments:
Forbes, et al., speculate function may include acting as a structural-mechanical "force sensor."


Experiments were performed on synthesized fragment AAPLE42: (Ac-LEPTQEDVPKEAAPSGPTQEDVPKEEAPSEPTQEDVPKEAAP-NH2) 42-mer




Region 2
Type:Disordered - Molten Globule
Name:PEVT
Location:4627 - 7026
Length:2400
Region sequence:

VPETRAPTVEPTVEKHTPVDSKETSEVEPAEIVEQKDVPVPETSAPTVEPTVEKHTPVES
KEKSEVQPAEIVEQKDVTCEEEIKELLTEVEVELFFSQAEVFSGLELDLLMECSEYVTTS
IQKGSTAAPAQEPTVEKLAPVESKETSEVEPAEIVEQKDVPVPETSAPSVEPTVEKLAPV
ESKETSEVQQAEIVEQKDVPVPETSAPSVEPTVEKLAPAESKETSEVQPAEIVEQKDVTC
EEEIKELLTEVEVELFFSQAEVFSGLELDLLMECSEYVTTSIQKGSTAAPAQEPTVEKLA
PVESKETSEVQQAEIIEQKDVPVPETSAPTVEPTVEKLKPVESKETSEVQQVEIIEQKDV
PVPETSAPTVEPTVEKLAPVESKETSEVQQAEIIEQKDVPVPETSAPTVEPTVEKLKPVE
SKETSEVQQVEIIEQKDVPVPETSAPTVEPTVEKLAPVESKETSEVQQAEIIEQKDVPVP
ETSAPTVEPTVEKLKPVESKETSEVQQVEIIEQKDVPVPETSAPTVEPTVEKHAPVESKE
TSEVQPAEIVEQKVVPVPETSAPTVEPTVEKLAPVESKETPEVQPAEILEQKDVTCEEEI
KELLTEVEVELFFSKAEVFSGLELDLLMECSEYVTTSIQKGSTAAPAQEPTVEKLAPVES
KETSEVEPAEIVEQKDVPVPETSAPTVEPTVEKLKSVESKETSEVQQAEIIEQKDVPVPE
TSAPTVEPTVEKLAPVDSKETSEVEPAEIVEQKDVTCEEEIKELLTEVEVELLFSQAEVF
SGLELDLLMECSEYVTTSIQKGSTAAPAQEPTVEKLAPVESKETSEVEPAEIVEQKDVPV
PETSAPTVEPTVEKLKSVESKETSEVQQAEIIEQKDVPVPETSAPTVEPTVEKHAPVESK
ETSEVQPAEIVEQKVVPVPETSAPTVEPTVEKLAPVESKETSEVEPAEIVEQKDVPVPET
SAPTVEPTVEKLAPVESKETSEVEPAEIVEQKDVPVPETSAPTVEPTIEKLAPVESKETS
EVEPAEIVEQKDVSVPETSAPTVEPTIEKLAPVESKETSEVEPAEIVEQKDVSVPETSAP
TVEPTVEKLAPVESKETSEVEPAEIVEQKDVPVPETSAPTVEPTVEKLAPVESKETSEVQ
PAEIVEHKDVQVPETSSPTVEPTVEKLAPVESKETSEVEPAEIVEQKDVPVPETSAPTVE
PTVEKLAPVESKETSEVEPAEIVEQKDVPVPETSAPTVEPTVEKLAPVESKETSEVQPAE
IVEQKDVSVPETSAPTVEPTVEKLAPVESKETSEVQPAEIVEQKDVPVPETSAPTVEPTV
EKLAPVESKETSEVQPAEIVEHKDVQVPETSSPTVEPTVEKLAPVESKETSEVEPAEIVE
QKDVPVPETSAPTVEPTVEKLAPVESKETSEVQPAEIVEHKDVQVPETSAPTVEPTIEKL
APVESKETSEVEPAEIVEQKDVSVPETSAPTVEPTIEKLAPVESKETSEVQPAEIVEHKD
VQVPETSSPTVEPTVEKLAPVESKETSEVQPAEIVEQKDVTCEEEIKELLTEVEVELFFS
QAEVFSGLELDLLMECSEYVTTSIQKGSTAAPAHEPTVEKLAPVESKETSEVEPAEIVEQ
KDVPVPETSAPTVEPTVEKLAPVESKETSEVEPAEIVEQKDLPVPETSAPTVEPTVEKLA
PVESKKTSEVEPAEIVEQKDVPVPETSAPTVEPTVEKLAPVESKETSEVEPAEIVEQKDV
PVPETSAPTVEPTVEKLAPVESKETSEVEPAEIVEQKDVPVPETSAPTVEPTIEKLAPVE
SKETSEVEPAEIVEQKDVSVPETSAPTVEPTIEKLAPVESKETSEVEPAEIVEQKDVSVP
ETSAPTVEPTVEKLAPVESKETSEVEPAEIVEQKDVPVPETSAPTVEPTVEKLAPVESKE
TSEVQPAEIVEHKDVQVPETSSPTVEPTVEKLAPVESKETSEVEPAEIVEQKDVPVPETS
APTVEPTVEKLAPVESKETSEVEPAEIVEQKDVPVPETSAPTVEPTVEKLAPVESKETSE
VQPAEIVEHKDVQVPETTATTFEPTKEKLAPVDSKETSEVQTAEIVEQKDVPVPETSATT
VEPTKEKLAPGESKETSEVQQAAIVEQKDVAVPETSATTVEPTKEKLAPVESKETSEIQT
AEIVEQKDVPVPETSTSYVEPTKEKLAPGESKETSEVQQAAIVEQKDVPVPETSATTVEP
TKEKLAPVESKETSEIQQAAVVEQKDVPVPETSATTVEPTKEKLAPVESKETSEVQQAAI
VEQKDVPVPEANAPTFEPTVEKLAPVESKETSEVQQAAIVEQKDVPVPEANAPTVEPTVE
KLAPVESKETSVESKETQADAKLKKEKDDKHKQEADAKLQKENDDKLKQEADAKLKKEND

Modification type: Engineered
Fragment
PDB:  
Structural/functional type: Function arises via a molten globule to order transition
Functional classes: Unknown
Functional subclasses: Unknown
Detection methods:
  1. Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 7; KCl 150 mM; K-phosphate 10 mM; TFE (0%, 20%, 40%, 80% v/v))

  2. Circular dichroism (CD) spectroscopy, far-UV (275 K; pH: 7; KCl 150 mM; K-phosphate 10 mM; Temp range (275, 298, 323, 348K))

  3. Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 7; KCl 150 mM; K-phosphate 10 mM; Urea (0, 2, 5 M))

  4. Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 7; KCl (with or without) 150 mM; K-phosphate 10 mM; NaCl 4 M)

References:
  1. Forbes JG, Flaherty DB, Ma K, Qadota H, Benian GM, Wang K. "Extensive and modular intrinsically disordered segments in C. elegans TTN-1 and implications in filament binding, elasticity and oblique striation." J Mol Biol. . PubMed: 20346955

Comments:
Forbes, et al., speculate function may include acting as a structural-mechanical "force sensor."


Experiments performed on synthesized fragment PEVT39: (Ac-VPETSAPSVEPTVEKLAPVESKETSEVQQAEIVEQKDVP-NH2) 39-mer and synthesized fragment CEEEI (Ac-CEEEIKELLTEVEVELFFSQAEVFSGLELDLLMECSEYVTTSIQKGSTAAP-NH2) 51-mer. The native CEEEI inserts are contained within the PEVT peptide.




Region 3
Type:Disordered - Molten Globule
Name:BLUE
Location:7013 - 8512
Length:1500
Region sequence:

LKQEADAKLKKENDDKLKQEADAKLKKENDDKLKQEADAKLKKENDDKLKQEAAAKLKKE
NDDKLKQEADAKLKKENDDKLKQEADAKLQKENDDKLKQEADAKLQKENDDKLKQEADAK
LQKENDDKLKQEADAKLQKENDDKLKQEADAKLQKENDDKLKQEADAKLKKENDDKLKQE
ADAKLKKEKHDKLKQEADAKLQKENDDKLKQEADAKLQKENDDKLKQEADAKLQKEKDDK
LKQEADAKLKKEKDDKLKQDADAKLQKEKDDKLKQEADAKLKKEKDDKLKHEADAKLQKE
KDDKLKQEADAKLKKEKDDRLKKDADAKLQKEKDDKLKQEADAKLKKEKDDKLKHEADAK
LQKEKDDKLKQEADAKLKKEKDDKLKQEADAKLQKEKDDKLKQEADAKLKKEKDDKLKQE
ADAKLQKEKDDKLKQEADAKLKKEKDDKLKQEADAKLQKEKDDKLKQEADAKLKKEKDDK
LKQEADAKLKKEKDDKLKQDADAKLQKEKDDKLKQEADAKLKKEKDDKLKHEADAKLKKE
KDDKLKQEADAKLKKEKDDKLKQDADAKLKKEKDDKLKHEADAKLQKEKDDNFKQEANAK
LQKEKDDKLKQEKDDNFKQEANAKLQKEKDDKLKQEKDDKLKQEADAKLKKEKDDKLKQE
ADAKLKKEKDDKLKQEADAKLKKDKDDKLKQEADAKLKKEKDDKLKQEADAKLKKDKDDK
LKQEADAKLKKDKDDKLKQEADAKLKKEKDDKLKQEKNDKLKQEADAKLKKEKDDKLKQE
ADAKLKKEKDDKLKQETDAKLKKDKDDKLKQEADAKLKKDKDDKLKQEADAKLKKDKDDK
LKQEADGKLKKEKDNKLKQEADGKLKKEKDNKLKQEADAKLKKEKDDKLKQEADAKLKKE
KDDKLKQEADAKLKKDKDDKLKQEADAKLKKEKDDKLKQEADAKLKKDKDDKLKQEANAK
LQKEKDDKLKQEADAKLQKEKDDKLKQEADAKLKKEKDDKLKQEADAKLQKEKDDKLKQE
ADAKLKKEKDDKLKQEADAKLQKEKDDNFKQEANAKLQKEKDDKLKQEKDDKLKQEADAK
LKKEKDDKLKQEADAKLKKDKDDKLKQEADAKLKKEKDDKLKQEADAKLKKEKDDKLKQE
ADAKLKKDKDDKLKQEADAKLKKDKDDKLKQEADAKLKKEKDDKLKQETDAKLKKDKDDK
LKQEADAKLKKEKDDKLKQEADAKLKKEKDDKLKQEADAKLKKEKDDKLKQEADAKLKKD
KDDKLKQEADAKLKKDKDDKLKQEADGKLKKEKDNKLKQEADGKLKKEKDNKLKQEADAK
LKKEKDDKLKQEADAKLKKDKDDKLKQEADAKLKKEKDDKLKQEADAKLKKEKDDKLKQE
ADAKLKKDKDDKLKQEADAKLKKDKDDKLKQEADAKLKKEKDDKLKQEADAKLKKDKDDK
LKQEADAKLKKDKDDKLKQEADAKLKKEKGDKLKLEDQTNQSRIFEETSIEVTSLLKCKQ

Modification type: Engineered
Fragment
PDB:  
Structural/functional type: Function arises via a molten globule to order transition
Functional classes: Unknown
Functional subclasses: Unknown
Detection methods:
  1. Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 7; KCl 150 mM; K-phosphate 10 mM; TFE (0%, 20%, 40%, 80% v/v))

  2. Circular dichroism (CD) spectroscopy, far-UV (275 K; pH: 7; KCl 150 mM; K-phosphate 10 mM; Temp range (275, 298, 323, 348K))

  3. Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 7; KCl 150 mM; K-phosphate 10 mM; Urea (0, 2, 5 M))

  4. Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 7; KCl 150 mM; K-phosphate 10 mM; NaCl 4 M)

References:
  1. Forbes JG, Flaherty DB, Ma K, Qadota H, Benian GM, Wang K. "Extensive and modular intrinsically disordered segments in C. elegans TTN-1 and implications in filament binding, elasticity and oblique striation." J Mol Biol. . PubMed: 20346955

Comments:
Forbes, et al., speculate function may include acting as both a structural-mechanical "force sensor" and, due to its high temperature sensitivity, as a "thermal sensor." Side-to-side oligomerization may stabilise the A-band during the process of growth.


Experiments were performed on synthesized fragment BLUE32: (Ac-LKQEADAKLKKENDDKLKQEADAKLKKENDDK-NH2) 32-mer




Region 4
Type:Disordered - Molten Globule
Name:DispRep
Location:9326 - 9355
Length:30
Region sequence:

ETVDEKPKKKVLKKKTEKSDSTISETSETS

Modification type: Engineered
Fragment
PDB:  
Structural/functional type: Function arises via a molten globule to order transition
Functional classes: Unknown
Functional subclasses: Unknown
Detection methods:
 
References:
  1. Forbes JG, Flaherty DB, Ma K, Qadota H, Benian GM, Wang K. "Extensive and modular intrinsically disordered segments in C. elegans TTN-1 and implications in filament binding, elasticity and oblique striation." J Mol Biol. . PubMed: 20346955

Comments:
Forbes, et al., speculate function may include acting as a structural-mechanical "force sensor."


Experiments were performed on synthesized fragment DispRep: (Ac-ETVDEKPKKKVLKKKTEKSDSSISQKSETS-NH2) 30-mer. TNN-1 contains several regions of the 'dispersed repetitions' peptide DispRep beginning at a.a. 9326, 9777 and 12096.



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