Annotations for this protein have been verified by the authors of the corresponding papers


DP00694: RING1 and YY1-binding proteinFASTA viewXML view

General information
DisProt:DP00694
Name:RING1 and YY1-binding protein
Synonym(s):RYBP_HUMAN
Death effector domain-associated factor
YY1 and E4TF1-associated factor 1
Apoptin-associating protein 1
APAP-1
DED-associated factor
First appeared in release:Release 5.4 (10/14/2010)
UniProt:Q8N488
UniGene: 
SwissProt: RYBP_HUMAN
TrEMBL:  
NCBI (GI): 112363092
Source organism:Homo sapiens (Human)
Sequence length:228
Percent disordered:100%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MTMGDKKSPT RPKRQAKPAA DEGFWDCSVC TFRNSAEAFK CSICDVRKGT STRKPRINSQ - 60
LVAQQVAQQY ATPPPPKKEK KEKVEKQDKE KPEKDKEISP SVTKKNTNKK TKPKSDILKD - 120
PPSEANSIQS ANATTKTSET NHTSRPRLKN VDRSTAQQLA VTVGNVTVII TDFKEKTRSS - 180
STSSSTVTSS AGSEQQNQSS SGSESTDKGS SRSSTPKGDM SAVNDESF



Functional narrative    

Function: Appears to be involved in cancer, apoptosis and at different stages during developmenet of several organs. Seems to be involved in DAN binding. Seems to be oligomeric. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. In tumor cell lines, may induce apoptosis.
SUBUNIT: Interacts with CBX2, YAF2, IFT57, RING1 and RNF2 (By similarity). Interacts with apoptin, DEDD, FADD, CASP8, CASP10, YY1 and E4TF1B. Together with E4TF1B and YY1, it forms a ternary complex, probably being the bridge factor between these two transcription factors. Component of repressive BCOR complex containing Polycomb group subcomplex at least composed of BCOR, PCGF1, RING1 and RNF2/RING2.


Subcellular Location: Nucleus. Cytoplasm. Note=Primarily found in the nucleus.
TISSUE SPECIFICITY: Widely expressed with highest levels in lymphoid tissues and placenta.
SIMILARITY: Contains 1 RanBP2-type zinc finger. Sequence=AAK63197.1; Type=Erroneous initiation; Sequence=AAO73587.1; Type=Erroneous initiation; Sequence=BAA89486.1; Type=Erroneous initiation;
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Region 1: 1-228

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:1 - 228
Length:228
Region sequence:

MTMGDKKSPTRPKRQAKPAADEGFWDCSVCTFRNSAEAFKCSICDVRKGTSTRKPRINSQ
LVAQQVAQQYATPPPPKKEKKEKVEKQDKEKPEKDKEISPSVTKKNTNKKTKPKSDILKD
PPSEANSIQSANATTKTSETNHTSRPRLKNVDRSTAQQLAVTVGNVTVIITDFKEKTRSS
STSSSTVTSSAGSEQQNQSSSGSESTDKGSSRSSTPKGDMSAVNDESF

Modification type:  
PDB:  
Structural/functional type: Function arises via a disorder to order transition
Functional classes: Molecular recognition effectors
Functional subclasses: Protein-DNA binding
Protein-protein binding
Detection methods:
 
References:
  1. Neira JL, Román-Trufero M, Contreras LM, Prieto J, Singh G, Barrera FN, Renart ML, Vidal M. "The transcriptional repressor RYBP is a natively unfolded protein which folds upon binding to DNA." Biochemistry. 2009; 48(6): 1348-60. PubMed: 19170609
Comments:
 



References

  1. Neira JL, Román-Trufero M, Contreras LM, Prieto J, Singh G, Barrera FN, Renart ML, Vidal M. "The transcriptional repressor RYBP is a natively unfolded protein which folds upon binding to DNA." Biochemistry. 2009; 48(6): 1348-60. PubMed: 19170609



Comments


AV (7-29-2010) PMID:19170609


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