| General information | | DisProt: | DP00696 | | Name: | C-C motif chemokine 26 | | Synonym(s): | CCL26_HUMAN
Small-inducible cytokine A26
Eotaxin-3
Macrophage inflammatory protein 4-alpha
Thymic stroma chemokine-1
CC chemokine IMAC
| | First appeared in release: | Release 5.2 (08/07/2010) | | UniProt: | Q9Y258 | | UniGene: | Hs.131342 | | SwissProt: | CCL26_HUMAN | | TrEMBL: | | | NCBI (GI): | 5174671 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 94 | | Percent disordered: | 10% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MMGLSLASAV LLASLLSLHL GTATRGSDIS KTCCFQYSHK PLPWTWVRSY EFTSNSCSQR - 60
AVIFTTKRGK KVCTHPRKKW VQKYISLLKT PKQL
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| Functional narrative |
Chemotactic for eosinophils and basophils. Binds to CCR3.
Ubiquitously expressed at low levels in various tissues including heart and ovary.
Belongs to the intercrine beta (chemokine CC) family.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | N-terminal | | Location: | 1 - 9 | | Length: | 9 | | Region sequence: |
MMGLSLASA | | Modification type: | Monomeric
Native
| | PDB: | 1G2S:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | Substrate/ligand binding
| Detection methods:
- Nuclear magnetic resonance (NMR) (303 K; pH: 5.5; deuterated sodium acetate; NaN3 0.02 %; protein (sample) 2 mM; Varian UnityINOVA (spectrometer) 500 MHz)
| References:
- Ye J, Mayer KL, Mayer MR, Stone MJ. "NMR solution structure and backbone dynamics of the CC chemokine eotaxin-3." Biochemistry. 2001; 40(26): 7820-7831. PubMed: 11425309
| Comments:
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