DP00730: OncomodulinFASTA viewXML view

General information
DisProt:DP00730
Name:Oncomodulin
Synonym(s):ONCO_RAT
Parvalbumin beta
OM
First appeared in release:Release 6.00 (07/01/2012)
UniProt:P02631
UniGene: 
SwissProt: ONCO_RAT
TrEMBL:  
NCBI (GI):  
Source organism:Rattus norvegicus (Rat)
Sequence length:109
Percent disordered:61%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MSITDILSAE DIAAALQECQ DPDTFEPQKF FQTSGLSKMS ASQVKDIFRF IDNDQSGYLD - 60
GDELKYFLQK FQSDARELTE SETKSLMDAA DNDGDGKIGA DEFQEMVHS



Functional narrative    

Function: Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions.
TISSUE SPECIFICITY: Found in tumor tissues and not detected in normal tissues.
SIMILARITY: Belongs to the parvalbumin family.
SIMILARITY: Contains 2 EF-hand domains.
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Region 1: 1-8 Region 2: 60-62 Region 4: 42-71 Region 5: 82-109 Region 3: 108-109

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name:N-terminal
Location:1 - 8
Length:8
Region sequence:

MSITDILS

Modification type: Complex
Engineered
PDB: 1RRO:A
Structural/functional type: Function arises from the disordered state
Functional classes: Molecular recognition effectors
Functional subclasses: Intraprotein interaction
Substrate/ligand binding
Detection methods:
  1. X-ray crystallography (Ca2+; Oncomodulin protein)
References:
  1. Ahmed FR, Rose DR, Evans SV, Pippy ME, To R. "Refinement of recombinant oncomodulin at 1.30 A resolution." J. Mol. Biol.. 1993; 230(4): 1216-24. PubMed: 8487302
Comments:
 



Region 2
Type:Disordered
Name:CD loop
Location:60 - 62
Length:3
Region sequence:

DGD

Modification type: Complex
Engineered
PDB: 1RRO:A
Structural/functional type: Function arises from the disordered state
Functional classes: Molecular recognition effectors
Functional subclasses: Intraprotein interaction
Substrate/ligand binding
Detection methods:
  1. X-ray crystallography (Ca2+; Oncomodulin protein)
References:
  1. Ahmed FR, Rose DR, Evans SV, Pippy ME, To R. "Refinement of recombinant oncomodulin at 1.30 A resolution." J. Mol. Biol.. 1993; 230(4): 1216-24. PubMed: 8487302
Comments:
 



Region 3
Type:Disordered
Name:C-terminal
Location:108 - 109
Length:2
Region sequence:

HS

Modification type: Complex
Engineered
PDB: 1RRO:A
Structural/functional type: Relationship to function unknown
Functional classes: Molecular recognition effectors
Functional subclasses: Intraprotein interaction
Substrate/ligand binding
Detection methods:
  1. X-ray crystallography (Ca2+; Oncomodulin protein)
References:
  1. Ahmed FR, Rose DR, Evans SV, Pippy ME, To R. "Refinement of recombinant oncomodulin at 1.30 A resolution." J. Mol. Biol.. 1993; 230(4): 1216-24. PubMed: 8487302
Comments:
 



Region 4
Type:Disordered
Name:CD region
Location:42 - 71
Length:30
Region sequence:

SQVKDIFRFIDNDQSGYLDGDELKYFLQKF

Modification type: Native
PDB: 2NLN:A
Structural/functional type: Function arises via a disorder to order transition
Functional classes: Molecular recognition effectors
Functional subclasses: Intraprotein interaction
Substrate/ligand binding
Detection methods:
  1. Nuclear magnetic resonance (NMR) (293 K; pH: 6; 90% H2O, 10% D2O (solvent system); Mes 0.01 M; NaCl 0.15 M; Oncomodulin protein (calcium-free) 4 mM)
References:
  1. Henzl MT, Tanner JJ. "Solution structure of Ca2+-free rat beta-parvalbumin (oncomodulin)." Protein Sci.. 2007; 16(9): 1914-26. PubMed: 17766386
Comments:
Henzl et al (2007) comment that "Ca2+ removal provokes substantial reorganization of the hydrophobic core."




Region 5
Type:Disordered
Name:CD region
Location:82 - 109
Length:28
Region sequence:

ETKSLMDAADNDGDGKIGADEFQEMVHS

Modification type: Native
PDB: 2NLN:A
Structural/functional type: Function arises via a disorder to order transition
Functional classes: Molecular recognition effectors
Functional subclasses: Intraprotein interaction
Substrate/ligand binding
Detection methods:
  1. Nuclear magnetic resonance (NMR) (293 K; pH: 6; 90% H2O, 10% D2O (solvent system); Mes 0.01 M; NaCl 0.15 M; Oncomodulin protein (calcium-free) 4 mM)
References:
  1. Henzl MT, Tanner JJ. "Solution structure of Ca2+-free rat beta-parvalbumin (oncomodulin)." Protein Sci.. 2007; 16(9): 1914-26. PubMed: 17766386
Comments:
Henzl et al (2007) comment that "Ca2+ removal provokes substantial reorganization of the hydrophobic core."




Comments


AV sent 10/1/2012 (PMID 17766386)


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